Search results for "mito"
showing 10 items of 2513 documents
La asimilación de Barba Azul con la figura del tirano en las obras de Perrault y Bartók
2011
De acuerdo con Paul Ricoeur, se puede acceder a toda relación simbólica desde tres diferentes niveles de comprensión; a saber, uno cósmico, uno onírico y uno poético. El estudio de cada uno de ellos aportará una serie de directrices que, puestas en común con las restantes, permitirán la observación de rasgos análogos y sintomáticos en el texto trabajado, lo que posibilitará comprender, más allá de cuanto en la narración resulta explícito, aquello que permanece en la oscuridad del proceso formativo. Aplicaremos estas propuestas sobre el Barba Azul de Perrault para confrontarlas con la obra homónima de Bartók y desvelar, de este modo, las sorprendentes asimilaciones encontradas entre el señor…
Mitochondrial DNA Regionalism and Historical Demography in the Extant Populations of Chirocephalus kerkyrensis (Branchiopoda: Anostraca)
2012
BackgroundMediterranean temporary water bodies are important reservoirs of biodiversity and host a unique assemblage of diapausing aquatic invertebrates. These environments are currently vanishing because of increasing human pressure. Chirocephalus kerkyrensis is a fairy shrimp typical of temporary water bodies in Mediterranean plain forests and has undergone a substantial decline in number of populations in recent years due to habitat loss. We assessed patterns of genetic connectivity and phylogeographic history in the seven extant populations of the species from Albania, Corfu Is. (Greece), Southern and Central Italy.Methodology/principal findingsWe analyzed sequence variation at two mito…
Out of Asia: Mitochondrial DNA Evidence for an Oriental Origin of Tiger Frogs, Genus Hoplobatrachus
2001
Most examples of intercontinental dispersal events after the Miocene contact between Africa and Asia involve mammal lineages. Among amphibians, a number of probably related groups are known from both continents, but their phylogenies are so far largely unresolved. To test the hypothesis of Miocene dispersal against a Mesozoic vicariance scenario in the context of Gondwana fragmentation, we analyzed fragments of the mitochondrial 16S rRNA gene (572 bp) in 40 specimens of 34 species of the anuran family Ranidae. Results corroborated the monophyly of tiger frogs (genus Hoplobatrachus), a genus with representatives in Africa and Asia. The African H. occipitalis was the sister group of the Asian…
High Anti-Lymphoma Activity of Bendamustine/Mitoxantrone/Rituximab (BMR) in Rituximab Pretreated Relapsed or Refractory Indolent Lymphomas. A Multice…
2006
Abstract Purpose: Bendamustine is a new anti-lymphoma agent with promising activity. Based on a preceeding phase I study the current trial explored Bendamustine in combination with Mitoxantrone and Rituximab (BMR) in patients with relapsed or refractory indolent lymphomas. Patients and Methods: Patients with relapsed or refractory symptomatic stage III/IV indolent lymphomas with or without prior treatment with Rituximab were eligible. Therapy consisted of Bendamustine 90 mg/m2 days 1+2, Mitoxantrone 10 mg/m2 day 1, Rituximab 375 mg/m2 day 8. Treatment was repeated on day 29 for a total of 4 cycles. Results: Between 04/03 and 07/04 62 patients were recruited from 24 participating institution…
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
2015
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ?accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. "Regulated cell death" (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to…
Determination of lectin-cell-binding parameters by a new agglutination technique.
1992
We applied a recently described technique which is based on a light transmission/scattering method to determine the association characteristics of the Geodia lectin to sheep erythrocytes. The agglutination assays were performed in a total volume of 3 ml with 5.4 x 10(6) erythrocytes/ml. At a concentration of 360 ng/ml 50% of the lectin molecules were bound to the cells within the first 10 s of incubation. Scatchard analyses revealed an association constant (K(a)) of 0.9 +/- 0.1 x 10(8) M-1 and a number of 3.8 +/- 0.6 x 10(6) lectin binding sites on one erythrocyte. The method was also successfully applied to determine quantitatively the inhibitory potential of sugars competing with cell sur…
Therapeutic implications of targeting antioxidants to mitochondria
2021
Abstract Redox and oxidative balance are mainly regulated by mitochondria, which control the life and death of cells and organisms, and are therefore implicated in multiple pathologies. Mitochondria can be considered key organelles to be used in different therapeutically approaches, and mitochondria-targeted antioxidants have already shown great potential in the treatment of various human diseases. In fact, major progress has been achieved in the development of different molecules targeted to mitochondria. In this chapter, we will discuss the various strategies that have been employed, such as molecules conjugated with lipophilic cations (e.g., triphenylphosphonium) and peptide-based compou…
Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film for wound healing application.
2018
Crosslinked xyloglucan-poly(vinyl alcohol) based hydrogel films are interesting materials for wound healing applications. This work focuses on the hydrolytic degradation and consequent morphological modification of a XG-PVA film and on its interaction with cells, blood, bacteria. Biocompatibility of the film was assessed in vitro by investigating different aspects, such as cell viability, oxidative stress level, mitochondrial dysfunction and specific stress biomarkers. Partial adhesiveness was demonstrated by performing different attaching assays and phalloidin staining. Hemocompatibility of XG-PVA film after interaction with blood was evaluated by using a multi-parametric approach, includi…
Euonymus maackii Rupr. Seed oil as a new potential non-edible feedstock for biodiesel
2019
Abstract In this study, Euonymus maackii Seed oil (EMSO) was exploited and evaluated for the first time as a new non-edible oil feedstock for preparation of biodiesel. The EMSO yield was 41.06 ± 2.68 wt%. The fatty acid compositions of EMSO involved palmitoleic acid (2.01%), palmitic acid (14.5%), stearic acid (3.1%), oleic acid (49.8%), linoleic acid (29.3%), 11-Eicosenoic acid (0.1%) and arachidic acid (0.07%). Microwave-assisted transesterification with methanol provided a high conversion yield in short duration under low temperature. The 2.0 wt% of catalyst amount, 10:1 of methanol/oil molar ratio, 40 min of reaction time and 60 °C of temperature were found to be the optimum process condi…
The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
2021
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the motor system. It is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and paralysis. ALS is incurable and has a bleak prognosis, with median survival of 3–5 years after the initial symptomatology. In ALS, motor neurons gradually degenerate and die. Many features of mitochondrial dysfunction are manifested in neurodegenerative diseases, including ALS. Mitochondria have shown to be an early target in ALS pathophysiology and contribute to disease progression. Disruption of their axonal transport, excessive generation of reactive oxygen species, disruptio…