6533b838fe1ef96bd12a46db
RESEARCH PRODUCT
Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis
Nina GalininaReinis RutkisInese StrazdinaZane LasaUldis Kalneniekssubject
Article Subjectlcsh:MedicineBiologyZymomonas mobilislcsh:TechnologyGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundOxygen ConsumptionSpecies SpecificityHomeostasisHydrogen peroxidelcsh:ScienceGeneral Environmental ScienceAlcohol dehydrogenaseZymomonaslcsh:Tlcsh:RAlcohol DehydrogenaseHydrogen PeroxideGeneral Medicinebiology.organism_classificationOxygenBiochemistrychemistryCatalasebiology.proteinlcsh:QNAD+ kinaseOxidation-ReductionAnaerobic exerciseNADPHomeostasisIntracellularResearch Articledescription
Mutant strain of the facultatively anaerobic, ethanol-producing bacteriumZymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-10-17 | The Scientific World Journal |