Search results for "noun"
showing 10 items of 234 documents
Ficción y compromiso ontológico
2014
En este trabajo me ocupo de la semántica de los términos de ficción, en el marco de una posición de tipo abstractista (KRIPKE 2011 y 2013, VAN INWAGEN 1977, SALMON 1998 y 2002, THOMASSON 1999, PREDELLI 1997, 2002 y 2005 y VOLTOLINI 2011). En particular, me concentro en dos problemas que afectan a este tipo de posiciones: el primero de ellos es dar cuenta de la verdad intuitiva de enunciados como "Ulises duerme en la playa de Ithaca"; el segundo es explicar la aceptación, también intuitiva, de que "Ulises no existe" es un enunciado verdadero. In this paper I am concerned with a variant of Kripke´s abstractist theory of fiction, namely, the semantic theory according to which proper names and …
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
2020
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…
2016
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…
In vitro effects of vitamins C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell function and redox status in type 1 diabetic pregnant women.
2016
IF 2.972; International audience; The aim of this investigation was to determine the in vitro effects of vitamin C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell proliferation and function in type 1 diabetes. Placenta tissues were collected from 30 control healthy and 30 type 1 diabetic women at delivery. Placental cells were isolated and were cultured in RPMI medium supplemented with vitamin C (50 μM), vitamin E (50 μM), n-3 PUFA (100 μM), n-6 PUFA (100 μM) or n-9 MUFA (100 μM). Cell proliferation, cell glucose uptake and intracellular oxidative status were investigated. Our results showed that basal placental cell proliferation, glucose uptake, malondialdehyde (MDA) and carbonyl p…
Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status
2016
International audience; All cells are delimited by biological membranes, which are consequently a primary target of stress-induced damage. Cold alters membrane functionality by decreasing lipid fluidity and the activity of membrane proteins. In Saccharomyces cerevisiae, evidence links sphingolipid homeostasis and membrane phospholipid asymmetry to the activity of the Ypk1/2 proteins, the yeast orthologous of the mammalian SGK1-3 kinases. Their regulation is mediated by different protein kinases, including the PDK1 orthologous Pkh1/2p, and requires the function of protein effectors, among them Nce102p, a component of the sphingolipid sensor machinery. Nevertheless, the mechanisms and the act…
Chemical characterization of a variety of cold-pressed gourmet oils available on the Brazilian market
2018
Different specialty extra virgin oils, produced by cold-pressing fruits/nuts (olive, pequi, palm, avocado, coconut, macadamia and Brazil nut) and seeds (grapeseed and canola), and retailed in the Brazilian region of Minas Gerais, were chemically characterized. Specifically, for each type of oil, the fatty acid composition was elucidated by GC-FID, the contents of selected polyphenols and squalene were determined respectively by UHPLC-MS and UHPLC-PDA, whereas minerals were explored by means of ICP-MS. Olive oil was confirmed to have the highest MUFA content due to a valuable level of oleic acid, while oils from grapeseed, Brazil nut and canola were marked by nutritionally important PUFA lev…
Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice
2018
Fibrosis remains a serious health concern in patients with chronic liver disease. We recently reported that chemically induced chronic murine liver injury triggers increased expression of junctional adhesion molecules (JAMs) JAM-B and JAM-C by endothelial cells and de novo synthesis of JAM-C by hepatic stellate cells (HSCs). Here, we demonstrate that biopsies of patients suffering from primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH) display elevated levels of JAM-C on portal fibroblasts (PFs), HSCs, endothelial cells and cholangiocytes, whereas smooth muscle cells expressed JAM-C constitutively. Therefore, localization and function of JA…
Defining sensory descriptors: towards writing rules based on terminology
2007
International audience; Descriptive analysis relies upon the use of sensory descriptors. They are words generally associated to a definition aimed at helping their understanding. However, the writing rules for such definitions remain implicit. The present work is a collaborative attempt from sensory analysts and linguists to get further insight into how definitions are elaborated.Definition formulations were analyzed according to linguistic criteria, syntactic (type and number of nouns, verbs and adjectives) as well as semantic ones (relations of synonymy, metaphor or analogy between the descriptors and their definitions). Such a linguistic analysis was performed on one hundred descriptor d…
Me, Myself and I - Supporting People with Intellectual Disabilities Towards Self-determination
2020
The transition into work is challenging for people with intellectual disabilities (ID) and there are few digital services that support this process. The transition involves several organizations and professionals that need to collaborate and coordinate their documentation and their initiatives. This prototype paper describes a self-reflective career tool designed to support young adults with ID towards self-determination and transitions into work. The users are supported through features such as mapping of interests, skills and abilities, goal setting and progress overview. The prototype of the self-reflective career tool has been evaluated formatively and is continuously redesigned and fur…
“Good translating is very hard work”
2021
Abstract Upon immigrating to New Zealand in 1937, Austrian-born philosopher of science Karl Raimund Popper lived and worked in the English-speaking world, where he published his major works in English. Life events forced him to engage in various forms of self-translation around the same time that he began earnestly working on translating Presocratic philosophical fragments into English. While he rejected language wholesale as an object of philosophical reflection, translation became an exception, a privileged occasion for philosophical reflection on language. This article reads Popper’s thoughts on translation in the context of previously unpublished correspondence between Popper and potent…