Search results for "mito"
showing 10 items of 2513 documents
Molecular analysis of genetic diversity of Phytophthora citrophthora using nuclear and mitochondrial markers
Elucidating geological and biological processes underlying the diversification of Sulawesi tarsiers.
2009
Because of their exceptionally long independent evolution, a range diminution of their Eocene relatives, and a remarkable subsequent diversification in Southeast Asia, tarsiers are of particular importance to evolutionary primatologists. Little is known, however, on the processes shaping the radiation of these small enigmatic primates—especially on the Indonesian island of Sulawesi, their center of endemism. Geological reconstructions and progress in applying DNA sequence information to divergence dating now provide us with the tools and background to comprehend tarsier dispersal. Here, we describe effects of plate-tectonic movements, Pleistocene sea level changes, and hybridization on the…
Mitochondrial DNA deletion and male infertility
2009
Abstract The term “male infertility” does not constitute a defined clinical syndrome, but rather, a collection of different conditions exhibiting a variety of aetiologies and varying diagnosis. In men, oligozoospermia, asthenozoospermia, teratozoospermia and azoospermia are the main causes of infertility. The present research is aimed to investigate if mtDNA deletions can cause sperm defects in idiopathic astenozoospermic patients with different sperm motility and sperm concentration. The incidence of deletions in mtDNA (mtDNA) was co-related with diagnostic categorization of male infertility when 6.6kb out of the 16.6kb of the mitochondrial genome was amplified from whole sperm samples, f…
Mitohondriālo slimību diagnostika, izmantojot molekulārās bioloģijas metodes un citoplazmatisko hibrīdu šūnu modeļus
2017
Mitohondriju galvenā funkcija ir enerģijas ražošana šūnā. Traucējumi mitohondriju elpošanas ķēdē var izraisīt plaša spektra patoloģijas. Patogēno mtDNS mutāciju ietekmi uz šūnu fenotipu iespējams pētīt citoplazmatisko hibrīdu šūnu līnijās. Darba mērķis ir analizēt citoplazmatisko hibrīdu šūnu modeļus un noteikt to piemērotību mitohondriālo slimību raksturošanai un diagnostikai. Tika veikta kontroles grupas un pacientu citoplazmatisko hibrīdu šūnu līniju mtDNS fragmentu sekvenēšana, mtDNS kopiju skaita, ATF koncentrācijas un elpošanas ķēdes kompleksu aktivitāšu noteikšana un salīdzināšana, kā arī tika raksturota izveidoto šūnu līniju stabilitāte. Lai apstiprinātu atbilstību donoru trombocītu…
Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle
2020
Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity.
Conseguenze metaboliche dell'ipossia
2011
Riassunto La sopravvivenza in condizioni di ipossia dipende dall’attivazione di processi cellulari complessi, con risposte di adattamento (quali il potenziamento del trasporto di O2 attraverso l’aumento dell’eritropoiesi, l’attivazione dell’angiogenesi e l’aumento della glicolisi anaerobica) e l’inibizione di processi metabolici che richiedono alta disponibilità di O2. Ciò consente di mantenere l’omeostasi energetica anche in condizioni di ridotta disponibilità di O2. Nel modello fisiologico del soggiorno ad alta quota si verificano riduzione di peso e della capacità di lavoro associata a riduzione della massa muscolare, che però sono reversibili al ripristino di condizioni di normossia. Le…
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …
Golema mīts Gustava Mairinka romānā “Golems” un Pītera Akroida romānā “Dens Līno un Laimhausas Golems”
2016
Bakalaura darba nosaukums ir Golema mīts Gustava Mairinka romānā Golems un Pītera Akroida romānā Dens Līno un Laimhausas Golems…. Šis darbs ir veltīts analīzei par Golema mītu Gustava Mairinka romānā “Golems” un P. Akroida romānā “Dens Lino un Laimhausas Golems”. Šis temats ir svarīgs, jo abi autori attēlo problēmas un tēlus, kuri ir svarīgi arī 21.gadsimtā. Abi autori diskutē par cilvēka dabu un tās īpatnībām. Mairinks un Akroids savos darbos izmanto Golema mītu kā prototipu saviem romāniem, taču abos romānos Golema interpretācija ir atšķirīga un nav līdzīga tā oriģinālam. Pētījuma mērķis ir analizēt Golema mītu, tā lomu literatūrā unatklāt būtiskākās īpatnības dažādajās mīta interpretācij…
Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
2010
Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…
La creencia en neuromitos en formación inicial de docentes de educación especial en Ecuador
2021
Se analizan las percepciones que tienen los futuros docentes ecuatorianos sobre neurociencia relacionada con la educación. Se presentó un cuestionario con 10 afirmaciones sobre las cuales debían indicar su nivel de conformidad. Los resultados demuestran una alta creencia en neuromitos, lo cual podría repercutir directamente en su futura práctica educativa.