Search results for "orzo"
showing 10 items of 64 documents
El viaje desde los cuestionarios Likert a los cuestionarios de elección forzosa: evidencia de la invarianza de los parámetros de los ítems
2019
Multidimensional forced-choice questionnaires are widely regarded in the personnel selection literature for their ability to control response biases. Recently developed IRT models usually rely on the assumption that item parameters remain invariant when they are paired in forced-choice blocks, without giving it much consideration. This study aims to test this assumption empirically on the MUPP-2PL model, comparing the parameter estimates of the forced-choice format to their graded-scale equivalent on a Big Five personality instrument. The assumption was found to hold reasonably well, especially for the discrimination parameters. In the cases in which it was violated, we briefly discuss the …
Innovative Glaukomtherapie
2001
Lokale Karboanhydrasehemmer wurden mit Dorzolamid 1995 in die medikamentose Glaukomtherapie eingefuhrt. Im Jahr 2000 wurde nun ein zweiter topischer Karboanhydrasehemmer auf dem deutschen Markt eingefuhrt: Brinzolamid. Die augeninnendrucksenkende Wirkung beider Medikamente ist vergleichbar bei einem etwas unterschiedlichen Nebenwirkungsprofil. Die Breitenanwendung von Dorzolamid zeigt ein positives Nutzen/Risiko-Verhaltnis. Eine Kombinationstherapie mit lokalen Karboanhydrasehemmern bewirkt zusatzlich zu allen anderen topischen Glaukommedikamenten eine weitere Drucksenkung. Zudem liegen im Tierversuch erste Hinweise vor, dass Dorzolamid druckunabhangig die Durchblutungssituation am hinteren…
Update on topical carbonic anhydrase inhibitors
2001
Topical carbonic anhydrase inhibitors are a novel addition to the armamentarium of medical glaucoma treatment; dorzolamide has been available since 1995 and brinzolamide since 1998. They lower intraocular pressure by inhibiting carbonic anhydrase, a key enzyme for aqueous humor formation. Intraocular pressure-lowering activity of the substances appears to be the same and is similar to that of most other agents, but it does not reach the activity of the unselective beta-blocker timolol or the prostaglandin latanoprost. On concomitant treatment, additivity is reached with all other topical agents. A possible improvement of blood flow may offer an additional benefit, but its significance for t…
Intercurrent factors associated with the development of open-angle glaucoma in The European Glaucoma Prevention Study
2007
Purpose: To evaluate the intercurrent factors for the development of open-angle glaucoma (OAG) in ocular hypertensive patients who were enrolled in the European Glaucoma Prevention Study (EGPS). Design: Randomized, double masked, controlled clinical trial. Methods: setting: Multicenter. study population: A total of 1,077 patients fulfilled a series of inclusion criteria, including intraocular pressure (IOP) 22 to 29 mm Hg, normal and reliable visual fields (VFs) and normal optic disks. intervention: Treatment with dorzolamide or placebo. main outcome measures: Glaucoma-related VF or optic disk changes. Clinical data were collected every six months during a five-year follow-up. Proportional …
La extinción del contrato de trabajo en la reforma laboral de 2012
2013
Una de las instituciones claves en todo sistema de relaciones laborales es, sin lugar a dudas, la extinción del contrato de trabajo. Ese carácter fundamental seguramente explique que su regulación sea objeto de una continua atención en diversos planos, no solo en el normativo, sino también en el político y en el doctrinal. La reforma laboral de 2012 ha afectado de manera notable a la materia extintiva. Pues bien, el objeto de este trabajo se dirige a dar cuenta de algunos de estos cambios: de entrada, se analizan los producidos en el plano causal y procedimental, lo que remite al análisis de la reforma en los arts. 51 y 52 ET; a continuación se abordan los cambios en el régimen de efectos, …
Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolam…
2017
Introduction To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients. Materials and methods Sixty-two eyes undergoing trabeculectomy with mitomycin C were included in this monocentric prospective randomized controlled study. IOP change between baseline and 3 months post-op was defined as the primary efficacy variable. Secondary efficacy variables included the number of 5-fluorouracil (5-FU) injections, needlings, suture lyses, preoperative IOP change, hyperten…
Efficacy and tolerability of preservative-free eye drops containing a fixed combination of dorzolamide and timolol in glaucoma patients.
2010
To evaluate the efficacy and tolerability of preservative-free eye drops (dorzolamide/timolol) in routine management of preservative-sensitive glaucoma patients.Data from 2,298 glaucoma patients requiring intraocular pressure (IOP) reduction and suffering from intolerance to benzalkonium chloride or active agents of previously used eye drops were valid for baseline and safety analysis in this prospective, open, noncomparative, multicenter, noninterventional study. Patients were treated with preservative-free dorzolamide/timolol eye drops for 12 weeks. Main efficacy endpoint was IOP reduction after 12 weeks of treatment. Two thousand forty-nine patients were considered for efficacy analysis.…
Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.
2008
This paper reports cytotoxic effects and changes in the P450 system after exposing rat hepatocytes to four polyphenol-rich products widely used in Cuban traditional medicine (Mangifera indica L. (MSBE), Thalassia testudinum (Tt), Erythroxylum minutifolium and confusum extracts). Effects of mangiferin, the main polyphenol in MSBE, were also evaluated. Cytotoxicity was assayed by the MTT test after exposure of cells to the products (50-1000 microg/mL) for 24 or 72 h. The results showed that 500 microg/mL MSBE was moderately cytotoxic after 72 h, while mangiferin was not. Marked reductions in cell viability were produced by Erythroxylum extracts at concentrationsor = 200 microg/mL, whereas onl…
Le varietà migliori per l’orzo da birra
2016
Il 2016, come già il 2015, è stato un anno assai variegato per le produzioni, ma certamente più favorevole per la coltura dell’orzo primaverile al Centro-Nord rispetto al biennio 2013-2014
CHARACTERIZATION OF RUBBERIZED ASPHALT FOR RAILWAY SUB-BALLASTS
Tesi di dottorato sotto la supervisione del professore Gaetano di Mino del Dipartimento di Ingegneria Civile di Palermo), come borsista Marie-Curie all'interno del progetto SUPRITN 2013/2017. Il mio lavoro e la linea della ricerca riguarda i conglomerati bituminosi con granulato di gomma per lo strato di sub-ballast nelle linee ferroviarie. L’attività di ricerca comprende il mix-design dell’asfalto con aggiunta di gomma, la caratterizzazione e le prestazioni per la ferrovia in termini di comportamento meccanico e lo smorzamento delle vibrazioni. In particolare con l’avvento dell’alta velocità, diversi studi hanno evidenziato ottime caratteristiche fisico-meccaniche per ciò che riguarda il c…