Search results for "movement"
showing 10 items of 2021 documents
Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
2011
SummaryTuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartomatous neurological lesions that exhibit abnormal cell proliferation and differentiation. Hyperactivation of mTOR pathway by mutations in either the Tsc1 or Tsc2 gene underlies TSC pathogenesis, but involvement of specific neural cell populations in the formation of TSC-associated neurological lesions remains unclear. We deleted Tsc1 in Emx1-expressing embryonic telencephalic neural stem cells (NSCs) and found that mutant mice faithfully recapitulated TSC neuropathological lesions, such as cortical lamination defects and subependymal nodules (SENs). These alterations were caused by enhanced gen…
Novel triplet of flexor muscles in the posterior tentacles of the snail, Helix pomatia.
2012
The anatomy of three novel flexor muscles in the posterior tentacles of Helix pomatia is described. The muscles originate from the ventral side of the sensory pad and are anchored at different sites in the base of the tentacle stem. The muscles span the tentacle and always take the length of the stem which depends on the rate of tentacle protrusion indicating that the muscles are both contractile and extremely stretchable. The three anchoring points at the base of the stem determine three space axes along which the contraction of a muscle or the synchronous contraction of the muscles can move the tentacle in space.
LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation.
2003
Abstract A new lipidic acid-amido ether derivative (LAAE-14) able to reduce dose-dependently the calcium increases mediated either by calcium ionophore ionomycin, by the endoplasmic reticular Ca 2+ -ATPase inhibitor thapsigargin, or by the chemotactic tripeptide N -formyl- l -methionyl- l -leucyl- l -phenylalanine (fMLP), in human neutrophils as well as in murine peritoneal macrophages, but not ATP, has been evaluated as a potential anti-inflammatory drug. This compound attenuated leukocyte activation by means of its inhibitory effect on the respiratory burst elicited in both types of cells by 12- O -tetradecanoyl phorbol 13-acetate, by inhibition of the degranulation process induced by cyt…
Free movement of services in the European Union and in the Eurasian Economic Union. Similarities and differences
2017
The European Union (EU) and the Eurasian Economic Union (EAEU) are international organizations integrating member states, primarily in the economic field. Both organizations guarantee four economic freedoms: free movement of goods, services, labor, and capital. One of these freedoms:free movement of services is particularly important. It should be noted that within the customs union of the EU and the EAEU the internal customs barriers have been eliminated, and for the exchange of services between these organizations, only the borders between the two unions remain an obstacle. For this reason, legal regulations concerning the free movement of services in the EU and the EAEU determine the opp…
Narrativa dei Caraibi nel nuovo millennio
2020
L’etichetta “Letterature franco-caraibica” utilizzata, per convenzione, dalla critica per indicare unitariamente la produzione letteraria in lingua francese della regione centrale del Continente americano è assai impropria. La regione dei Caraibi abbraccia, infatti, sia alcune delle isole dell’arcipelago delle Piccole Antille (Martinica, Guadalupa), sia l’isola di Haïti, che fa parte delle Grandi Antille, che la Guiana incastonata sulla costa orientale dell’America meridionale. Pur nella diversità dei movimenti ideologici e degli avvenimenti storici che si sono succeduti nella regione, le opere letterarie degli scrittori caraibici francofoni, nel loro insieme, hanno oscillato, e continuano …
Caraibi: un "archipel inachevé"
2018
L’etichetta “Letterature franco-caraibica” utilizzata, per convenzione, dalla critica per indicare unitariamente la produzione letteraria in lingua francese della regione centrale del Continente americano è assai impropria. La regione dei Caraibi abbraccia, infatti, sia alcune delle isole dell’arcipelago delle Piccole Antille (Martinica, Guadalupa), sia l’isola di Haïti, che fa parte delle Grandi Antille, che la Guiana incastonata sulla costa orientale dell’America meridionale. Pur nella diversità dei movimenti ideologici e degli avvenimenti storici che si sono succeduti nella regione, le opere letterarie degli scrittori caraibici francofoni, nel loro insieme, hanno oscillato, e continuano …
NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins.
2013
The transmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells (OPC), which migrate to axons during developmental myelination and remyelinate in the adult after migration to injured sites. Highly invasive glial tumors also express NG2. Despite the fact that NG2 has been implicated in control of OPC migration, its mode of action remains unknown. Here, we show in vitro and in vivo that NG2 controls migration of OPC through the regulation of cell polarity. In stab wounds in adult mice we show that NG2 controls orientation of OPC toward the wound. NG2 stimulates RhoA activity at the cell periphery via the MUPP1/Syx1 signaling pathway, which favors the bipolar shape of migrat…
Effect of Standard Disk Plough on Soil Translocation in Sloping Sicilian Vineyards
2022
Tillage is the main force of soil redistribution in agricultural land use and has been seen as more critical than water erosion. This study aims to evaluate the effect of tillage with standard disk in vineyards. A representative study area with grapevines was selected, and 39 inter-rows were selected to test the effect of slope and forward speed. In each inter-row, a strip of soil was collected, and mixed with 2 kg of coloured sand used as a tracer, then replaced in the strip, and shallow soil tillage was performed by means of a standard disk plough. Three soil subsamples were collected along the slope every 0.30 m from the coloured strip and the sand tracer was separated from the soil and …
Modeling of Resonance Phenomena in Self-Oscillating System of Agricultural Machines
2021
Factors affecting the interaction of the active cultivator paw with the soil environment are considered in this article. It was established that the active oscillating effect of tillage machines on the environment leads to reduction in its traction characteristics, and the design of symmetrical movable paw is capable of self-oscillation in a horizontal plane. It was developed the theoretical model of oscillatory movements that takes into account the main structural parameters of working bodies represented by symmetrical cultivator paws of the active type. For laboratory studies, a circular soil channel is used, which ensures the movement of the soil relative to the stationary working body f…
Software tools for using a personal computer as a timer device to assess human kinematic performance: a case study.
1995
Frequently, the assessment of the physical condition of a sportsman depends on the evaluation of different tests, based on biomechanical performance. The data acquisition in these tests is usually hand made, because its automatization is difficult. But when movements are constrained by means of their specific nature, simple tools can be used to achieve that data acquisition. In this paper, a simple and inexpensive system is described to make use of the timing capabilities of a personal computer (PC) to use it as a timer, with applications in biomechanics and sport training. The data acquisition method is based on a PC that, using a specific programming dealing with event timing, gets signal…