Search results for "ostas"

Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings

2013

[EN] Copper is an essential micronutrient in higher plants, but it is toxic in excess. The fine adjustments required to fit copper nutritional demands for optimal growth are illustrated by the diverse, severe symptoms resulting from copper deficiency and excess. Here, a differential transcriptomic analysis was done between Arabidopsis thaliana plants suffering from mild copper deficiency and those with a slight copper excess. The effects on the genes encoding cuproproteins or copper homeostasis factors were included in a CuAt database, which was organised to collect additional information and connections to other databases. The categories overrepresented under copper deficiency and copper e…

Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis

2011

Mutant strain of the facultatively anaerobic, ethanol-producing bacteriumZymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide.

Role of Hsp70 in Multiple Sclerosis: An Overview

2019

For many years heat shock protein 70 (Hsp70) was considered exclusively an intracellular chaperone contributing to protein proteostasis and in apoptotic pathway block. Lately it has been demonstrated that Hsp70 is actively released in the extracellular environment, thereby promoting the activation of the immune system by stimulating innate and adaptive responses through the activation of APCs. Its expression in the nervous system is induced in a variety of pathological conditions. Emerging evidences displayed that Hsp70 is a critical regulator in normal neural cells. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) directed against myelin antigens. In thi…

Isolation of T Cells from the Skin

2014

T cells can be found in skin under steady-state conditions as well as in inflammatory processes. T cells in skin play an important role in immune homeostasis as well as control of infectious, inflammatory diseases or tumors. In addition, several important and frequent skin diseases such as psoriasis, atopic dermatitis, autoimmune disease, and contact allergy are initiated by T cells. In skin diseases, the majority of antigen-specific T cells can be found in the tissue, not the peripheral blood. Here, we present a protocol suitable for isolation of skin-resident (inflammatory) T cells that can be used for an in-depth characterization of their frequency, function, and role for the respective …

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

2013

Signalling by the cytokine TGF-β regulates mature CD4+ T cell populations but is not involved in the survival and function of regulatory T cells.

Sprint and Strength Training Modulates Autophagy and Proteostasis in Aging Sprinters

2020

Purpose Exercise and aging may modulate muscle protein homeostasis and autophagy, but few studies examine highly-trained middle-aged or older individuals. This study elucidated the effects of a new long-term training stimulus on markers of muscle autophagy and unfolded protein response (UPR) and on sprint running performance in masters sprinters. Methods Thirty-two male competitive sprinters (aged 40–76 years) were randomly divided into experimental (EX) and control (CTRL) groups. The EX training program was a combination of heavy and explosive strength and sprint exercises aimed at improving sprint performance. Fifteen and thirteen participants completed the 20-week intervention period in …

Latvijas aviācijas vēsture: bibliogrāfija (1911-1996)

1997

2020

BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their turnover via the two major protein degradation pathways, i.e. proteasomal degradation and macroautophagy. On the one hand, BAG3 competes with BAG1 for binding to HSP70, thereby preventing the proteasomal degradation of its client proteins. By functionally interacting with HSP70 and LC3, BAG3 also delivers polyubiquitinated proteins to the autophagy pathway. BAG3 exerts a numbe…

Ko atklāj Ķīnas Ceļa un jostas iniciatīvas investīcijas? Nestriktas kopas kvalitatīvā salīdzinošā analīze

2020

Maģistra darbā “Ko atklāj Ķīnas Ceļa un jostas iniciatīvas investīcijas? Nestriktas kopas kvalitatīvā salīdzinošā analīze” tika analizēts Ķīnas Ceļa un jostas iniciatīvas (BRI) investīciju daudzums 78. Eirāzijas valstīs, lai noteiktu, kādi valstis raksturojoši faktori vai apstākļi ietekmē to vēlmi pievienoties BRI. Izvēlētajām valstīm pēc detalizētas pētnieciskās literatūras analīzes tika noteikti astoņi investīcijas veicinošie faktori (gan politiskie, gan ekonomiskie). Izvēlētie faktori tika pretnostatīti Ķīnas BRI investīciju apjomam uz vienu iedzīvotāju konkrētā valstī, lai varētu secināt, kādi valsti raksturojoši apstākļi un priekšnoteikumi veicina Ķīnas BRI investīciju plūsmu uz konkrē…

Peter Schmidt, Ostasienwissenschaftler, Linguist und Folklorist: eine vorläufige Biographie

1982

Publikācija par latviešu sinologu, valodnieku, etnogrāfu un folkloristu Pēteri Šmitu ietver Hartmuta Valravensa ievadtekstu, Haralda Biezā uzrakstīto biogrāfisko apcerējumu, dzīves datu, pedagoģiskās darbības un ceļojumu hronoloģiju, profesora Pētera Šmita darbu bibliogrāfiju, literatūru par viņu, personīgo saraksti un Latvijas Universitātes profesora Pētera Šmita grāmatu kolekciju Latvijas Universitātes Bibliotēkā.