Search results for "positioning"

First GPS-tracking of Cory’s shearwater in the Mediterranean Sea.

2010

Abstract The behaviour and ecology of seabirds such as albatrosses, petrels and shearwaters have been the subject of numerous studies, often employing the most recent technologies to track birds during their foraging trips. Until now, however, large oceanic species have been preferred for tracking studies because of the dimensions and weight of the devices available. New light-weight GPS (Global Positioning System) loggers (< 9 g) were used to track foraging trips of a medium-sized species, the Cory's shearwater, for the first time in the Mediterranean Sea. The tracks obtained showed that Mediterranean Cory's shearwaters alternatively used one of two different fishing areas. Various explana…

LynxNet: Wild Animal Monitoring Using Sensor Networks

2010

Monitoring wild animals, especially those that are becoming endangered (for example, lynxes and wolves) is important for biology researchers. Solutions for the monitoring already exist; however, they all have drawbacks, such as limited range or lifetime, sensing modality, reporting delays, unreliability of operation. In this work we describe our experiences in designing an improved animal monitoring sensor system and low-level software for sensor node control and communication. The target animals for this particular research are wild lynxes or canines, however it can be extended to other animal species. The LynxNet system is based on tracking collars, built around TMote Mini sensor nodes, s…

In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection

2020

COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). This work proposes a repurposing process using a database containing approximately 8000 known drugs in synergy structure- and ligand-based studies by means of the molecular docking and descriptor-based protocol. The proposed in silico findings identified new potential SARS CoV-2 main protease (MPRO) inhibitors that fit in the catalytic binding site of SARS CoV-2 MPRO. Several sel…

The Repurposing of Old Drugs or Unsuccessful Lead Compounds by in Silico Approaches: New Advances and Perspectives

2015

Have you a compound in your lab, which was not successful against the designed target, or a drug that is no more attractive? The drug repurposing represents the right way to reconsider them. It can be defined as the modern and rationale approach of the traditional methods adopted in drug discovery, based on the knowledge, insight and luck, alias known as serendipity. This repurposing approach can be applied both in silico and in wet. In this review we report the molecular modeling facilities that can be of huge support in the repurposing of drugs and/or unsuccessful lead compounds. In the last decades, different methods were proposed to help the scientists in drug design and in drug repurpo…

Identification of potential inhibitors targeting BRAF-V600E mutant melanoma cells.

2020

Technique detection of cross-country ski classical race using kinematic GNSS

2018

Studying Nucleosomes Positioning by a Multi-Layer Model

2007

Eukaryotic DNA is packaged into a highly compact and dynamic structure called chromatin. While this packaging allows the cell to organize a large and complex genome in the nucleus, it can also block the access of transcription factors and other proteins to DNA. Nucleosomes are the fundamental repeating units of eukaryotic chromatin. Nucleosome position can be regulated in vivo by multi-subunit chromatin remodeling complexes, and their position can influence gene expression in eukaryotic cells. Alterations in chromatin structure, and hence in nucleosome organization, can result in a variety of diseases, including cancer, highlighting the need to achieve a better understanding of the molecula…

Acetylated nucleosome assembly on telomeric DNAs

2003

Abstract The role of histone N-terminal domains on the thermodynamic stability of nucleosomes assembled on several different telomeric DNAs as well as on ‘average’ sequence DNA and on strong nucleosome positioning sequences, has been studied by competitive reconstitution. We find that histone tails hyperacetylation favors nucleosome formation, in a similar extent for all the examined sequences. On the contrary, removal of histone terminal domains by selective trypsinization causes a decrease of nucleosome stability which is smaller for telomeres compared to the other sequences examined, suggesting that telomeric sequences have only minor interactions with histone tails. Micrococcal nuclease…

Cardiopulmonary resuscitation in prone position: A scoping review.

2020

Introduction The ongoing pandemic of COVID-19 brought to the fore prone positioning as treatment for patients with acute respiratory failure. With the increasing number of patients in prone position, both spontaneously breathing and mechanically ventilated, cardiac arrest in this position is more likely to occur. This scoping review aimed to summarize the available evidence on cardiopulmonary resuscitation in prone position (‘reverse CPR’) and knowledge or research gaps to be further evaluated. The protocol of this scoping review was prospectively registered on 10th May 2020 in Open Science Framework (https://osf.io/nfuh9). Methods We searched PubMed, EMBASE, MEDLINE and pre-print repositor…

Change Talk in Hospital Management Groups

2020

Recent national healthcare reforms have resulted in many changes to healthcare organizations. When social realities are enacted in social interactions, changes also occur in communication through discourses. In public hospitals, middle management groups form one important platform for change talk. This study aimed to identify and understand how change talk emerges in management group meetings. Data were collected from 10 hospital meetings, and change-related interactions were explored by analyzing sensemaking and positioning. In the data, change talk took three forms: collaboration, control and confrontation. These forms consisted of change discourses (change as a possibility, concealed cha…