Search results for "points"
showing 10 items of 415 documents
Nonlinear elliptic equations involving the p-Laplacian with mixed Dirichlet-Neumann boundary conditions
2019
In this paper, a nonlinear differential problem involving the \(p\)-Laplacian operator with mixed boundary conditions is investigated. In particular, the existence of three non-zero solutions is established by requiring suitable behavior on the nonlinearity. Concrete examples illustrate the abstract results.
Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives
2016
The new therapeutic approach of using immune checkpoint inhibitors as anticancer agents is a landmark innovation. Early studies suggest that immune checkpoint inhibition might also be effective in patients with gastrointestinal cancer. To improve the efficacy of immunotherapy, different strategies are currently under evaluation. This review summarises the discussion during the European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Translational Research Meeting in Mainz in November 2014 and provides an update on the most recent results of immune therapy in gastrointestinal cancers. Knowledge of potential relationships between tumour cells and their microenv…
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation.
2012
The spindle assembly checkpoint (SAC) is a cellular surveillance mechanism that ensures faithful chromosome segregation during mitosis and its failure can result in aneuploidy. Previously, it was suggested that reduction of the MAD2 gene, encoding a major component of the SAC, induced aneuploidy in human tumor cells. However, tumor cell lines contain multiple mutations that might affect or exacerbate the cellular response to Mad2 depletion. Thus, the scenario resulting by Mad2 depletion in primary human cells could be different and more complex that the one depicted so far. We used primary human fibroblasts (IMR90) and epithelial breast cells (MCF10A) to gain further insight on the effects …
Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents.
2020
Abstract Human cancers frequently harbour mutations in DNA repair genes, rendering the use of DNA damaging agents as an effective therapeutic intervention. As therapy-resistant cells often arise, it is important to better understand the molecular pathways that drive resistance in order to facilitate the eventual targeting of such processes. We employ recombination-defective diploid yeast as a model to demonstrate that, in response to genotoxic challenges, nearly all cells eventually undergo checkpoint adaptation, resulting in the generation of aneuploid cells with whole chromosome losses that have acquired resistance to the initial genotoxic challenge. We demonstrate that adaptation inhibit…
Mobility Limitation and Changes in Personal Goals Among Older Women.
2016
Objectives. Several theoretical viewpoints suggest that older adults need to modify their personal goals in the face of functional decline. The aim of this study was to investigate longitudinally the association of mobility limitation with changes in personal goals among older women. Method. Eight-year follow-up of 205 women aged 66–78 years at baseline. Results. Health-related goals were the most common at both measurements. Goals related to independent living almost doubled and goals related to exercise and to cultural activities substantially decreased during the follow-up. Higher age decreased the likelihood for engaging in new goals related to cultural activities and disengaging from g…
Electronic government and corruption: Systematic literature review, framework, and agenda for future research
2021
Abstract The notion of corruption has emerged as a prominent topic against the backdrop of e-government. However, there are diverse but disorganized viewpoints about the relationship between e-government and corruption, thus creating difficulties in obtaining a structured overview of the existing literature and identifying the avenues to take this research area forward. Despite this, prior studies have made limited attempts to gather these fragmented observations to guide future research holistically. To address this concern, we conduct a systematic literature review (SLR) of 63 articles discussing e-government and corruption and provide a comprehensive synthesis of the current knowledge in…
Multiple constituency evaluation in sport policy
2004
AbstractThe purpose of this study is to show, how the evaluation process worked, when evaluation method was the multiple constituency evaluation procedure. The research material was Finnish state government’s platform during the years 1995-2003 and also government’s sport policy impacts to Sport Policy in European Union. The goal and objective of modern evaluation research in Sport Policy is to chart, or even call into question, societal functions and programmes. Policy-analytical evaluation research has in Sport Policy been characterised as being too goal oriented, which causes problems when adapting set goals into concrete assessment criteria, especially in the evaluation of public activi…
The Importance of the Sustainability of the Romanian Convergence Process to the Euro Zone
2018
Abstract Since 2007, Romania has been under the under the glance of experts in the European Union, but also under the strict monitoring of the NBR and also under the pressure of citizens and investors' expectations about the moment of euro adoption. My research concerns have also been channeled to this point of maximum interest, impact and timeliness, which is why I have proposed through this paper to highlight a synthetic situation regarding the fulfillment of the convergence criteria from the moment of accession to the European Union, to the present. The objective of this paper is to reflect, in dynamics and correlation, the degree of fulfillment of the nominal and real convergence criter…
Electron-density critical points analysis and catastrophe theory to forecast structure instability in periodic solids
2018
The critical points analysis of electron density,i.e. ρ(x), fromab initiocalculations is used in combination with the catastrophe theory to show a correlation between ρ(x) topology and the appearance of instability that may lead to transformations of crystal structures, as a function of pressure/temperature. In particular, this study focuses on the evolution of coalescing non-degenerate critical points,i.e. such that ∇ρ(xc) = 0 and λ1, λ2, λ3≠ 0 [λ being the eigenvalues of the Hessian of ρ(x) atxc], towards degenerate critical points,i.e. ∇ρ(xc) = 0 and at least one λ equal to zero. The catastrophe theory formalism provides a mathematical tool to model ρ(x) in the neighbourhood ofxcand allo…
Universal formulas for characteristic classes on the Hilbert schemes of points on surfaces
2007
This article can be seen as a sequel to the first author's article ``Chern classes of the tangent bundle on the Hilbert scheme of points on the affine plane'', where he calculates the total Chern class of the Hilbert schemes of points on the affine plane by proving a result on the existence of certain universal formulas expressing characteristic classes on the Hilbert schemes in term of Nakajima's creation operators. The purpose of this work is (at least) two-fold. First of all, we clarify the notion of ``universality'' of certain formulas about the cohomology of the Hilbert schemes by defining a universal algebra of creation operators. This helps us to reformulate and extend a lot of the f…