Search results for "morpholine"

showing 10 items of 93 documents

Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination

2022

Disruption or loss of oligodendrocytes (OLs) and myelin has devastating effects on CNS function and integrity, which occur in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease and neuropsychiatric disorders. Hence, there is a need to develop new therapies that promote oligodendrocyte regeneration and myelin repair. A promising approach is drug repurposing, but most agents have potentially contrasting biological actions depending on the cellular context and their dose-dependent effects on intracellular pathways. Here, we have used a combined systems biology and neurobiological approach to identify compounds that exert positive and negative effects on olig…

MyelinMiceMyelin SheathNSC Neural stem cellSystems BiologyOPC Oligodendrocyte progenitor cellHigh-Throughput Nucleotide SequencingLINCS The Library of Integrated Network-based Cellular SignaturesCell DifferentiationGeneral MedicineCNS Central Nervous SystemOligodendrogliamedicine.anatomical_structureOligodendrogenesisNFOL Newly formed oligodendrocyteOL OligodendrocyteSignal TransductionSubventricular zoneOptic nerveIn silicoSystems biologyMorpholinesSVZ subventricular zoneContext (language use)RM1-950BiologyArticlemedicinePharmacogenomics The Library of Integrated Network-Based Cellular Signatures/LINCSAnimalsH-LY29 High concentration of LY294002Computer SimulationPI3K/AKT/mTOR pathwayL-LY29 Low concentration of LY294002PharmacologyPI3K/AktTCN TriciribineDose-Response Relationship DrugRegeneration (biology)Multiple sclerosismedicine.diseaseOligodendrocyteOligodendrocyteiNSCs iPSC-derived NSCsTAPs Transiently amplifying progenitorsMice Inbred C57BLMS Multiple SclerosisiPCS induced Pluripotent Stem CellChromonesPharmacogeneticsTherapeutics. PharmacologyMOL Myelinating oligodendrocyteNeuroscienceBiomedicine & Pharmacotherapy
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CCDC 1875521: Experimental Crystal Structure Determination

2018

Related Article: Artis Kinens, Simonas Balkaitis, and Edgars Suna|2018|J.Org.Chem.|83|12449|doi:10.1021/acs.joc.8b01687

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdichloro-bis(morpholine)-zinc(ii)Experimental 3D Coordinates
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CCDC 2245212: Experimental Crystal Structure Determination

2023

Related Article: Milla Mattila, Kari Rissanen, Jas S. Ward|2023|Chem.Commun.|59|4648|doi:10.1039/D3CC00259D

Space GroupCrystallographyCrystal SystemCrystal Structure4-(pyridin-4-yl)morpholineCell ParametersExperimental 3D Coordinates
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CCDC 1407242: Experimental Crystal Structure Determination

2016

Related Article: Rakesh Puttreddy, Ngong Kodiah Beyeh, Kari Rissanen|2016|CrystEngComm|18|793|doi:10.1039/C5CE02354H

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters281420-tetraethyl-5111723-tetramethylpentacyclo[19.3.1.137.1913.11519]octacosa-1(25)3(28)469(27)101215(26)16182123-dodecaene-46101216182224-octol bis(4-methylmorpholine 4-oxide) methanol solvateExperimental 3D Coordinates
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CCDC 1009523: Experimental Crystal Structure Determination

2015

Related Article: Pavel V. Gushchin, Maxim L. Kuznetsov, Matti Haukka, and Vadim Yu. Kukushkin|2014|J.Phys.Chem.A|118|9529|doi:10.1021/jp506256a

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(N-phenyl-N-(N'-phenylcarbamimidoyl)morpholine-4-carboximidamide)-platinum(ii) dichloride ethanol solvateExperimental 3D Coordinates
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CCDC 2022360: Experimental Crystal Structure Determination

2021

Related Article: Abdullah Mohammed Al-Majid, Matti Haukka, Saied M. Soliman, Abdullah Saleh Alamary, Saeed Alshahrani, M. Ali, Mohammad Shahidul Islam, Assem Barakat|2021|Symmetry|13|20|doi:10.3390/sym13010020

44'-(ethane-12-diyl)bis(morpholine)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2032478: Experimental Crystal Structure Determination

2021

Related Article: Stephan P. Blum, Tarik Karakaya, Dieter Schollmeyer, Artis Klapars, Siegfried R. Waldvogel|2021|Angew.Chem.,Int.Ed.|60|5056|doi:10.1002/anie.202016164

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters4-(345-trimethoxybenzene-1-sulfonyl)morpholineExperimental 3D Coordinates
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CCDC 2068111: Experimental Crystal Structure Determination

2021

Related Article: Shilin Yu, Jas S. Ward, Khai-Nghi Truong, Kari Rissanen|2021|Angew.Chem.,Int.Ed.|60|20739|doi:10.1002/anie.202108126

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters4-{1-[(benzoyloxy)-iodanyl]-1-pyridin-4-yl}morpholineExperimental 3D Coordinates
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CCDC 1009522: Experimental Crystal Structure Determination

2015

Related Article: Pavel V. Gushchin, Maxim L. Kuznetsov, Matti Haukka, and Vadim Yu. Kukushkin|2014|J.Phys.Chem.A|118|9529|doi:10.1021/jp506256a

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(N-phenyl-N-(N'-phenylcarbamimidoyl)morpholine-4-carboximidamide)-platinum(ii) dichloride methanol solvateExperimental 3D Coordinates
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CCDC 2104299: Experimental Crystal Structure Determination

2021

Related Article: Peter Happ, Christian Plenk, Eva Rentschler|2015|Coord.Chem.Rev.|289-290|238|doi:10.1016/j.ccr.2014.11.012

Space GroupCrystallographytetrakis(mu3-salicylhydroximato-NOOO'O'')-(mu-2-benzoxazolinonato-NO)-(mu2-pivalato-OO')-pentakis(morpholine-N)-(methanol-O)-cobalt(ii)-tetra-cobalt(iii) methanol solvate monohydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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