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RESEARCH PRODUCT
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Lorenzo GalluzziThomas RudelHans-uwe SimonVishva M. DixitErwin F. WagnerMarie-lise GougeonAndreas LinkermannJ M Bravo-san PedroRosario RizzutoCecília M. P. RodriguesGian Maria FimiaHidenori IchijoMathieu J.m. BertrandMathieu J.m. BertrandKodi S. RavichandranFrancis Ka-ming ChanStephen W.g. TaitJochen H. M. PrehnRichard A. LockshinValina L. DawsonAndreas VillungerSharad KumarSharad KumarEmily H. ChengCarlos López-otínTheocharis PanaretakisLucia AltucciGabriel A. RabinovichMichelangelo CampanellaPeter VandenabeelePeter VandenabeeleMarcus E. PeterFrancesco CecconiNoboru MizushimaIlio VitaleFrank MadeoMikhail V. BlagosklonnyZahra ZakeriStuart A. AaronsonGabriel NúñezEric H. BaehreckeNektarios TavernarakisNektarios TavernarakisGyorgy SzabadkaiGyorgy SzabadkaiEleonora CandiBrent R. StockwellBrent R. StockwellDale E. BredesenDale E. BredesenSeamus J. MartinThomas KaufmannSonia MelinoDieter AdamJohn M. AbramsKatiuscia BianchiKatiuscia BianchiYufang ShiEmad S. AlnemriKlas BlomgrenPascal MeierCatherine BrennerCatherine BrennerMichael O. HengartnerPhilipp J. JostJ M HardwickEileen WhiteT Vanden BergheT Vanden BergheN. Di DanieleNicolas G. BazanH. L. TangMauro PiacentiniV De LaurenziBeth LevineBeth LevineMargherita Annicchiarico-petruzzelliJosef M. PenningerWalter MalorniTed M. DawsonCarmen GarridoDavid W. AndrewsDouglas R. GreenGyörgy HajnóczkyJerry E. ChipukWafik S. El-deiryChristoph BornerStuart A. LiptonJohn A. CidlowskiKlaus-michael DebatinJunying YuanJan Paul MedemaBertrand JosephAaron CiechanoverUte M. MollHinrich GronemeyerPaolo PintonGerry MelinoGerry MelinoDaniel J. KlionskySimone FuldaJohn J. LemastersCristina Muñoz-pinedoHamsa PuthalakathNavdeep S. ChandelR De MariaJean-christophe MarineRichard A. FlavellBrian David DynlachtW. G. WoodHenning WalczakDavid C. RubinszteinGuido KroemerOliver KeppRichard A. KnightRichard A. KnightAndrew OberstEnrico LugliJ-c MartinouBoris ZhivotovskyBoris ZhivotovskyYoshihide Tsujimotosubject
Biochemical Manifestations of Cell DeathISCHEMIA-REPERFUSION INJURYApoptosisReviewTransduction (genetics)0302 clinical medicineCASPASE INHIBITION SWITCHESAnimals; Humans; Terminology as Topic; Apoptosis; Signal Transduction610 Medicine & healthCaspaseTUMOR-NECROSIS-FACTOR0303 health sciencesSettore BIO/17biologySettore BIO/11NeurodegenerationSettore BIO/13APOPTOSIS3. Good healthMedicina Básicacell death030220 oncology & carcinogenesiscell death; Morphologic Aspects of Cell Death; Biochemical Manifestations of Cell DeathSignal transductionDOMAIN-LIKE PROTEINIntracellularHumanSignal TransductionNecroptosiCYTOCHROME-C RELEASEOUTER-MEMBRANE PERMEABILIZATIONProgrammed cell deathCIENCIAS MÉDICAS Y DE LA SALUDSettore BIO/06Inmunología610 Medicine & healthCELL DEATHNOQ-VD-OPH03 medical and health sciencesSettore MED/04 - PATOLOGIA GENERALEddc:570Terminology as TopicAPOPTOSIS-INDUCING FACTORMIXED LINEAGE KINASEmedicineAnimalsHumansAnimals; Humans; Terminology as Topic; Apoptosis; Signal Transduction; Molecular Biology; Cell BiologyMorphologic Aspects of Cell DeathSettore BIO/10Molecular Biology030304 developmental biologyAnimalCell growthApoptosiBiology and Life SciencesCell Biologymedicine.diseaseMITOCHONDRIAL PERMEABILITY TRANSITIONApoptosisImmunologybiology.proteinNeurosciencedescription
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ?accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. "Regulated cell death" (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Nomenclature Committee on Cell Death. Equipe 11 Apoptose, Cancer et Immunité. Centre de Recherche des Cordeliers; Francia
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Cell death and differentiation |