Search results for "ogas"
showing 10 items of 902 documents
Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what …
2019
Albuminuria; Atrasentan; Canagliflozin Albuminuria; Atrasentan; Canagliflozina Albuminúria; Atrasentan; Canagliflozina In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprot…
Effects of an incremental maximal endurance exercise stress-induced cortisol on cognitive performance
2019
Exercise; Cognitive functions; Cortisol Ejercicio físico; Funciones cognitivas; Cortisol Exercici físic; Funcions cognitives; Cortisol Objectives: It can be hypothesized that cognitive performance decreases after fatigue protocol when it coincides with the maximum peak of cortisol. The first aim of this study was to elucidate the effects of a single bout of high intensity exercise on behavioural (i.e., attention and memory) and physiological (i.e., salivary cortisol) responses. The second objective was to evaluate the effect of the performance of the cognitive tasks on cortisol levels. Methods: Thirty-four physically active men (at least 5 days/week of physical activity practice) 38.11 (1.5…
An improvement of ComiR algorithm for microRNA target prediction by exploiting coding region sequences of mRNAs
2020
AbstractMicroRNA are small non-coding RNAs that post-transcriptionally regulate the expression levels of messenger RNAs. MicroRNA regulation activity depends on the recognition of binding sites located on mRNA molecules. ComiR is a web tool realized to predict the targets of a set of microRNAs, starting from their expression profile. ComiR was trained with the information regarding binding sites in the 3’utr region, by using a reliable dataset containing the targets of endogenously expressed microRNA in D. melanogaster S2 cells. This dataset was obtained by comparing the results from two different experimental approaches, i.e., inhibition, and immunoprecipitation of the AGO1 protein--a comp…
Aroniju ogu fitoķīmiskā sastāva izvērtējums
2019
Aroniju ogu fitoķīmiskā sastāva izvērtēšana. Batarāga A. Zinātniskā vadītāja Asoc.prof. Dr. ķīm. Prikšāne A., konsultante Mg.ķīm. Valkovska V. Maģistra darbs, 76 lappuses, 46 attēli, 20 tabulas, 44 literatūras avoti. Latviešu valodā. Darbā analizēts aroniju ogu fitoķīmiskais sastāvs, nosakot kopējo fenolu, flavonoīdu saturu un antiradikālo aktivitāti. Lai pagatavotu analizējamos paraugus, izmantotas gan sasaldētas, gan ţāvētas ogas un kā ekstrahenti – 70 % etanola/ūdens, 10 % glicerīna/etanola un daţādu koncentrāciju un pH vērtību etanola/ūdens/HCl maisījumi. Pēc ultraskaľas veicinātas ekstrakcijas un 1 – 3 nedēļu ilgas macerācijastika noteikts kopējo fenolu saturs, izmantojot FolinCiocalte…
Augļu mušas Drosophila melanogaster tēviņu agresīvās uzvedības saistība ar rauga daudzumu barībā
2022
Agresija ir svarīgs evolūcijas virzītājspēks. Dzīvnieki, kuri būs spējīgāki uzvarēt konfliktus varēs ar lielāku varbūtību nodot savus gēnus nākošajām paaudzēm. Tomēr kādi faktori ietekmē dzīvnieka varbūtību uzvarēt nav līdz galam noskaidrots. Teorētiskie modeļi un esošie pētījumi sniedz tikai virspusēju skatījumu. Dzīvnieki savas dzīves laikā būs pakļauti dažādiem vides faktoriem ar variējošu pakāpi, tomēr, ne visi būs vienlīdz nozīmīgi agresīvas uzvedības mainībā. Uzturs dzīvniekiem mainās dzīves laikā un attīstības sākumā optimālā barības vielu attiecība būs svarīga indivīda nākotnes izdzīvošanā un ģenētiskajā fitnesā, jo fiziskais fenotips visam mūžam veidojas tieši individuālās attīstīb…
Landfill gas upgrading with pilot-scale water scrubber: Performance assessment with absorption water recycling
2012
Abstract A pilot-scale counter current absorption process for upgrading municipal solid waste (MSW) landfill gas to produce vehicle fuel was studied using absorption, desorption and drying units and water as an absorbent. Continuous water recycling was used without adding new water to the system. The process parameters were defined by a previous study made with this pilot system. The effect of pressure (20–25 bar), temperature (10–25 °C) and water flow speed (5.5–11 l/min) on the upgrading performance, trace compounds (siloxanes, halogenated compounds) and water quality were investigated. Raw landfill gas flow was kept constant at 7.41 Nm3/h. Methane (CH4) and carbon dioxide (CO2) contents …
Complete genome sequence of the strain Defluviitoga tunisiensis L3, isolated from a thermophilic, production-scale biogas plant.
2015
An anaerobic, thermophilic bacterium belonging to the phylum Thermotogae was isolated from a rural, thermophilic biogas plant (54 degrees C) producing methane-rich biogas from maize silage, barley, cattle and pig manure. Here we report the first complete genome sequence of the Defluviitoga tunisiensis strain L3, an isolate from the family Thermotogaceae. The strain L3 encodes several genes predicted to be involved in utilization of a large diversity of complex carbohydrates including cellobiose and xylan for the production of acetate, hydrogen (H-2) and carbon dioxide (CO2). The genome sequence of D. tunisiensis L3 provides the basis for biotechnological exploitation of genetic determinants…
Prostitución y tratas de blancas
2003
Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI.
2010
The evolutionarily conserved ATP-dependent nucleosome remodelling factor ISWI can space nucleosomes affecting a variety of nuclear processes. In Drosophila, loss of ISWI leads to global transcriptional defects and to dramatic alterations in higher-order chromatin structure, especially on the male X chromosome. In order to understand if chromatin condensation and gene expression defects, observed in ISWI mutants, are directly correlated with ISWI nucleosome spacing activity, we conducted a genome-wide survey of ISWI binding and nucleosome positioning in wild-type and ISWI mutant chromatin. Our analysis revealed that ISWI binds both genic and intergenic regions. Remarkably, we found that ISWI…
NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination
2020
Abstract Methods for the detection of m6A by RNA-Seq technologies are increasingly sought after. We here present NOseq, a method to detect m6A residues in defined amplicons by virtue of their resistance to chemical deamination, effected by nitrous acid. Partial deamination in NOseq affects all exocyclic amino groups present in nucleobases and thus also changes sequence information. The method uses a mapping algorithm specifically adapted to the sequence degeneration caused by deamination events. Thus, m6A sites with partial modification levels of ∼50% were detected in defined amplicons, and this threshold can be lowered to ∼10% by combination with m6A immunoprecipitation. NOseq faithfully d…