Search results for "plastic"
showing 10 items of 7296 documents
The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
2021
Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are capable of modulating pathophysiological conditions at the cellular and systemic levels. An example is the high level of HSP expression in neoplastic tissues, which disrupts the apoptosis of transformed cells and promotes the processes of proliferation, invasion, and metastasis. In addition, an increasing amount of information is appearing about the participation of HSPs in the formation of multi…
Patent number PA2010 A 000023: Sistema biocompatibile di supporto per la piantumazione di organismi vegetali in ambiente marino
2010
Il brevetto consiste in un sistema a basso impatto ambientale, realizzato interamente in bioplastica, per il fissaggio sul fondo marino in forma rapida ed efficace di organismi vegetali, allo scopo di garantirne l'attecchimento e la crescita, assecondandone la dinamica naturale di sviluppo.
Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review
2019
The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: 'the great simulator;' (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with cl…
Familial risk-colorectal cancer: ESMO Clinical Practice Guidelines.
2013
J. Balmana1, F. Balaguer2, A. Cervantes3 & D. Arnold4, on behalf of the ESMO Guidelines Working Group* Department of Medical Oncology, Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO), Universitat Autonoma de Barcelona, Barcelona; Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona; Department of Hematology and Medical Oncology, INCLIVA, University of Valencia, Valencia, Spain; Department of Medical Oncology, Tumor Biology Clinic, Albert Ludwigs University, Freiburg, Germany;
Risk of scleroderma according to the type of immune checkpoint inhibitors
2020
Abstract Introduction Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs). Among them, ICIs-induced systemic sclerosis (SSc) is poorly known. Methods To better characterize this irAE, our comprehensive approach combined the description of ICIs-induced scleroderma cases, the systematic review of the literature and the analysis of VigiBase, the WHO pharmacovigilance database. Results We identified two cases with underlying limited cutaneous SSc who presented a dramatic increase in the skin thickening following pembrolizumab, associated with scleroderma renal crisis in one case. In the literature, four cases of scleroderma and four cases of morphea hav…
Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations
2016
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This pa…
Bending effect on the risk for delamination at the reinforcement/matrix interface of 3D woven fabric composite using a shell-like RVE
2012
This paper presents a computational homogenisation-based technique for flexural effects in textile reinforced composite planar shells. An homogenisation procedure is used for the in-plane and the out-of-plane behaviour of three-dimensional woven composite shells, taking the in-plane periodicity of the material into account while relaxing any periodicity tying in the thickness direction. Several types of damage (matrix or reinforcement cracking, delamination, …) can appear in a composite material. In this paper, material non-linear computations are used to assess the importance of bending on the risk for delamination at the reinforcement/matrix interface. The normal and tangential stresses a…
Delaying surgery for patients with a previous SARS-CoV-2 infection
2020
With at least 28 elective million operations delayed during the first three months of the COVID-19 pandemic, the number of patients who will require surgery after a previous SARS-CoV-2 infection is likely to increase rapidly1. Operating on patients with an active perioperative SARS-CoV-2 infection is now known to carry a very high pulmonary complication and mortality rate2. Urgent information is needed to guide whether postponing surgery in patients with a previous SARS-CoV-2 infection leads to a clinical benefit, and the optimal length of delay.
Active macro-zones algorithm via multidomain SBEM for strain-hardening elastoplastic analysis
2010
In this paper a strategy to perform strain-hardening elastoplastic analysis by using the Symmetric Boundary Element Method (SBEM) for multi-domain type problems is shown. The procedure has been developed inside Karnak.sGbem code by introducing an additional module.
Elastoplastic analysis for active macro-zones via multidomain symmetric Galerkin BEM
2010
In this paper a strategy to perform elastoplastic analysis by using the Symmetric Boundary Element Method (SBEM) for multidomain type problems is shown. This formulation uses a self-stresses equation to evaluate the trial stress in the predictor phase, and to provide the elastoplastic solution in the corrector one. Since the solution is obtained through a return mapping involving simultaneously all the plastically active bem-elements, the proposed strategy does not depend on the path of the plastic strain process and it is characterized by computational advantages due the considerable decrease of the plastic iterations number. This procedure has been developed inside Karnak.sGbem code [1] b…