Search results for "miR"
showing 10 items of 1117 documents
Analysis of MSCs' secretome and EVs cargo: Evaluation of functions and applications
2022
Mesenchymal stem cells (MSCs) can exert different functions and can be used in several medical fields. In the last years, MSC properties have been attributed to their secreted factors such as soluble proteins, cytokines and growth factors. Moreover, a key role is played by the extracellular vesicles (EVs) which lead a heterogeneous cargo of proteins, lipids and small and long non-coding RNAs that interfere with the pathways of the recipient cells. Due to the safeness and easiness in obtaining the secretome, its use is becoming a turning point for the application in physiological and pathological fields. This review summarizes the most recent studies on the use of MSCs secretome, focusing on…
MiR-29b-1 expression impaired Cancer Stem-Like properties of human osteosarcoma 3AB-OS cells in vitro.
2013
Osteosarcoma (OS) is the most common type of bone cancer, with a peak incidence in the early childhood. Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. Although microRNAs are frequently dysregulated in human cancers, if they influence OS malignancy and whether or not targeting CSC-associated microRNAs inhibit OS progression remain unclear. Recently (1), we described a predictive network for two downregulated miRNA family (let-7/98 and miR-29a,b,c) and their upregulated anticorrelated mRNAs. Here, we investigated in vitro the role of miR-29b-1 in regulating cell proliferation, clonogenic growth and che…
MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells
2022
Abstract Chronic lymphocytic leukemia (CLL) cells express the interleukin-23 receptor (IL-23R) chain, but the expression of the complementary IL-12Rβ1 chain requires cell stimulation via surface CD40 molecules (and not via the B-cell receptor [BCR]). This stimulation induces the expression of a heterodimeric functional IL-23R complex and the secretion of IL-23, initiating an autocrine loop that drives leukemic cell expansion. Based on the observation in 224 untreated Binet stage A patients that the cases with the lowest miR-146b-5p concentrations had the shortest time to first treatment (TTFT), we hypothesized that miR-146b-5p could negatively regulate IL-12Rβ1 side chain expression and clo…
Mobilisation of plasmid-mediated blaVEB-1 gene cassette into distinct genomic islands of Proteus mirabilis after ceftazidime exposure
2021
ABSTRACT Objectives We sought to integrate a VEB-1-encoding gene cassette into the integron of the MDR region of genomic islands (GIs) harboured by Proteus mirabilis strains after antibiotic exposure. Methods An IncP1 plasmid from Achromobacter xylosoxidans carrying the cassette array dfrA14–blaVEB-1–aadB was introduced by conjugation into five strains of P. mirabilis: PmBRI, PmABB, PmSCO and Pm2CHAMA harbouring Salmonella GI 1 and PmESC harbouring Proteus GI 1. Circular intermediates of the cassettes were amplified by PCR. blaVEB-harbouring P. mirabilis were exposed to increasing concentrations of ceftazidime each day. Presence of blaVEB-1 in the GI was assessed by PCR. The complete MDR re…
A MEMS array-type Mirau interferometer for swept-source OCT imaging with applications in dermatology
2017
In the frame the European project VIAMOS (www.viamos.eu) we developed a microsystem based on Mirau interferometry and applied for optical coherence tomography (OCT) imaging of living tissues. The objective is to benefit from advanced MOEMS technologies, enabling a new generation of miniature and low-cost instruments using the concept of the swept-source OCT (SS-OCT) microsystem based on spectrally tuned Mirau interferometry, into which a doublet of microlens matrices (4×4) and a wafer of movable reference mirrors are included, building the active Mirau interferometer.
Zvaigžņotā Debess: 2010, Vasara (208)
2010
Contents: N.Cimahoviča. Sun’s Researcher in the Far East ; A.Balklavs. A New Hypothesis on Formation of Galaxies ; A.Balklavs. Gravitation and Peculiar Galaxies ; A.Barzdis. First Population Stars and Galaxies ; Z.Alksne, A.Alksnis. Does Giant Planet Orbit Dwarf Star? ; A.Alksnis, Z.Alksne. Epsilon Aurigae Eclipsed by Dark Dust Disk ; M.Ābele, K.Adgere, E.Grabs, L.Osipova, E.Rutkovska, J.Vjaters, V.Veckalns. Latvian Students Take Part in the Project European Student Moon Orbiter ; Announcement on the 3rd International Symposium on Dark-Sky Parks: 6-10 September 2010, Croatia ; J.Jansons. Vladimir Afanasjev – Officer of the Baikonur Cosmodrom in the 1970s ; J.Limansky. The International Year…
Relación breve, y verdadera del prodigioso señal, qve se viò sobre la Ciudad de Gerona à 20 de Octubre, deste año de 1682.
Sign.: A2
Quatrocientos milagros, y muchas alabanças de la Santa Cruz : con vnos tratados de las cosas mas notables desta diuina señal / compuestos por el P.…
1600
Sign.: [calderó}4, 2{calderó}8, A-Z8, Aa-Pp8 Grav. xil. de Crist a la creu en v. port. Errors de paginació. - Caplletres
Libro de la cofradia de la Minerva : en el qual se escriuen mas de doszientos y cinquenta milagros del Santissimo Sacramento del Altar / compuesto po…
1600
Sign.: Ä8, A-Z8, 2A-2Q8 Dos port., la segona en p. 371. - Caplletres
Progettare in Sicilia al tempo del «Miracolo Economico»: il sogno di una moderna socialità nelle documentazioni degli archivi di architettura
2021
A sette anni dalla sua fondazione la Regione Autonoma Siciliana a Statuto Speciale, istituita nel 1946, si andava affermando, nel bene e nel male, come un vero “laboratorio politico e amministrativo”. In ambito architettonico il decennio del «Miracolo Economico» in Sicilia si apre con realizzazioni significative dell’avvenuta maturazione di una cultura del progetto che, dopo le pur apprezzabili permanenze novecentiste e gli entusiasti richiami a modi razionalisti oramai datati, ma assai opportuni in quella fase di ristrettezze dell’immediato dopoguerra, aveva saputo maturare sia una peculiare linea neo funzionalista sia contestualizzate declinazioni delle tendenze “altre” rispetto all’irres…