Search results for "oxidative stress."

Evaluation of carbamazepine uptake and metabolization by Typha spp., a plant with potential use in phytotreatment

2011

Abstract Phytoremediation technologies such as constructed wetlands have shown higher efficiencies in removal of pharmaceuticals from wastewaters than conventional wastewater treatment processes, and plants seem to have an important role in the removal of some of those compounds. In this context, a study was conducted to assess tolerance, uptake, and metabolism of the epilepsy drug, carbamazepine, by the macrophyte Typha spp. This evaluation was conducted in hydroponic solutions with 0.5–2.0 mg/L of this pharmaceutical for a maximum period of 21 days. The removal of carbamazepine from nutrient solutions by the plants reached values of 82% of the initial contents. Furthermore, a metabolite (…

Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation o…

2004

Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA. The plasma membrane of the sperm cell, which has high levels of polyunsaturated fatty acids, renders it particularly sensitive to free radical–mediated attacks. The freezing and subsequent thawing of sperm is a physically stressful process carried out during routine procedures in assisted reproduction techniques, which results in a highly variable and unpredictable reduction in the number of motile sperm cells. Subsequently, oxidative status can positively or negatively affect the motility, viability, and fertilizing capacity of thawed…

The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activit…

2022

The Phosphohistone H3 (PHH3) antibody is recognized as a biomarker of cell proliferation, specific for cells in mitosis, of prognostic value in different malignant neoplasms, however it has been poorly studied in oral squamous cell carcinoma (OSCC). The main objective of this study was to evaluate the immunoexpression of the PHH3 in the OSCC, through the correlation with the immunoexpression of Ki-67, the mitotic activity index (MAI), histological grading, clinical-morphological parameters and the rate of survival. The study sample consisted of 62 cases of OSCC diagnosed in the Pathological Anatomy Laboratory of the Faculty of Dentistry, University of the Republic (Uruguay). In each of them…

Cell clones more resistant to oxidative stress selecte from embryonic and adult mesoangioblast stem cell population.

2012

Differentiation capability of clones of mouse mesoangioblast stem cells resistant to oxidative stress.

2013

Disulfide stress as a novel type of oxidative stress in acute inflammation

2012

SP404OXIDATIVE STRESS AND CHRONIC KIDNEY DISEASE: TRAVELLING COMPANIONS

2019

Role of beta3-adrenergic receptors in intestinal diseases

2022

The Inflammatory Bowel Diseases (IBD), characterized by a gastro-intestinal tract inflammation, are a global health-care problem due to their morbidity, mortality and the constant increase in their worldwide incidence. The available therapies are still not curative only providing temporary symptomatic relief and reduction in complications.Although etiology is still unclear, IBD results in an interplay of various factors among which impaired and/or inappropriate immune response toward intestinal bacteria. Increasing disease incidence link environmental triggers occurring during socioeconomic development to IBD, especially stress. In this work, we aimed to investigated the role of adrenergic …

Incidences de l’ischémie cérébrale sur la fonction et la sensibilité cardiaques à l’ischémie

2019

For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function.The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo, and how they influence cardiac vulnerability to ischemia-reperfusion injury and the expression of cardiac genes and proteins involved in cardioprotective pathways.Thus, in our work, we studied cardiac function in a rat stroke model induced by cerebral embolization.The main results show that experimental stroke 1/ impaired …

Inactivation of the ftsH gene of Lactobacillus plantarum WCFS1: Effects on growth, stress tolerance, cell surface properties and biofilm formation

2012

FtsH proteins are ubiquitous membrane-bound, ATP-dependent metalloproteases of the AAA family. In eubacteria, FtsH is involved in protein quality control under stress conditions. Lactobacillus plantarum is a widespread lactic acid bacterium that is encountered in several fermented food, including dairy products, vegetables and meat. In the present work the expression of the ftsH gene of L. plantarum was studied by quantitative real time RT-PCR in bacterial cultures subjected to various abiotic stresses. Both oxidative stress and addition of a membrane-fluidizing agent induced ftsH transcription, while a depletion of carbon-source repressed its mRNA level. Mutants deprived of the FtsH protea…