Search results for "multiple"
showing 10 items of 2678 documents
Elementos para uma nova reflexão sobre a escola primaria em meio rural
1995
International audience
A chaque classe ses élèves : procédures et critères d'affectation à l'école élémentaire
2005
This paper examines the class formation procedures used in French elementary schools, specially when combination classes (with two grade levels) occur. Principals were interviewed about pupils' assignment criteria and at the same time, the class distributional properties of 70 classes were analysed. The results confirm that pupils are sorted into classrooms based on a combination of individual criteria, including gender and academic achievement, in an effort to keep to the initial mix of children. Moreover, principal and teachers assign more independent students to combination classes to ease the burden they place on teachers. These purposeful assignment procedures, which integrate academic…
Ablagerung von gadoliniumhaltigen Kontrastmitteln im Gehirn nach mehrfacher Anwendung: Konsequenzen für den Einsatz der MRT bei Diagnosestellung und …
2016
Neue Studienergebnisse weisen auf einen Zusammenhang zwischen wiederholten kontrastmittel-unterstutzen MRT-Untersuchungen und Ablagerung gadoliniumhaltiger Kontrastmittel im zentralen Nervensystem hin. Ein wesentlicher Faktor hierbei stellt moglicherweise die zum Einsatz kommende Kontrastmittelsubstanzklasse (linear bzw. makrozyklisch) dar. Uber die letzten Jahrzehnte hat sich die MRT als ein unverzichtbarer Bestandteil in der Diagnostik, aber auch in der Verlaufsbeurteilung unterschiedlicher Erkrankungen etabliert. Dies gilt im besonderen Mase fur chronische Erkrankungen, wie die Multiple Sklerose. Wiederholte MRT-Untersuchungen spielen hier insbesondere durch die zunehmenden Therapieoptio…
Observatoire francophone des néoplasies endocriniennes multiples de type 1. Un outil du Groupe d'étude des Tumeurs Endocrines (GTE)
2007
Wermer's syndrome or Multiple Endocrine Neoplasia Type-1 (MEN1) is an autosomal dominant inherited disease, related to mutations in MEN1, an approximately 10-kb gene encoding menin, localized on chromosome 11q13. The Endocrine Tumor Group (GTE) has set up a MEN1 observatory of 1001 regularly followed MEN1 cases. This observatory aims at registering and evaluating MEN1 cases in a large cohort. Any new study on a particular unexplored aspect of the disease may be proposed by a physician to the GTE. This article describes the way to diagnose a new MEN1 case and to register it. Procedures for participating in a new study are presented. Some original results are quoted.
Therapieziele von Basis- und Eskalationstherapien zur Behandlung der schubförmig-remittierenden Multiplen Sklerose
2012
Vor dem Hintergrund der Verfugbarkeit neuer, hochwirksamer MS-Therapeutika und der besonderen Bedeutung des fruhen Krankheitsverlaufs fur die Prognose der MS kommt der Definition von Therapiezielen starkere Bedeutung zu. Insbesondere die Erstellung von Kriterien fur eine rechtzeitige Eskalationstherapie bei MS-Patienten ist eine relevante Frage der alltaglichen Versorgung. Leider fehlen fur diese Fragestellung Studienergebnisse mit Klasse-I-Evidenz. Im Rahmen eines industrieunterstutzten Expertenmeetings wurden Therapieziele von immunmodulatorischen Basis- und Eskalationstherapien fur Patienten mit schubformig-remittierender MS und Kriterien fur die rechtzeitige Umstellung auf Eskalationsth…
Within-host interactions shape virulence-related traits of trematode genotypes
2019
Within‐host interactions between co‐infecting parasites can significantly influence the evolution of key parasite traits, such as virulence (pathogenicity of infection). The type of interaction is expected to predict the direction of selection, with antagonistic interactions favouring more virulent genotypes and synergistic interactions less virulent genotypes. Recently, it has been suggested that virulence can further be affected by the genetic identity of co‐infecting partners (G × G interactions), complicating predictions on disease dynamics. Here, we used a natural host–parasite system including a fish host and a trematode parasite to study the effects of G × G interactions on infection…
L’habitat et la nécropole du Haut Moyen Âge du lieu-dit Le Moulin Vaquet à Honguemarre-Guenouville (Eure) : un « village prénormand » du plateau du R…
2010
Sur le plateau du Roumois, le lieu-dit Moulin Vaquet à Honguemare-Guenouville (Eure) était occupé entre le VIIe et le Xe siècle par un village, habitat rural polarisé autour d’une nécropole probablement dominée par une église de bois. La fouille de ce site par la MADE sur 8 600m2 complète celle de l’INRAP à quelques centaines de mètres. Between the 7th and 10th centuries, the “Moulin Vaquet"site, near Honguemare-Guenouville (Eure) on the Roumois Plateau, was occupied by a village – a rural settlement built around a necropolis, likely dominated by a wooden church. The 8,600m2 excavation of the site run by MADE (the Eure archaeological mission) complements the INRAP excavations a few hundred …
Synthesis and induction of G0–G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazep…
2007
The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one 15 has been carried out. The compound showed antiproliferative and apoptotic effects against K562, K562-R (imatinib mesilate resistant), HL60 and multidrug resistant (MDR) HL60 cell lines. Compound 15 showed a pro-apoptotic activity against HL60 and K562 resistant cell lines markedly higher than etoposide and busulfan, respectively. Flow cytometry studies carried out on K562 cells allowed to establish that 15 induces G0-G1 phase arrest followed by apoptosis.
A readout unit for high rate applications
2002
The LHCb readout unit (RU) is a custom entry stage to the readout network of a data-acquisition or trigger system. It performs subevent building from multiple link inputs toward a readout network via a PCI network interface or alternatively toward a high-speed link, via an S-link interface. Incoming event fragments are derandomized, buffered and assembled into single subevents. This process is based on a low-overhead framing convention and matching of equal event numbers. Programmable logic is used both in the input and output stages of the RU module, which may be configured either as a data-link multiplexer or as entry stage to a readout or trigger network. All FPGAs are interconnected via…
Cardiovascular risk in patients without known cardiovascular disease.
2014
Understanding the risks of atherosclerotic cardiovascular disease (CVD) allows for better patient education and management. Multiple risk models have been validated in large patient populations and provide insights into the risks associated with CVD. When assessing such risks, we suggest using a model that predicts myocardial infarction, cardiovascular death, and/or cerebrovascular events. In this review, we analyze several risk models and stratify the risks associated with CVD. We suggest that appropriate profiling of patients at-risk of CVD will lead to better physician recognition and treatment of modifiable risk factors, appropriate application of ATP III treatment for hyperlipidemia, a…