Search results for "phosphate"
showing 10 items of 1874 documents
Correlation study of GAPDH, Bcl-2, and Bax protein immunoexpression in patients with colorectal adenocarcinoma.
2018
Introduction Colorectal cancer (CRC) is the third and second most commonly diagnosed cancer worldwide in males and females, respectively. Despite prominent progress in diagnosis and treatment, the recurrence rates are still high. A tumour hypoxic environment leads to an increase in glycolytic metabolism. The crucial intermediate component of glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), could play a significant role in cancer progression. An increased level of GAPDH has been described in oncogene-induced transformation and anti-apoptotic function. In other studies, GAPDH has been involved in apoptosis induction. Aim We examined colorectal adenocarcinoma samples to assess the…
Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study.
2015
Summary Background Molybdenum cofactor deficiency (MoCD) is characterised by early, rapidly progressive postnatal encephalopathy and intractable seizures, leading to severe disability and early death. Previous treatment attempts have been unsuccessful. After a pioneering single treatment we now report the outcome of the complete first cohort of patients receiving substitution treatment with cyclic pyranopterin monophosphate (cPMP), a biosynthetic precursor of the cofactor. Methods In this observational prospective cohort study, newborn babies with clinical and biochemical evidence of MoCD were admitted to a compassionate-use programme at the request of their treating physicians. Intravenous…
Proton conducting polymer composites for electrochromic devices
1999
Abstract This report describes composite proton electrolytes composed of nanosize zirconium phosphate or antimonic acid particles suspended in a poly(vinyl acetate)/glycerin gel matrix. The proton conductivity was 10 −3 –10 −4 S/cm at room temperature, thermal stability prevailed up to at least 110°C, and compatibility was found with oxide electrodes; these properties makes the electrolyte suitable for use in solid state electrochemical devices. The temperature dependence of the conductivity was found to obey the Williams-Landel-Ferry relationship at temperatures over 60°C, thus suggesting that the ion conductivity in the composite electrolyte can be described by mechanisms normally taken t…
Efficient, Cyanine Dye Based Bilayer Solar Cells
2012
Simple bilayer solar cells, using commercially available cationic cyanine dyes as donors and evaporated C60 layer as an acceptor are prepared. Cyanine dyes with absorption maxima of 578, 615 and 697 nm having either perchlorate or hexafluorophosphate counter-ions are evaluated. The perchlorate dye leads to cells with S-shape current-voltage curves; only the dyes with the hexafluorophosphate counter-ions lead to efficient solar cells. When the wide bandgap dyes are employed, S-shape current-voltage curves are obtained when the conductive polymer PEDOT:PSS is used as hole transport layer. Substitution of PEDOT:PSS with MoO3 leads to cells with more rectangular current–voltage curves and high …
Evaluation of horizontal ridge augmentation using beta tricalcium phosphate and demineralized bone matrix: A comparative study
2013
Objectives: To evaluate the effectiveness of beta tricalcium phosphate (Beta-TCP) alone compared to Beta-TCP and Demineralized Bone Matrix (DBM) in regenerating localized horizontal maxillary alveolar ridge deficiencies prior to implant placement. Study Design: The study included 20 patients with horizontal maxillary ridge deficiencies limited to one or more neighbouring teeth and initial ridge width of . 5mmm. Patients were divided equally into two equal groups. Ridge augmentation was performed using Guided Bone Regeneration (GBR) principals. In group I GBR was performed using Beta-TCP only, while in group II both Beta-TCP and DBM were used. Following a 6 months healing period, bone cores …
What monomeric nucleotide binding domains can teach us about dimeric ABC proteins
2020
The classic conceptualization of ATP binding cassette (ABC) transporter function is an ATP-dependent conformational change coupled to transport of a substrate across a biological membrane via the transmembrane domains (TMDs). The binding of two ATP molecules within the transporter's two nucleotide binding domains (NBDs) induces their dimerization. Despite retaining the ability to bind nucleotides, isolated NBDs frequently fail to dimerize. ABC proteins without a TMD, for example ABCE and ABCF, have NBDs tethered via elaborate linkers, further supporting that NBD dimerization does not readily occur for isolated NBDs. Intriguingly, even in full-length transporters, the NBD-dimerized, outward-…
The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle
2015
12 páginas, 4 figuras, 2 tablas.
Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.
2013
ATP regulates the function of many proteins in the cell by transducing its binding and hydrolysis energies into protein conformational changes by mechanisms which are challenging to identify at the atomic scale. Based on molecular dynamics (MD) simulations, a method is proposed to analyze the structural changes induced by ATP binding to a protein by computing the effective free-energy landscape (FEL) of a subset of its coordinates along its amino-acid sequence. The method is applied to characterize the mechanism by which the binding of ATP to the nucleotide-binding domain (NBD) of Hsp70 propagates a signal to its substrate-binding domain (SBD). Unbiased MD simulations were performed for Hsp…
P-recovery in a pilot-scale struvite crystallisation reactor for source separated urine systems using seawater and magnesium chloride as magnesium so…
2019
[EN] Practical recovery of a non-renewable nutrient, such as phosphorus (P), is essential to support modern agriculture in the near future. The high P content of urine, makes it an attractive source for practicing the recovery of this crucial nutrient. This paper presents the experimental results at pilot-plant scale of struvite crystallisation from a source-separated urine stream using two different magnesium sources, namely magnesium chloride and seawater. The latter was chosen as sustainable option to perform P-recovery in coastal areas. Real seawater was used to assess in a more realistic way its efficiency to precipitate P as struvite, since its composition (with noticeable concentrati…
Ecological restoration in contaminated soils of Kokdzhon phosphate mining area (Zhambyl region, Kazakhstan)
2016
Abstract This study provides results of an ecological restoration activity performed in the Kokdzhon phosphate mining of the Zhambyl region (a semi-desert mining area of Kazakhstan). The test area was made by a quarry-hole, about 1.25 hectares wide, that was preliminarily filled with the earthy material of a dump and, subsequently, levelled. The total volume of human transported material (HTM) used was 700 tonnes. Soil samples were taken from 0 to 30 cm depth at 23 sampling sites and several soil quality parameters were determined. In the test area 750 tree species were planted in suitable dug holes: (150 seedlings of Russian Olive; 150 seedlings of Black Saxaul); 150 seedlings of Androsov …