Search results for "morpholine"
showing 10 items of 93 documents
CCDC 1009522: Experimental Crystal Structure Determination
2015
Related Article: Pavel V. Gushchin, Maxim L. Kuznetsov, Matti Haukka, and Vadim Yu. Kukushkin|2014|J.Phys.Chem.A|118|9529|doi:10.1021/jp506256a
CCDC 1875521: Experimental Crystal Structure Determination
2018
Related Article: Artis Kinens, Simonas Balkaitis, and Edgars Suna|2018|J.Org.Chem.|83|12449|doi:10.1021/acs.joc.8b01687
CCDC 2104299: Experimental Crystal Structure Determination
2021
Related Article: Peter Happ, Christian Plenk, Eva Rentschler|2015|Coord.Chem.Rev.|289-290|238|doi:10.1016/j.ccr.2014.11.012
Synthesis, UV/vis, FT-IR and Mössbauer spectroscopic characterization and molecular structure of the Bis[4-(2-aminoethyl)morpholine](tetrakis(4-metox…
2016
International audience; The synthesis, the UV-visible, FT-IR and Mossbauer spectroscopy and the crystal structure characterizations of the bis[4-(2-Aminoethyl)morpholine]tetrakis(4-metoxyphenyl)porphy-rinato)iron(II) complex are described. The title compound crystallizes in the triclinic, space group P-1, with a = 11.1253(4) angstrom, b = 11.2379(4) angstrom, c = 11.5488(4) angstrom, alpha = 72.304(2)degrees, beta = 86.002(2)degrees gamma = 72.066(2)degrees, V = 1308.28(8) angstrom(3), Z = 1. The Mossbauer data are consistent with an iron(II) low-spin (S = 0) porphyin species. The spin-state is confirmed by the value of the average equatorial iron-nitrogen pyrrole distance (Fe-Np = 1.988(2)…
Application of tris-allyl-DOTA in the preparation of DOTA–peptide conjugates
2006
Abstract The synthesis of tris-allyl-DOTA starting from cyclen and its application in the preparation of DOTA–peptide conjugates is reported. Clinically important conjugates such as DOTA–Tyr3-octreotide (DOTA–TOC), DOTA–Tyr3-octreotate (DOTA–TATE) as well as a DOTA–RGD peptide were synthesized in high yields with Fmoc solid phase peptide synthesis. The final, extremely reliable de-allylation was achieved on solid phase by different methods identifying morpholine/Pd(0) as the most suitable one obtaining all DOTA peptide conjugates in high yields. All DOTA–peptides were purified by reversed phase HPLC and structural identity was proved using MALDI-TOF mass spectrometry.
Influence of photo-initiators in the preparation of methacrylate monoliths into poly(ethylene-co-tetrafluoroethylene) tubing for microbore HPLC.
2020
[EN] In this study, poly(butyl methacrylate-co-ethyleneglycol dimethacrylate) polymeric monoliths were in situ developed within 0.75 mm i.d. poly(ethylene-co-tetrafluoroethylene) (ETFE) tubing by UV polymerization via three different free-radical initiators fscce-azobisisobutyronitrile (AIBN), 2,2-dimethoxy-2-phenylacetophenone (DMPA) and 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMPP). The influence of the nature of each photo-initiator and irradiation time on the morphological features of the polymer was investigated by scanning electron microscopy, and the chromatographic properties of the resulting microbore columns were evaluated using alkyl benzenes as test substances. The …
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.
2010
BACKGROUND: Meprin metalloproteases are thought to be involved in basic physiological functions such as cell proliferation and tissue differentiation. However, the specific functions of these enzymes are still ambiguous, although a variety of growth factors and structural proteins have been identified as meprin substrates. The discovery of meprins alpha(1), alpha(2) and beta in teleost fish provided the basis for uncovering their physiological functions by gene silencing in vivo. METHODOLOGY/PRINCIPAL FINDINGS: A Morpholino knockdown in zebrafish embryos targeting meprin alpha(1) and beta mRNA caused defects in general tissue differentiation. But meprin alpha(2) morphants were affected more…
Uranyl(VI) complexes with a diaminobisphenol from eugenol and N-(2-aminoethyl)morpholine: Syntheses, structures and extraction studies
2011
Abstract The syntheses and structural studies of an [O,N,O,N′]-type phenolic ligand [(N’,N’-bis(2-hydroxy-3-methoxy-5-(propen-2-yl)benzyl)-N-(2-aminoethyl)morpholine), (H2L) and two new uranyl complexes of this ligand are described. The reaction between uranyl nitrate hexahydrate and H2L in a 1:2 M ratio (M to H2L) results in a uranyl complex of the formula [UO2(HL)(NO3)(H2O)] (1). In the presence of a base (triethylamine), with the same molar ratio, the uranyl complex [UO2(HL)2]·2CH3CN (2) is formed. The molecular structures H2L, 1 and 2 were verified by X-ray crystallography. Both uranyl complexes are zwitterions with a neutral net charge. A comprehensive NMR-structural analyses of all co…
Synthese von geschützten Asparagin-Glycopeptiden durch N-terminale Peptidketten- Verlängerung. _ Teilsequenzen der Rinder-Desoxyribonuclease A und de…
1983
N-[2-(Triphenylphosphonio)ethoxycarbonyl] -[Peoc-]asparaginsaure-benzylester (8h) und -tert-butylester (8i) werden mit 2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-β -D-glucopyranosylamin (2) zu den N4-Glycosylasparagin-Derivaten 19 verknupft. Aus diesen kann die Peoc-Gruppe selektiv mit Diethylamin/tert-Butylalkohol oder Morpholin/Methylendichlorid abgespalten werden, wobei in den entstandenen N4-Glycosylasparaginestern 22 alle anderen Schutzgruppen und die glycosidische Bindung erhalten bleiben. Durch Kondensation von 22 mit Peoc-Aminosauren 8 entstehen die voll geschutzten N4-Glycosylasparagin-Dipetide 24 und 30. Bei Kondensation der N2 deblockierten N4-Glycosylasparaginester 22 mit den Peoc-…
ChemInform Abstract: The Allyl Ester as Carboxy-Protecting Group in the Stereoselective Construction of Neuraminic Acid Glycosides.
1989
The application of the allyl-ester moiety as protecting principle for the carboxy group of N-acetylneuraminic acid is described. Peracetylated allyl neuraminate 2 is synthesized by reacting the caesium salt of the acid 1 with allyl bromide. Treatment of 2 with HCl in AcCl or with HF/pyridine gives the corresponding 2-chloro or 2-fluoro derivatives 3 and 4, respectively (Scheme 1). In the presence of Ag2CO3, the 2-chloro carbohydrate 3 reacts with di-O-isopropylidene-protected galactose 5 to give the 2–6 linked disaccharide with the α-D-anomer 6a predominating (α-D/β-D = 6:1; Scheme 2). Upon activation of the 2-fluoro derivative 4 with BF3 · Et2O, the β-D-anomer 6b is formed preferentially (…