Search results for "mores"
showing 10 items of 77 documents
Tumor pardo en la sínfisis mandibular como primera manifestación clínica de hiperparatiroidismo: diagnóstico y tratamiento
2005
El tumor pardo es una de las lesiones óseas que pueden encontrarse en pacientes con hiperparatiroidismo. Pueden localizarse en cualquier hueso, afectando ocasionalmente al territorio craneo- maxilofacial. Si bien en la mayoría de los casos el diagnóstico de tumor pardo se realiza en pacientes en los que se ha diagnosticado previamente el hiperparatiroidismo, en ocasiones éste puede ser el primer signo de la enfermedad. Presentamos un caso de tumor pardo localizado en la sínfisis mandibular que fue el primer signo clínico de hiperaparatiroidismo secundario a un adenoma paratiroideo hiperfuncionante. Se revisan el diagnóstico diferencial de este tipo de lesiones y sus posibles tratamientos. B…
Prevención y atención de las necesidades educativas especiales de los niños con tumores intracraneales
2000
Se describen las necesidades educativas especiales de los niños con tumores intracraneales en función e la localización y naturaleza del tumor y de los tratamientos.
Patología de los tumores neuroblásticos: evaluación pronóstica. Experiencia del centro español de referencia de la SEOP para estudios biopatológicos …
2007
Antecedentes: Los tumores neuroblásticos son los tumores sólidos extracraneales más frecuentes en la infancia y se caracterizan por una evolución clínica heterogénea que va desde una progresión rápida a una regresión tumoral espontánea. Existen factores pronósticos conocidos que determinan dicha evolución como son la edad, estadiaje, histopatología, estatus de MYCN, ploidía y diversas ganancias y pérdidas cromosómicas. El objetivo del trabajo es describir nuestra experiencia como laboratorio de referencia español para la determinación de estos parámetros pronósticos. Métodos: Material tumoral de pacientes con neuroblastoma, remitido a nuestro laboratorio desde 1992 hasta 2005, ha sido somet…
Tumoresferas como plataformas de cribado farmacológico in vitro/in vivo para la búsqueda de nuevas terapias contra el cáncer de pulmón no microcítico
2020
El cáncer de pulmón es el tumor con mayor mortalidad a nivel mundial, y en concreto el cáncer de pulmón no microcítico (CPNM) comprende más del 80% de los casos. Actualmente, los fármacos más empleados en este tipo de cáncer son los quimioterápicos; sin embargo, la adquisición de resistencia a estos compuestos limita en gran medida la eficacia de los tratamientos. Dentro de las diferentes poblaciones celulares presentes en el microambiente tumoral se encuentran las células madre tumorales (CMTs), encargadas de la proliferación y diferenciación, estas células tienen capacidad de latencia y poca respuesta a los tratamientos empleados actualmente en la práctica clínica, por tanto, responsables…
Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole derivatives: as anticancer and antibiofilm agents, and preclinical invest…
2020
Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment
2021
Despite the recent advances in cancer patient management and in the development of targeted therapies, systemic chemotherapy is currently used as a first-line treatment for many cancer types. After an initial partial response, patients become refractory to standard therapy fostering rapid tumor progression. Compelling evidence highlights that the resistance to chemotherapeutic regimens is a peculiarity of a subpopulation of cancer cells within tumor mass, known as cancer stem cells (CSCs). This cellular compartment is endowed with tumor-initiating and metastasis formation capabilities. CSC chemoresistance is sustained by a plethora of grow factors and cytokines released by neighboring tumor…
Immunotherapy targeting colon cancer stem cells
2010
In the last 10 years, cancer stem cells have interested the scientific community because this small tumorigenic population is also associated with tumor progression in human patients and specific targeting of cancer stem cells could be a strategy to eradicate cancers currently resistant to conventional therapy. Clinical studies have recently demonstrated that adding immune therapy to chemotherapy has survival benefits in comparison with chemotherapy alone that can sensitize tumors to immune cell-mediated killing (e.g., increasing sensitivity of tumor cells to subsequent cytotoxicity by T cells via upregulation of death receptors DR5 and Fas). However, loss of MHC molecules is often observe…
Prognostic Impact of let-7e MicroRNA and Its Target Genes in Localized High-Risk Intestinal GIST: A Spanish Group for Research on Sarcoma (GEIS) Study
2020
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between relapsed and non-relapsed patient samples, which were validated in the expansion set, by qRT-PCR. RT2 Profiler PCR Array was used for the screening of let-7e targets. Expression levels were co…
Tailoring Properties of Carbon Nanotube Dispersions and Nanocomposites Using Temperature-Responsive Copolymers of Pyrene-Modified Poly(N-cyclopropyla…
2010
Despite their immense potential, the ability to control the dispersion and microstructure of carbon nanotubes remains a hurdle for their widespread use. Stimuli-responsive polymers show conformational changes with an applied external stimulus (pH, temperature, light, etc.). The dispersion of carbon nanotubes by thermoresponsive polymers is shown to enable the macroscopic properties of aqueous suspensions to be tailored as a function of temperature. This work presents the synthesis, characterization, and use of temperature-responsive poly(N-cyclopropylacrylamide) (PNCPA) polymers containing 1, 3, and 5 mol % pyrene-bearing repeat units to tailor the dispersion state of single-walled carbon n…
How Structure-Related Collapse Mechanisms Determine Nanoscale Inhomogeneities in Thermoresponsive Polymers
2012
Continuous wave electron paramagnetic resonance (CW EPR) spectroscopy on the amphiphilic spin probe TEMPO in solutions of selectively chosen functional, thermoresponsive poly(propylene oxide) (PPO)- and poly(ethylene oxide) (PEO)-based copolymers of both linear and branched structure is used to elucidate their host–guest interactions and inverse phase transitions. Three different fundamental types of host–guest interactions between probes and polymers could be correlated to the phase transition mechanisms (supported by MD simulations), evidencing that these proceed via nanoscale inhomogeneities of the polymers. Because of their ability to host small amphiphilic guest molecules, thermorespon…