Search results for "path"

Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity.

2022

Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.

The (im)possible success of disadvantaged students. Reflections on education, migration and social change

2019

The paper focuses on the ?unexpected pathways? of successful students with an immigrant background: these biographical routes, that seems socially impossible, raise theoretical issues around the individual-society, actor-structure relationship. Disadvantaged students who succeed represent a sociological challenge in the attempt to understand atypical situations and to identify the institutional processes and the structural opportunities that facilitate them, reducing ethnic inequalities in education. This framework is the starting point of the Su.Per. project (Success in educational pathways of students with immigrant background), based on the collection of written autobiographies of 65 imm…

À la recherche de l’intelligence : de la mesure et de l’organisation

2016

Cet ouvrage aborde le champ des difficultés et des troubles de la vie intellectuelle et cognitive dans l’enfance et, plus généralement, celui des apprentissages et des moyens psychiques d’accès à la connaissance impliqués dans la réussite scolaire en particulier, et dans la réussite plus globale de l’enfant dans sa vie d’enfant, son bien-être, son développement harmonieux et dans sa future vie d’adulte.Fondé sur l’expérience clinique des auteurs auprès des enfants et des adolescents, mais aussi sur un enseignement dans le cadre d’un Diplôme universitaire, ce livre apporte également un éclairage plus large sur les processus impliqués dans les activités d’apprendre, de connaître et de penser,…

Toll Like Receptors as Sensors of the Tumor Microbial Dysbiosis: Implications in Cancer Progression

2021

Microbiota is a complex ecosystem of active microorganisms resident in the body of mammals. Although the majority of these microorganisms resides at the distal gastrointestinal tract, high-throughput DNA sequencing technology have made possible to understand that several other tissues of the human body host their own microbiota, even those once considered sterile, such as lung tissue. These bacterial communities have important functions in maintaining a healthy body state and the host immune system has evolved multiple mechanisms by which maintaining a symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and r…

Pedagogìčna vzaêmodìâ âk važlivij činnik udoskonalennâ fahovoï pìdgotovki majbutnìh učitelìv

2017

In the article the problem of empathy is examined as the social-psychological phenomenon, the historical aspects of establishment of this concept are selected. It is here underlined going near understanding of this concept and role of empathy for the future teachers.

Decency and Empathy: The Perspective of Interdisciplinarity - from Phenomenological Hermeneutics to the Academic Library

2019

Using Temporal Expectation to Assess Auditory Streaming in Mice

2018

Auditory streaming is the process by which environmental sound is segregated into discrete perceptual objects. The auditory system has a remarkable capability in this regard as revealed in psychophysical experiments in humans and other primates. However, little is known about the underlying neuronal mechanisms, in part because of the lack of suitable behavioural paradigms in non-primate species. The mouse is an increasingly popular model for studying the neural mechanisms of perception and action because of the range of molecular tools enabling precise manipulation of neural circuitry. Here we present a novel behavioural task that can be used to assess perceptual aspects of auditory streami…

Identification of omic profiles for diagnosis and monitoring of bladder cancer

2019

La presente Tesis titulada Identificación de perfiles ómicos para el diagnóstico y la monitorización del cáncer de vejiga se centra en la identificación de biomarcadores metabolómicos urinarios no invasivos para el diagnóstico y la monitorización del cáncer de vejiga (CaV). Con este fin, se han utilizado dos plataformas analíticas: la Resonancia Magnética Nuclear (Nuclear Magnetic Resonance, 1H NMR) y la Cromatografía Líquida de alta resolución acoplada a la Espectrometría de Masas (Ultraperformance Liquid Chromatography–Mass Spectrometry, UPLC-MS). Además, se han analizado tejidos vesicales mediante la técnica de Resonancia Magnética Nuclear de Alta Resolución con Giro de Ángulo Mágico (Hi…

The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

2019

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…

Le médicament homéopathique dans l'histoire du médicament, Co construction, confrontation, coopération. Histoire, Transmission, Représentation

2007

The dynamics of this thesis resides in the search for the breach between the historical positioning (in relation to scientific fact itself) of homeopathic medication in the history of medical sciences, and the representation made of it in the past and present. By distinguishing what may be at stake, we are led to identify the positioning and impact of the mode of transmitting scientific fact as lacking a historical link to the history of medical sciences, notably medication. Our research hypothesis thus postulates that the transmission mode is at the source of discrepancies in representation. The links between context breakthroughs, such as the role of influences, are just parameters that, …