Search results for "methods"
showing 10 items of 4526 documents
Quantification of the heterogeneity of prognostic cellular biomarkers in ewing sarcoma using automated image and random survival forest analysis
2014
Driven by genomic somatic variation, tumour tissues are typically heterogeneous, yet unbiased quantitative methods are rarely used to analyse heterogeneity at the protein level. Motivated by this problem, we developed automated image segmentation of images of multiple biomarkers in Ewing sarcoma to generate distributions of biomarkers between and within tumour cells. We further integrate high dimensional data with patient clinical outcomes utilising random survival forest (RSF) machine learning. Using material from cohorts of genetically diagnosed Ewing sarcoma with EWSR1 chromosomal translocations, confocal images of tissue microarrays were segmented with level sets and watershed algorithm…
Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum
2021
Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximu…
On the Construction of Optimum Categories in Biomedical Data Recognition Problems
1979
The recognition of patterns within sets of biomedical data involves the following problems: a) Proper recording of the data to be used b) Extraction of suitable features c) Choice of categories or classes which are relevant to the medical decision task d) Estimation of the underlying distributions in the case of using parametric methods e) Choice of an adequate classification rule Whereas a lot of theories and procedures exists for most of these steps — particularly in the field of computer-aided differential diagnosis of electrocardiograms (ECG) (see [6]) — there has been only rare considerations on the problems of definition of appropriate categories.
Development of Peat Processing Methods for Production of Innovative Products
2020
Synthesis or humification of humic substances (HSs) is the second widely applied organic compound transformation process after photosynthesis. Peat decomposition process results in a production of a HSs which has a high demand in agriculture, forestry, and gardening areas. Addition of the KOH is good option for environmental protection and K+ belongs to the nitrogen, potassium and phosphorous (NKP) mineral component. A homogenization process in a customize for commerce, where peat treatment technology was improved with the help of the cavitation effect. This effect was provided with the help of the high-speed mixer-disperser (HSMD) developed at Riga Technical University. Mechanical cavitati…
Filmu fragmenti angļu valodas gramatikas induktīvai apguvei 12. klasē
2016
Skolēnu vajadzības un vēlmes attiecībā uz angļu valodas mācīšanos laika gaitā ir mainījušās, tādēļ, lai nodrošinātu skolēnu mācīšanās vajadzību un vēlmju ievērošanu, skolotājiem ir jābūt informētiem par jaunākajām mācību metodēm un pieejām angļu valodas mācīšanai. Mūsdienās skolēniem nesagādā grūtības komunikācija angļu valodā un viņi ir prasmīgi valodas lietotāji, pateicoties interneta videi, kurā skolēni pavada daļu brīvā laika. Skolotāju loma ir nodrošināt skolēnus ar pareizas valodas un gramatikas lietošanas priekšnosacījumiem, piedāvājot motivējošas un interesantas valodas mācīšanās metodes un instrumentus. Ņemot vērā iepriekšminēto, diplomdarba autore veica pētījumu, lai noskaidrotu k…
Mācību metožu izvēle matemātikā 10. klasei, balstoties H.Gārdnera daudzveidīgo inteliģenču teorijā
2014
Bakalaura darba tēma ir „Mācību metožu izvēle matemātikā 10. klasei, balstoties H. Gārdnera daudzveidīgo inteliģenču teorijā”. Teorētiskajā daļā apkopotas mācību metodes atbilstoši 7 inteliģencēm, bet pētnieciskajā daļā tās ir iekļautas mācību procesā ar mērķi pārbaudīt to labvēlīgo ietekmi uz mācību sasniegumu uzlabošanos. Darbs sastāv no 3 nodaļām – teorētiskā apskata, metodoloģijas un pētījuma daļas. Tajā iekļautas 9 tabulas, 12 attēli, 17 literatūras avoti.
Usual Care and Informed Consent in Clinical Trials of Oxygen Management in Extremely Premature Infants
2016
Objective The adequacy of informed consent in the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) has been questioned. SUPPORT investigators and publishing editors, heads of government study funding agencies, and many ethicists have argued that informed consent was adequate because the two oxygen saturation target ranges studied fell within a range commonly recommended in guidelines. We sought to determine whether each oxygen target as studied in SUPPORT and four similar randomized controlled trials (RCTs) was consistent with usual care. Design/Participants/Setting PubMed, EMBASE, Web of Science, and Scopus were searched for English articles back to 1990 providi…
Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
2011
Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 me…
Incidence of neuronal ceroid-lipofuscinoses in West Germany: Variation of a method for studying autosomal recessive disorders
1992
The incidence of neuronal ceroid-lipofuscinoses (NCL) in West Germany was determined using a novel method which is applicable to other autosomal recessively inherited diseases. Questionnaires were sent to all pediatric departments (answer rate 189/276, 68%), schools for the blind (39/46, 85%), and neuropathological institutes (15/22, 68%). Diagnoses were accepted only when based on firm clinical and/or electron microscopic criteria; 207 such identified patients were sorted according to year of birth. Plotting the cumulative number of new cases per year against the year of birth resulted in a slightly S-shaped curve. Before the year 1962, the curve is relatively flat, probably due to ineffic…
Detection of cancer through exhaled breath: a systematic review
2015
// Agne Krilaviciute 1 , Jonathan Alexander Heiss 1 , Marcis Leja 2 , Juozas Kupcinskas 3 , Hossam Haick 4 and Hermann Brenner 1,5,6 1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany 2 Faculty of Medicine, University of Latvia, Digestive Diseases Center GASTRO, and Riga East University Hospital, Riga, Latvia 3 Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania 4 Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology, Haifa, Israel 5 Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany…