Search results for "points"

A conjecture on special linear systems of $mathbb{P}^3$

2005

Construction of Whiteness and Blackness in Herman Melville’s Benito Cereno

2020

Rather than resist slavery directly, the narrative world of Benito Cereno disperses the rejection of tyranny through the intricate construction of subject-object relations, the situational context, Benito Cereno’s stifled, semi-articulated statements, the imagery of the narrative and its complex narrative structure. Through silences, multiple viewpoints, innuendos, refusal to solve certain issues definitely while being explicit about this indeterminacy, Melville’s narrative not only inscribes itself in the Romantic questioning of historiography, but also gestures towards postmodernist inconclusiveness and the writerly text in which the reader is invited to be its co-author who fills out the…

Effects of authority: voicescapes in children's beliefs about the learning of English

2012

This paper examines learner beliefs from a dialogical point of view. Drawing on the writings of the Bakhtin circle, it sees beliefs as shared and recycled viewpoints that are multivoiced: they echo the voices of others as well as the voice of the speaker. A longitudinal interview study was conducted among a group of young Finnish learners of English. The analysis of the data focused on the voicework present in the learners' answers: how they, on the one hand, echoed or even repeated the voices of authority, and, on the other hand, brought forward their own insights. The results indicate that the authoritative voices strongly influence how the individual viewpoints are formed and presented a…

Finite-time Lyapunov dimension and hidden attractor of the Rabinovich system

2015

The Rabinovich system, describing the process of interaction between waves in plasma, is considered. It is shown that the Rabinovich system can exhibit a {hidden attractor} in the case of multistability as well as a classical {self-excited attractor}. The hidden attractor in this system can be localized by analytical-numerical methods based on the {continuation} and {perpetual points}. For numerical study of the attractors' dimension the concept of {finite-time Lyapunov dimension} is developed. A conjecture on the Lyapunov dimension of self-excited attractors and the notion of {exact Lyapunov dimension} are discussed. A comparative survey on the computation of the finite-time Lyapunov expon…

The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells.

2011

Lung cancer is a malignant disease with poor outcome, which has led to a search for new therapeutics. The PI3K/Akt/mTOR and Ras/raf/Erk pathways are key regulators of tumor growth and survival. In the present study, their roles were evaluated by MTT assay, flow cytometry and Western blotting in lung cancer cells. We found that a high efficacy of antitumor activity was shown with GDC-0941 treatment in two gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In addition, H460 cells with activating mutations of PIK3CA were relatively more sensitive to GDC-0941 than A549 cells with wild-type PIK3CA. Furthermore, GDC-0941 was highly efficacious in combination with U0…

Involvement of the transcription factor FoxM1 in contact inhibition

2012

Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Although it is generally accepted that contact inhibition plays a pivotal role in maintaining tissue homeostasis, the molecular mechanisms of contact inhibition are still not fully understood. FoxM1 is known as a proliferation-associated transcription factor and is upregulated in many cancer types. Vice versa, anti-proliferative signals, such as TGF-β and differentiation signals decrease FoxM1 expression. Here we investigated the role of FoxM1 in contact inhibition in fibroblasts. We show that protein expression of FoxM1 is severely and rapidly downregulated upon contact inhibition, probably by inhibiti…

The relationship between debt level and fiscal sustainability in organization for economic cooperation and development countries

2014

In this article we unify the traditional approaches to testing for fiscal sustainability considering the stock-flow system that fiscal variables configure. Our approach encompasses previous ways of testing for sustainability. The results obtained for a group of 17 Organization for Economic Cooperation and Development (OECD) countries point to weak fiscal sustainability, as well as to the existence of cointegration between deficit and debt, confirming the relevance of the stock-flow approach. Allowing for structural breaks and multicointegration turns out to be of critical importance to assess whether the fiscal authorities apply their policies looking for sustainability and whether, simulta…

Balance of payments crises and fiscal adjustment measures

1991

A model with optimizing firms and consumers is used to explore the effects of unannounced and preannounced fiscal adjustment policies that are intended to prevent an impending balance of payments crisis. It is shown that preannouncement unambiguously raises the required fiscal adjustment effort so that, from the government's point of view, “cold turkey” is the preferable policy. The effect of preannouncement on the private sector's adjustment cost is ambiguous since preannouncement induces an externality which may either benefit or harm the private sector, depending on the nature of the measure that is preannounced.

Fiscal Devaluations in EMU

2013

2013SummaryWe use a small open economy general equilibrium model to analyse the effects of a fiscal devalua-tion in an EMU country. The model has been calibrated for the Spanish economy, which is a goodexample of the advantages of a change in the tax mix given that its tax system shows a positive biasin the ratio of social security contributions over consumption taxes. The preliminary empirical evi-dence for European countries shows that this bias was negatively correlated with the current accountbalance in the expansionary years leading up to the 2009 crisis, a period when many EMU membersaccumulated large external imbalances. Our simulation results point to significant positive effects of…

Trade Openness and Income: A Tale of Two Regions

2015

In this article we present evidence of the long-run effect of trade openness on income per worker for two regions that have followed different liberalization strategies, namely Asia and Latin America. A model that re-examines these questions is estimated for two panels of Asian and Latin American countries over the 1980-2008 period using a novel empirical approach that accounts for endogeneity as well as for the time series properties of the variables involved. From an econometric point of view, we apply recent panel cointegration techniques based on factor models that account for two additional elements usually neglected in previous empirical literature: cross-dependence and structural bre…