Search results for "multiple"
showing 10 items of 2678 documents
Analysis of 29 Y-chromosome SNPs in a single multiplex useful to predict the geographic origin of male lineages
2006
Abstract The European Consortium “High throughput analysis of single nucleotide polymorphisms for the forensic identification of persons—SNPforID” has performed a selection of candidate Y-chromosome SNPs (single nucleotide polymorphisms) for making inferences on the geographic origin of an unknown sample. A “Major Y chromosome haplogroup typing kit” has been developed, which allows the multiplex amplification of 29 SNPs in a single reaction followed by a single base extension (SBE) reaction (minisequencing) and separation of the resulting extension products by capillary electrophoresis.
Exploring the generative power of performance measurement systems design
2019
Abstract Prior studies recognise the enabling power of incompleteness in the design of Performance Measurement Systems (PMS). We add to these studies by exploring the ‘time dimension’ of incompleteness as a way to delve into the generative power of design. To this aim, we rely upon the experience of a knowledge-intensive organization during the design of a new PMS. While knowledge complexity engaged the participants within an open-ended design process, incomplete measures were associated with unfolding memories of the past and confident beliefs in future solutions, which generated effects through the knowledge gaps that they entailed, as well as through the projections in the past and in th…
Wireless OFDM-OQAM with a small number of subcarriers
2008
Orthogonal frequency division multiplexing based on offset quadrature amplitude modulation (OFDM-OQAM) is a multicarrier signaling technique which trades off robustness for spectral efficiency when compared to conventional OFDM with a cyclic prefix. In this paper, a novel matrix model for passband OFDM-OQAM signaling with a small number of subcarriers over a multipath frequency selective fading channel is presented. Specifically, in OFDM-OQAM a frequency selective channel is divided into many smaller but still frequency selective overlapping channels, so approximating the frequency response of a subchannel by the channel frequency response sampled at the subcarrier frequency may be inadequa…
A simple joint estimation-detection technique for OFDM systems
2005
In this work a simple approach for the joint estimation-detection in a frequency selective severe fading environment of OFDM signals adopting PSK constellations is presented. A linear predictor of suitable order is adopted for the channel estimation in the frequency domain. The predictor coefficients are estimated on the basis of a sample estimation of the autocorrelation of the channel frequency response, aided by a preliminary differential decoding, in a blockwise manner. The detection technique proposed here is based on a simple tree search where a small number of best survivor paths are maintained at each step. Despite the simplicity of above detection approach, the simulation results s…
Maximizing network capacity in an heterogeneous macro-micro cellular scenario
2011
The problem of resource allocation in cellular networks has been traditionally faced at two different levels: at the network level, in terms of frequency planning and reuse pattern design, and at the cell level, in terms of cell capacity optimizations based on channel-dependent scheduling, link adaptation, power control, and so on. While this second aspect has been deeply investigated in literature, the first aspect has been mainly faced with static or semi-dynamic reuse utilization solutions. In this paper we deal with the problem of multi-cellular resource allocation in heterogeneous OFDMA environments with reuse factor equal to 1, where base stations with different power constraints coex…
Rapid PCR-based test for identifying Candida albicans by using primers derived from the pH-regulated KER1 gene.
2006
A PCR-based method in combination with a simple, reliable and inexpensive DNA extraction procedure for rapid detection of Candida albicans clinical isolates is described here. The extraction protocol is based on a combination of chemical (NaOH and detergents) and physical (boiling) treatments, thus avoiding many of the problems inherent in the currently available DNA extraction protocols (basically the use of expensive and/or toxic chemical reagents), and may be useful for daily clinical routine. The PCR-based system described here uses a single pair of primers (SC1F and SC1R) deduced from the C. albicans-specific KER1 gene sequence. These primers amplify a 670-bp fragment of the KER1 gene.…
Prevalence of Apical Periodontitis in patients with Multiple Myeloma
2020
Background Aim Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. Material and Methods Methodology Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by 2 two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical…
An integrated fuzzy cells-classifier
2007
This paper introduces a genetic algorithm able to combine different classifiers based on different distance functions. The use of a genetic algorithm is motivated by the fact that the combination phase is based on the optimization of a vote strategy. The method has been applied to the classification of four types of biological cells, results show an improvement of the recognition rate using the genetic algorithm combination strategy compared with the recognition rate of each single classifier.
Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma
2021
Abstract Immune therapies including CAR T cells and bispecific T cell engagers are demonstrating remarkable efficacy in relapsed refractory myeloma (MM). In this context, we have recently shown that proteasome inhibitor bortezomib (BTZ) results in immunogenic cell death (ICD) and in a viral mimicry state in MM cells, allowing for immune recognition of tumor cells. Induction of a robust anti-MM immune response after BTZ was confirmed both in vitro and in vivo: treatment of 5TGM1 MM cells with BTZ induced tumor regression associated with memory immune response, confirmed by ELISPOT of mouse splenocytes. We have confirmed the obligate role of calreticulin (CALR) exposure in phagocytosis and th…
Indium surfactant effect on AlN/GaN heterostructures grown by metal-organic vapor-phase epitaxy: Applications to intersubband transitions
2006
We report on a dramatic improvement of the optical and structural properties of AlN/GaN multiple quantum wells (MQWs) grown by metal-organic vapor-phase epitaxy using indium as a surfactant. This improvement is observed using photoluminescence as well as x-ray diffraction. Atomic force microscopy shows different surface morphologies between samples grown with and without In. This is ascribed to a modified relaxation mechanism induced by different surface kinetics. These improved MQWs exhibit intersubband absorption at short wavelength (2 mu m). The absorption linewidth is as low as 65 meV and the absorption coefficient is increased by 85%.