Search results for "nAChR"
showing 10 items of 20 documents
Lo sguardo dell’altro: artivismo, ideologia e rappresentazione
2020
In a global context in which society has become spectacle, everything turns into representation (Debord 1967). The phenomenon of nation-states fortification emerges in a problematic way with respect to the neoliberal capital-work relationship (Mezzadra e Nielson 2013). The need to build walls, in fact, is a mode of representation that is exploited for a strategic construction of alterity. The aim of this research is to highlight the “naturalization” of stereotyped imagery, prompted by mediatic and political discourses concerning the migratory phenomenon. Starting from a recognition of the critical thinking of scholars such as Michel Foucault and Louis Marin, the goal of this paper is to tak…
Stable expression in HEK-293 cells of the rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor.
1996
The alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) was stably expressed in human embryonic kidney (HEK) 293 cells that co-expressed a voltage-gated Ca2+ channel. alpha3/beta4-nAChR-expressing clones were identified using the fura-2 Ca2+ imaging technique, and were further characterised by single-cell and whole-cell patch-clamp studies. Acetylcholine (ACh) induced fast activating currents which showed desensitisation and inward rectification. The conductance of the ACh-activated channel was 29 pS. The order of potency of the nicotinic agonists tested was cytisine approximately = nicotine > acetylcholine. The EC50 value for ACh was 145 microM; the Hill coefficient w…
SUBJECTIVITY AS A NON-TEXTUAL STANDARD OF INTERPRETATION IN THE HISTORY OF PHILOSOPHICAL PSYCHOLOGY
2010
Contemporary caution against anachronism in intellectual history, and the currently momentous theoretical emphasis on subjectivity in the philosophy of mind, are two prevailing conditions that set puzzling constraints for studies in the history of philosophical psychology. The former urges against assuming ideas, motives, and concepts that are alien to the historical intellectual setting under study, and combined with the latter suggests caution in relying on our intuitions regarding subjectivity due to the historically contingent characterizations it has attained in contemporary philosophy of mind. In the face of these conditions, our paper raises a question of what we call non-textual (as…
Martinus Garatus Laudensis on Treaties
2004
Introduction Martinus Garatus Laudensis' De confaederatione, pace et conventionibus principum is widely acknowledged as one of the first monographic works on the law of treaties. Whatever the merits of such a characterisation, there is a risk that it may obfuscate some of that work's essential features in its proper legal-historical context. Before considering the substance of the work, it is therefore necessary to consider some of its formal features, if only as a general methodological caveat. Martinus Garatus on the prince and the law Before the second half of the seventeenth century, legal monographs on treaties are scarce. That, of course, does not mean that the rich civil and canon la…
Les Éditions Pyrodactyles ou la nostalgie de la littérature
2014
ACL Nat; National audience; Les Éditions Pyrodactyles est une maison d’édition fictive comprenant un panel d’auteurs inventés par Alice Forge, plasticienne depuis 2009, dans une démarche héritée des univers vertigineux et ludiques de Borges et Perec. Ces textes fantômes sont le prolongement d’œuvres réelles, souvent issues de la littérature populaire (Roman d’aventure, roman policier, roman feuilleton et science-fiction). Les auteurs des Éditions Pyrodactyles sont eux-mêmes issus du patrimoine littéraire, inspirés qu’ils sont de personnages romanesques, comme le comte de Monte-Cristo, le capitaine Nemo, Arsène Lupin, etc. S’ajoute à cette littérature une correspondance et une paralittératur…
More Relevant Today Than Ever: Past, Present and Future of Media Performance Research
2020
Media performance is constitutive for functioning democracies. But what is the situation regarding media performance in the age of digitalisation? And how can media performance continue to be assured under the current difficult economic conditions for the news industry? In this essay, we give a short overview of how media performance research has developed from the introduction of private broadcasting to the spread of the Internet and social media. In the course of this development, the initial focus of media performance research on media content has broadened to include media quality from the user perspective. We show how the contributions to this thematic issue relate with existing lines …
Data visualization in Scandinavian newsrooms : emerging trends in journalistic visualisation practices
2018
Abstract The visualization of numeric data is becoming an important element in journalism. In this article, we present an interview study investigating data visualization practices in Scandinavian newsrooms. Editorial leaders, data journalists, developers and graphic designers in 10 major news organizations in Norway, Sweden and Denmark provide information for the study on a range of issues concerning visualization practices and experiences. The emergence of multi-skilled specialist groups as well as innovation in technology and the ‘mobile first mantra’ are identified as important factors in the fast-developing practices of journalistic data visualization. Elements of tension and negotiati…
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
2007
In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms implicated in nicotine addiction and nAChR desensitization. Experimental and clinical data largely indicate long-lasting effects of nicotine and nicotinic agonists that imply a neuroprotective/neurotrophic role of nAChR activation, involving mainly alpha 7 and alpha 4 beta 2 nAChR subtypes, as evidenced using selective nAChR agonists. Compounds interacting with neuronal nAChRs have the potential to be neuroprotective and treatment with nAChR agonists elicits long-lasting neurotrophic e…
Translingual quoting in journalism : behind the scenes of Swiss television newsrooms
2019
This chapter focuses on translingual quoting (TQ), i.e. the subprocess of news-writing by which utterances from sources are both quoted and translated. Analyses of journalists’ mental and material activities suggest conceptualizing TQ as a complex and dynamic activity in which journalists’ individual and collective (e.g., institutional) language awareness, knowledge, and practices interact with multi-layered contexts of text production. Based on this empirically and theoretically grounded concept of TQ, the chapter presents a two-part typology of TQ: In sequential TQ, ready-made media items or interview materials are translated into another language; in parallel TQ, interviews and/or texts …
Aborder la question des violences sexuelles en littérature : perspectives méthodologiques
2022
Ce texte est tiré de la présentation proposée aux côtés de Lucie Nizard et d'Anne-Claire Marpeau lors de la séance « Aborder la question des violences sexuelles en littérature : perspectives méthodologiques » du séminaire « Actualité de la recherche » organisé par le laboratoire POLEN à l'université d'Orléans.