Search results for "mem"
showing 10 items of 7971 documents
Errores conceptuales en el estudio del equilibrio químico : nuevas aportaciones relacionadas con la incorrecta aplicación del principio de Le Chateli…
2021
Resumen basado en el de la publicación Resumen en inglés La utilidad limitada del principio de Le Chatelier y su formulación vaga y ambigua pueden ser algunas de las fuentes de conceptos erróneos en el equilibrio químico. Para diagnosticar conceptos erróneos, se administró una prueba escrita a 170 estudiantes universitarios de primer año. Las respuestas revelaron que los errores surgieron en términos generales: a) la mala aplicación y la incomprensión del Principio de Le Chatelier; b) utilización de recordatorios de memorización y procedimientos algorítmicos; c) control incorrecto de las variables involucradas y uso limitado de la ley de equilibrio químico; d) falta de dominio de los princi…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Spigolando fra i racconti di Raffaele Poidomani
2014
Voices from the past: memory and desire in Marina Warner’s radio play Brigit’s Cell
2020
This article examines Marina Warner’s radio play Birgitta’s Cell (BBC Radio 4), later published as Brigit’s Cell (2010) focusing on the themes of memory and desire. By drawing on Jan Assman’s theories on collective memory, the article shows how the two time levels Warner builds in the radio drama succeed in creating a fresh connection between women in the past and in the present as well as between individual and collective experience. The analysis of Warner’s work focuses on the dramatization of the story, taking into account the results offered by the use of the spoken word, fragments of dialogues, interior monologues, silences, enhanced, by its initial destination for the radio.
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
Encuentro de saberes: Huellas de memoria pluriversa y descolonización de la Universidad contemporánea
2018
This paper studies the Encounter of Knowledge as a project that, by welcoming mestres and mestras of ancestral knowledge into universities, contributes to decolonize higher education, broadening its field of memory. Based on a systematization exercise, we established a theoretical dialogue with Bajtin and Bejamin. Based on the participation of four mestres -Lucely Pío, raicera del Cerrado, Mãe Lu and Tata Mutá Imé, religious leaders of Candomblé and the political leader and shaman Álvaro Tukano of the Tukano nation- we show how the project promotes in the contemporary Brazilian university a space of mnemic pluriversity, capable of activating diverse narrative planes (biographical, political…
Effect of cholesterol-lowering treatment with a 585 on plasma membrane function and liver electron microscope appearence in rats.
1990
Biological and Proteomic Characterization of the Anti-Cancer Potency of Aqueous Extracts from Cell-Free Coelomic Fluid of Arbacia lixula Sea Urchin i…
2022
Echinoderms are an acknowledged source of bioactive compounds exerting various beneficial effects on human health. Here, we examined the potential in vitro anti-hepatocarcinoma effects of aqueous extracts of the cell-free coelomic fluid obtained from the sea urchin Arbacia lixula using the HepG2 cell line as a model system. This was accomplished by employing a combination of colorimetric, microscopic and flow cytometric assays to determine cell viability, cell cycle distribution, the possible onset of apoptosis, the accumulation rate of acidic vesicular organelles, mitochondrial polarization, cell redox state and cell locomotory ability. The obtained data show that exposed HepG2 cells under…
Forgetful Audiences in Julius Caesar
2012
On note dans Jules César une récurrence d'épisodes où la mémoire du spectateur défaille, quand des personnages oublient une scène à laquelle ils viennent d'assister ou la retiennent de façon approximative. Cet article s'intéresse aux manifestations dramatiques et méta-théâtrales de ce phénomène, et avance que ces scènes d'oubli sont pour l'auteur le moyen de démontrer le caractère fuyant de la mémoire empirique et de proposer que le théâtre, plutôt que la salle de classe, constitue un terrain propice à l'exercice de cette mémoire. Julius Caesar exhibits a pattern of audience forgetfulness, when characters forget scenes they have just witnessed, or when they remember them imperfectly. This p…
Mecanismos moleculares del deterioro cognitivo en encefalopatía hepática mínima. Papel de la neuroinflamación en la alteración de la neurotransmisión
2018
La encefalopatía hepática (EH) es un síndrome neuropsiquiátrico que afecta a un gran número de pacientes con diversas enfermedades hepáticas, especialmente cirrosis, como consecuencia de la acumulación de deshechos metabólicos mal detoxificados, sobre todo amonio. En su forma más leve, la EH mínima cursa con déficit cognitivo y motor leve que es reproducido por las ratas hiperamonémicas, uno de los modelos empleados para su estudio. Además, estas ratas presentan neuroinflamación, otro de los factores desencadenantes de este síndrome. Se ha visto que las ratas hiperamonémicas presentan alteraciones en la expresión en membrana de receptores de glutamato en el hipocampo, lo cual se ha relacion…