Search results for "plastic"
showing 10 items of 7296 documents
Il progetto di una morfologia plastica
2019
The present contribution aims to examine the perspectives of a “plastic” morphology, that is, attentive to the theorization of a metamorphosis understood as a radical questioning of the substance and the individuality of the form; starting from Goethe, through the Warburg school and up to Malabou’s research, we intend to illustrate and briefly verify the possibility of such a line of research.
Morfologia e plasticità
2019
Il pensiero morfologico di C. Malabou e la questione della plasticità distruttiva
Autobiografie interrotte. Plasticità distruttrice, riconfigurazioni estetiche e identità accidentali
2023
Che relazione esiste tra il corpo di ciascun individuo e la sua identità individuale? La nostra identità rimane immutata nel tempo, permettendoci di narrare un’autobiografia lineare, o possono sopraggiungere eventi accidentali che contribuiscono a modificarla radicalmente, dando vita a una nuova versione di noi stessi, a una nuova storia? In questo articolo ci proponiamo di rispondere a tali domande partendo dalle riflessioni della pensatrice francese Catherine Malabou. Affronteremo il problema della costruzione e della decostruzione dell'identità individuale alla luce dell'ontologia dell'incidente, analizzando il concetto di plasticità negativa e cercando di delineare come un evento accide…
Plasticity
2023
Although the expression πλαστική τέχνη has Greek origins, the derivative term Plasticity enters European languages only in the Modern Age and it is strictly linked to the domain of art. Notably, Plasticity is the art of manipulating a ductile substance (like wax) to create a work of art or a three-dimensional preparatory model. Aesthetics was concerned with this concept mostly referring to that definition, the fulcrum of a key text of eighteenth-century reflection, the Plastik of Herder. Today this concept has again become central in the aesthetic field thanks to Catherine Malabou – a student of Derrida and one of the most influential thinkers in contemporary French debate –, in whose refle…
Transumanesimo e postumanesimo alla luce della plasticità
2019
Postumanesimo e transumanesimo condividono la stessa idea: l’“uomo di oggi” è l’anticipazione di qualcosa di nuovo. I promotori di tali movimenti teorici sono convinti che la farmacologia, la nanotecnologia, la manipolazione genetica e le tecno-scienze plasmeranno una nuova umanità. L’essere umano si caratterizza, infatti, per un’elevata plasticità, concetto analizzato dalla pensatrice francese Catherine Malabou e che indica l’attitudine a dare e ricevere forma. Nella presente trattazione ci proponiamo di chiarire perché il principio di variazione plastica rappresenti il campo di battaglia fra la prospettiva teorica umanista e quella postumanista e, in secondo luogo, di delineare il diverso…
Three Effective Ways to Nurture Our Brain
2017
Abstract. A growing body of research suggests that physical activity, healthy eating, and music can, either directly or indirectly, have positive effects on our brain and cognition. More specifically, exercising and eating seem to enhance cognitive abilities, such as memory, creativity, and perception. They also improve academic performance and play a protective role from many degenerative diseases, including Alzheimer’s disease. Concerning music, research has shown that there exists a general positive relation between music aptitude and cognitive functioning. Furthermore, the presence of music seems to create a positive mood and a higher arousal, which translates into better performance i…
Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel?
2015
Introduction: Sorafenib is currently the only approved therapy in hepatocellular carcinoma (HCC). Alternative first- and second-line treatments are a significant unmet medical need, and several biologic agents have been tested in recent years, with poor results. Therefore, angiogenic pathways and the cytokine cascade remain possible targets in HCC. Recent studies suggest a role of epigenetic processes, associated with the initiation and development of HCC. In this field, DNA methylation, micro-RNAs (miRNAs) and tumor microenvironment cells became a possible new target for HCC treatment. Areas covered: This review explains the possible role of DNA methylation and histone deacetylase inhibito…
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.
2007
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 ( TP53INP1 ) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s.c., i.p., and intrapancreatic tumors in nude mice. This anti-tumoral capacity is, at least in part, due to the induction of caspase 3-mediated apoptosis. In addition, TP53INP1 −/− mouse embryonic…
HSP-MOLECULAR CHAPERONES IN CANCER BIOGENESIS AND TUMOR THERAPY: AN OVERVIEW
2012
Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by "mistake". In the latter case, the chaperone is structurally and functionally normal but paqrtecipates in pathwais that favor diseases, aòlthough in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in acrcinogenesis in various ways, so that some forms of …