Search results for "patho"

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

2020

AbstractObesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the exact mechanisms remain incompletely understood. Here we demonstrate that macrophage scavenger receptor 1 (MSR1, CD204) expression is associated with the occurrence of hepatic lipid-laden foamy macrophages and correlates with the degree of steatosis and steatohepatitis in a cohort of 170 NAFLD patients. Mice lacking Msr1 are protected against high fat-cholesterol diet (HFD)-induced metabolic disorder, showing fewer hepatic lipid-laden foamy macrophages, less hepatic inflammation, improved dyslipidemia and glucose tolerance, while showing a change in hepatic …

Oral paracoccidioidomycosis in a non-endemic region from Brazil: A short case series.

2019

Background Although the paracoccidioidomycosis (PCM) is endemic in Brazil, the occurrence in most states from the North and Northeastern Brazil is very unusual. The aim of this study was to evaluate the clinicopathologic features of a case series of oral PCM in a non-endemic region from Brazil (Northeastern region), discussing the clinical and histopathological differential diagnoses of the oral manifestations of the disease. Material and methods Between 2000 and 2017, all cases of oral PCM were retrieved from the Oral Pathology Laboratory, Universidade Federal de Pernambuco, located at Northeastern Brazil. Clinical data, such as age, gender, origin, occupation, site, symptoms, time of comp…

Normal values for fundus perimetry with the MAIA microperimeter and short-term repeatability evaluation

2016

National audience; Purpose To assess retinal sensitivity by means of microperimetry and to evaluate the intersession fluctuation using the MAIA microperimeter in healthy volunteers. Methods Prospective, monocentre study. Fifty‐six healthy volunteers (age range, 20–80 years), underwent an automatic, full‐threshold microperimetry of the central field (custom grid, area of 10° in diameter, 37 stimulated points), with the MAIA microperimeter (CenterVue, Padova, Italy). A subgroup of 24 subjects was retested after 1 h (test 2) and 1 week (test 3) to determine the repeatability of the technique. A subgroup of 22 subjects was also tested on the OPKO microperimeter (Optos, Dunfermline, Scotland) (a…

1H, 13C, and 15N NMR chemical shift assignment of the complex formed by the first EPEC EspF repeat and N-WASP GTPase binding domain

2021

AbstractLEE-encoded effector EspF (EspF) is an effector protein part of enteropathogenic Escherichia coli’s (EPEC’s) arsenal for intestinal infection. This intrinsically disordered protein contains three highly conserved repeats which together compose over half of the protein’s complete amino acid sequence. EPEC uses EspF to hijack host proteins in order to promote infection. In the attack EspF is translocated, together with other effector proteins, to host cell via type III secretion system. Inside host EspF stimulates actin polymerization by interacting with Neural Wiskott-Aldrich syndrome protein (N-WASP), a regulator in actin polymerization machinery. It is presumed that EspF acts by di…

The cholinergic system in Down's syndrome

2006

The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain. Alterations of the transmission communicators are accompanied by reduction of the cortical activity, which is associated with a learning and memory deficit. Down's syndrome is a pathological condition characterized by a high number of abnormalities that involve the brain.The cholinergic system is involved in alterations of the neurological system such as severe learning difficulties.To explain these alterations, important results are obtained from studies about murine trisomy 16 (animal model of Down's syndrome).The results obtained provide useful elements in the improvement of knowledge ab…

Una aproximación al valor social subjetivo de la educación en Iberoamérica: Evidencias de validez entre Argentina, España y República Dominicana

2017

espanolSe presenta un estudio de validacion sobre el valor social subjetivo de la educacion entre Argentina, Espana y Republica Dominicana. Se trata de una investigacion de metodologia mixta desarrollada con 251 docentes a traves de encuesta online y grupos focales. Se analiza y valora el constructo teorico de acuerdo a su relevancia y susceptibilidad de cambio a traves de una validacion cruzada entre tres contextos. Los resultados muestran un acuerdo estadisticamente significativo en cada pais, ademas de que aparecen diferencias significativas entre ellos. El concepto trabajado es fundamental a nivel internacional, ya que supone una reflexion hacia la potencialidad de la propia educacion. …

Improving Speaker-Independent Lipreading with Domain-Adversarial Training

2017

We present a Lipreading system, i.e. a speech recognition system using only visual features, which uses domain-adversarial training for speaker independence. Domain-adversarial training is integrated into the optimization of a lipreader based on a stack of feedforward and LSTM (Long Short-Term Memory) recurrent neural networks, yielding an end-to-end trainable system which only requires a very small number of frames of untranscribed target data to substantially improve the recognition accuracy on the target speaker. On pairs of different source and target speakers, we achieve a relative accuracy improvement of around 40% with only 15 to 20 seconds of untranscribed target speech data. On mul…

Deep Neural Network Frontend for Continuous EMG-Based Speech Recognition

2016

Early intentional communication as a predictor of language development in young toddlers

1999

Interrelations between various types of early intentional communi cation measures, and their relations to children's concurrent and subsequent language skills and maternal interactional sensitivity were studied in a sample of 111 mother-infant pairs. Intentional communication was assessed at 14 months of age using a composite of early actions and gestures derived from parental reports (MacArthur Communicative Development Inventories, MCDI), and measures of early joint attentional behaviours obtained via observations of parent-child play interaction. The sum of actions and gestures and the measures of joint attentional behaviours correlated significantly with each other suggesting that the …

Diachronic development of gender in city names in Spanish

2019

AbstractThis paper examines the gender assignment rules that apply to city names in the history of Spanish, relying for the first time on extensive corpus-based material. The empirical data show that gender assignment changed from a referential principle that consistently assigned city names to the feminine (due to the feminine basic level noun for ‘city’) to a phonologically driven assignment rule, with city names ending in-agenerally being assigned to the feminine (e.g.Barcelona) and those ending in-oor-C to the masculine (e.g.Toledo,Madrid). However, the overall picture is much more complicated than previously suggested in the literature since there is still a high degree of gender varia…