Search results for "ocular"

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-an…

2018

Background Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. Objective To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies. Methods PubMed, Medline, Web of Science, Embase databases, and the Cochrane Library were searched up to April 2018 to identify studies that compared primary vitrectomy with and without ILM peeling for RRD with at least six m…

Oxidative stress and its downstream signaling in aging eyes

2014

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,*1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5Uni…

Cadmium, mercury, and lead effects on gill tissue of freshwater crayfishProcambarus clarkii (girard)

1989

Intermolt adult crayfish P. clarkii were used for this work. After acclimatization to laboratory conditions crayfish were exposed to sublethal concentrations of cadmium, mercury, and lead for 96 h. Gills of control and exposed crayfish were removed and ATPase activity and oxygen uptake rate were determined. Structural damage of gill filaments was also observed. Gill tissue respiration rates were measured for individual crayfish using a Gilson differential respirometer. Lead causes a decrease of gill oxygen uptake, but neither cadmium nor mercury seems to affect it at the concentrations employed. Although all metals studied alter gill filament structure, lead damage is the most apparent. In …

Strategies to Reduce Oxidative Stress in Glaucoma Patients

2018

Background Primary open-angle glaucoma (POAG) is a multifactorial pathology involving a variety of pathogenic mechanisms, including oxidative/nitrosative stress. This latter is the consequence of the imbalance between excessive formation and insufficient protection against reactive oxygen/nitrogen species. Objective Our main goal is to gather molecular information to better managing pathologic variants that may determine the individual susceptibility to oxidative/nitrosative stress (OS/NS) and POAG. Method An extensive search of the scientific literature was conducted using PUBMED, the Web of Science, the Cochrane Library, and other references on the topic of POAG and OS/NS from human and a…

DISCOMFORT OCULARE E QUALITA’DELLA VITA NELLA TERAPIA CRONICA ANTIGLAUCOMATOSA: EFFETTO DI UNA SOLUZIONE OFTALMICA MONODOSE

2013

Estudio del desarrollo del macizo craneaofacial y del globo ocular en un modelo de hipotiroidismo congénito-neonatal 2en la rata

2000

RESUMEN Nuestro objetivo es identificar factores que regulen procesos de diferenciación y proliferación celular en el globo ocular y tejidos anexos, cuya alteración estuviera relacionada con la aparición de dismorfogénesis ocular. Basándonos en publicaciones que demuestran que la hormona tiroidea (HT) modula la expresión génica en el cerebro, hemos estudiado si el hipotiroidismo congénito-neonatal (HPCN) inducido experimentalmente en la rata gestante (G) interfiere en el desarrollo embrionario de estructuras del macizo craneofacial y esbozo ocular y particularmente en la ontogénesis de la retina. El HPCN se logró mediante administración ininterrumpida a las ratas en el agua de bebida, desde…

Valutazione tonometrica in due posizioni di sguardo nell'orbitopatia di Graves

2006

Aim.To asses effective role of thickness of superior rectus muscle in the variation of intraocular pression (IOP) in the patients with Graves' ophthalmopathy.Methods.IOP was measured in 76 eyes of 38 patients(mean age,42.4 years;range 19 to 58 years)with Graves' ophthalmopathy in primary and in upgaze position(Elevation with divergence of 23°).Results.IOP in 52 of the 76 eyes was 17.5 +/-2.12 mm Hgin primary position and 21.2 +/-2.75 mm Hg in upgaze position.In the eyes (28)with thickness of the superior rectus muscle >4.6 mm,IOP was 22.7+/-1.48 mm Hg in primary position and 27.1 +/-1.92 mm Hg in upgaze position.The difference in the values in this group is statistically significant ( the p…

Taenia Species, Uterine Branches and Capsule Endoscopy

2018

Hamada et al. show, in their article, several proglottids of an adult stage of a Taenia species in the small bowel of a woman by capsule endoscopy (1). One of the images clearly shows a gravid proglottid that allows the view of the characteristic Taenia uterus morphology, with a central axis and a n

Refraktion, Vorderkammertiefe, Dezentrierung und Tilt nach Implantation monofokaler und multifokaler Silikonlinsen

2001

Hintergrund. Ziel der prospektiven Studie war die Analyse von Refraktion, Vorderkammertiefe, Dezentrierung und Verkippung (Tilt) nach Implantation monofokaler (MONO) und multifokaler (MIOL) Intraokularlinsen (IOL). Patienten und Methode. Bei 103 Augen von 103 Patienten wurde entweder eine dreistuckige monofokale oder multifokale Silikon-IOL implantiert. Vorderkammertiefe (ACD), IOL-Dezentrierung und -Tilt wurden mittels Retroilluminationsfotografie und Scheimpflug-Aufnahmen objektiv quantifiziert. Die Untersuchungen einschlieslich Ermittlung der sujektiven Refraktion wurden praoperativ sowie postoperativ nach 1 Woche und nach 6 Monaten vorgenommen. Ergebnisse. Im Bereich von ±1 dpt um die Z…

Probing a Polar Cluster in the Retinal Binding Pocket of Bacteriorhodopsin by a Chemical Design Approach

2012

Bacteriorhodopsin has a polar cluster of amino acids surrounding the retinal molecule, which is responsible for light harvesting to fuel proton pumping. From our previous studies, we have shown that threonine 90 is the pivotal amino acid in this polar cluster, both functionally and structurally. In an attempt to perform a phenotype rescue, we have chemically designed a retinal analogue molecule to compensate the drastic effects of the T90A mutation in bacteriorhodopsin. This analogue substitutes the methyl group at position C(13) of the retinal hydrocarbon chain by and ethyl group (20-methyl retinal). We have analyzed the effect of reconstituting the wild-type and the T90A mutant apoprotein…