Search results for "pig"
showing 10 items of 2235 documents
COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN…
2016
Allantoin is traditionally employed in the treatment of skin ulcers and hypertrophic scars. In the present work, to improve its local deposition in the skin and deeper tissues, allantoin was incorporated in conventional liposomes and in new argan oil enriched liposomes. In both cases, obtained vesicles were unilamellar, as confirmed by cryo-TEM observation, but the addition of argan oil allowed a slight increase of the mean diameter (∼130nm versus ∼85nm). The formulations, especially those containing argan oil, favoured the allantoin accumulation in the skin, in particular in the dermis (∼8.7μg/cm(2)), and its permeation through the skin (∼33μg/cm(2)). The performances of vesicles as skin d…
Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
2021
The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…
A computational method for studying the relation between alternative splicing and DNA methylation.
2015
Alternative splicing is an important mechanism in eukaryotes that expands the transcriptome and proteome significantly. It plays an important role in a number of biological processes. Understanding its regulation is hence an important challenge. Recently, increasing evidence has been collected that supports an involvement of intragenic DNA methylation in the regulation of alternative splicing. The exact mechanisms of regulation, however, are largely unknown, and speculated to be complex: different methylation profiles might exist, each of which could be associated with a different regulation mechanism. We present a computational technique that is able to determine such stable methylation pa…
Caracterización clínica y epigenomica de la Hidradenitis Superlativa
2022
La Hidradenitis Supurativa (HS), también conocida como acné́ inverso o enfermedad de Verneuil, es una enfermedad dermatológica crónica, inflamatoria, recurrente y progresiva que afecta a las áreas de vello con mayor presencia de glándulas apocrinas. Esta enfermedad perjudica de forma severa la calidad de vida del paciente, ya que además de ser un proceso patológico de elevada importancia, su repercusión no es únicamente psicológica, sino que también lleva asociada una limitación física, de las relaciones interpersonales, de autoestima y de la percepción de la imagen personal y publica. Actualmente no se sabe con exactitud la genética que provoca esta enfermedad, pero se ha estudiado que, a …
Impacto de la variación en el número de copias y del estado de metilación de genes supresores de tumor en las vías de progresión del meningioma
2015
El meningioma es el tumor del sistema nervioso central más frecuente en la edad adulta, con una incidencia superior al 30% y una evidente predominancia femenina. La sintomatología deriva fundamentalmente de la localización del tumor, que crece desde las células de la cubierta aracnoidea. El tratamiento es principalmente quirúrgico, y su radicalidad se relaciona clásicamente con la aparición de recidivas tumorales, que es la principal complicación que sufren los afectados. Macroscópicamente, son tumores habitualmente bien delimitados y encapsulados, de crecimiento lento, y microscópicamente la OMS los clasifica en 16 subtipos histológicos. Son tumores positivos para vimentina y EMA, y en men…
"Frater, ave atque vale" (Catull. 101.10): fortuna literaria de una fórmula epigráfica
2011
Trabajo realizado dentro del Grupo de Investigación «Tradiciones Clásicas» de la UPV/EHU (GIU-07-26) [ES] En este artículo ofrecemos un panorama con algunos de los autores modernos –Tennyson, Swinburne, V. Woolf, G. Moore, C.K. Stead y Anne Carson– que han dado nueva vida al motivo del saludo directo al difunto, a partir del carmen 101 de Catulo, cuyo verso 10 sigue gozando de un especial éxito, apoyado por la efectiva simplicidad de su saludo emotivo al hermano y de su forma, asequible y reconocible aun cuando el conocimiento de la lengua latina sea menor. [EN] In this article we offer an overview of some of the modern authors (specially Tennyson, Swinburne, V. Woolf, G. Moore, C.K. Stead,…
Decorated pottery study: Analysis of pigments by x-ray absorbance spectroscopy measurements
2007
Characterization of pigments on decorated pottery fragments has been fully carried out by nondestructive x-ray absorbance spectroscopy (XAS). The samples were a series of pottery shards excavated from the archeological site of Caltagirone (Sicily, Italy), a well-known ceramic production center. Aesthetical criteria and morphological observations allowed us to attribute the samples to quite different historical periods, starting from the 18th century B.C. up to the 16th century A.D. An extensive time interval led us to suppose that different materials and techniques were used for the production of the ceramic paste and also for the preparation of pigments. XAS measurements were performed at …
Yield measurements at IGISOL with a digital data acquisition system
2017
A new digital data acquisition system has been installed at the IGISOL facility at the department of Physics in University of Jyväskylä in November, 2016. The technical details of the hardware and software of this new system are presented in this thesis. Nutaq VHS-ADC digital data acquisition system includes an analogue to digital converter (ADC) crate board, an offset unit box, an acquisition host PC, and a storage drive. This system consists of 8 channels, has the capability of 105 MSPS with 14-bit ADCs on 6U cPCI (PXI compatible). Radioactive sources, beta-gamma matrix, gamma-gamma matrix, beta-delayed gamma, and gamma-delayed gamma spectra of radioactive isotopes produced at IGISOL were…
Glíptica en grafía árabe del Museo Arqueológico Nacional
2018
El trabajo presenta las doce piedras con inscripción en alfabeto árabe que se guardan en la sección de glíptica del MAN, casi todas las cuales permanecían inéditas. Incluye la descripción y medidas de cada una, lectura y traducción de su texto, y paralelos en otros centros. Comenta los estilos caligráficos y demás aspectos que las insertan en el contexto de los sellos o de las manifestaciones de piedad popular a que corresponden, según los casos. Recoge información para determinar cómo y cuándo llegaron al Museo y su posible procedencia. La conclusión es que no tienen origen andalusí, sino que se trajeron de Oriente (India, Irán o Turquía) o del Norte de África (Túnez) durante el siglo xix.…
ANP and vasopressin -presence in the ciliary body of eye in the pig, (Sus domesticus)
2014
The aqueous humor is produced in the ciliary body so, in this study we investigate on the ANP presence and vasopressin in the ciliary body of the pig eye since these peptide are involved in the homeostasis of the body fluids. The results show ANP-presence in the epithelial cells and in the endothelial cells of the blood vessels and VP-presence in the epithelial cells, in the endothelium of canal of Schelmm and in the muscle cells of the blood vessels. These peptides might regulate the synthesis and the composition of the aqueous humor and regulate the hydrodynamic flow and haemodynamic flow of the blood.