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showing 10 items of 6213 documents

The synthetic cannabinoid 5F-MDMB-PICA: A case series

2020

5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since 2016. It is associated with serious adverse health and behavioral effects and even death. Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities, four cases of driving under the influence of drugs and five other criminal acts. In these cases, 5F-MDMB-PICA was detected in postmortem blood or serum. Concentrations ranged from 0.1-16ng/mL. In some blood (serum) and urine samples, the hydrolysis metabolite of 5F-MDMB-PICA (M12) could also be detected. In this case series, co-consumption with other drugs occurred in 9 of 12 cases, most commonly alcohol…

AdultMaleSubstance-Related Disordersmedicine.medical_treatmentPhysiology01 natural sciencesMass SpectrometryPathology and Forensic Medicine03 medical and health sciences0302 clinical medicineLimit of DetectionPupil DisordersSynthetic cannabinoidsmedicineHumans030216 legal & forensic medicinePica (disorder)ConfusionAdverse effectDriving Under the InfluencePostural BalanceDriving under the influenceSlurred speechMolecular StructurebiologyCannabinoidsIllicit DrugsMood Disordersbusiness.industrySolid Phase Extraction010401 analytical chemistrycelebritiesPostmortem bloodMiddle Agedbiology.organism_classification0104 chemical sciencesAggressioncelebrities.reason_for_arrestSensation DisordersFemaleCrimeCannabinoidCannabismedicine.symptombusinessConjunctivaLawChromatography Liquidmedicine.drugForensic Science International
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Mechanisms of causal interaction between short-term RR interval and systolic arterial pressure oscillations during orthostatic challenge

2013

The transition from the supine to the upright position requires a reorganization of the mechanisms of cardiovascular control that, if not properly accomplished, may lead to neurally mediated syncope. We investigated how the patterns of causality between systolic arterial pressure (SAP) and cardiac RR interval were modified by prolonged head-up tilt using a novel nonlinear approach based on corrected conditional entropy (CCE) compared with the standard approach exploiting the cross-correlation function (CCF). Measures of coupling strength and delay of the causal interactions from SAP to RR and from RR to SAP were obtained in 10 patients with recurrent, neurally mediated syncope (RNMS) and 10…

AdultMaleSupine positionAdolescentPhysiologyPostureBaroreflexCardiovascular SystemSyncopeCardiovascular Physiological PhenomenaElectrocardiographyYoung AdultTilt table testOrthostatic vital signsNeurally mediated syncopeTilt-Table TestPhysiology (medical)medicineAutonomic nervous systemHumansArterial PressureCardiovascular Physiological PhenomenaAgedmedicine.diagnostic_testbusiness.industryHead-up tiltCrosscorrelationHeartBaroreflexMiddle AgedAutonomic nervous systemBlood pressureCardiovascular controlCase-Control StudiesAnesthesiaSettore ING-INF/06 - Bioingegneria Elettronica E InformaticaFemaleConditional entropybusinessElectrocardiographyJournal of Applied Physiology
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Acute Physiological Responses to Four Running Sessions Performed at Different Intensity Zones

2020

AbstractThis study investigated acute responses and post 24-h recovery to four running sessions performed at different intensity zones by supine heart rate variability, countermovement jump, and a submaximal running test. A total of 24 recreationally endurance-trained male subjects performed 90 min low-intensity (LIT), 30 min moderate-intensity (MOD), 6×3 min high-intensity interval (HIIT) and 10×30 s supramaximal-intensity interval (SMIT) exercises on a treadmill. Heart rate variability decreased acutely after all sessions, and the decrease was greater after MOD compared to LIT and SMIT (p<0.001; p<0.01) and HIIT compared to LIT (p<0.01). Countermovement jump decreased only after …

AdultMaleSupine positionTime FactorskestävyysharjoitteluMovementpalautuminenPhysical ExertionPhysical Therapy Sports Therapy and RehabilitationAutonomic Nervous SystemInterval trainingRunningjuoksuRandom AllocationYoung Adultrecoveryendurance trainingEndurance trainingHeart RateHeart rate variabilityMedicineHumansOrthopedics and Sports MedicineLactic AcidTreadmillsubmaximal running testinterval trainingcountermovement jumpbusiness.industryheart rate variabilityRecovery of FunctionintervalliharjoitteluPhysiological responsesParasympathetic Fibers PostganglionicIntensity (physics)AthletesAnesthesiaCountermovement jumpExercise TestPhysical Endurancebusiness
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An ensemble analysis of electromyographic activity during whole body pointing with the use of support vector machines.

2011

Import JabRef | WosArea Life Sciences and Biomedicine - Other Topics; International audience; We explored the use of support vector machines (SVM) in order to analyze the ensemble activities of 24 postural and focal muscles recorded during a whole body pointing task. Because of the large number of variables involved in motor control studies, such multivariate methods have much to offer over the standard univariate techniques that are currently employed in the field to detect modifications. The SVM was used to uncover the principle differences underlying several variations of the task. Five variants of the task were used. An unconstrained reaching, two constrained at the focal level and two …

AdultMaleSupport Vector MachineNeural NetworksComputer sciencePosturelcsh:MedicineElectromyographyKinematicsMotor ActivityDIAGNOSISCLASSIFICATIONTask (project management)03 medical and health sciences0302 clinical medicineDiscriminative modelmedicineHumanslcsh:ScienceMuscle SkeletalBiology030304 developmental biologyComputational NeuroscienceMotor Systems0303 health sciencesCOORDINATIONMultidisciplinaryMOVEMENTSmedicine.diagnostic_testbusiness.industryElectromyographylcsh:RUnivariateMotor controlPattern recognitionBiomechanical PhenomenaSupport vector machineKernel methodEQUILIBRIUMPATTERNSARM[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]lcsh:QArtificial intelligencebusiness030217 neurology & neurosurgeryResearch ArticleNeurosciencePloS one
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Quantitative and qualitative analysis of DNA extracted from postmortem muscle tissues

1990

DNA extracted from 33 postmortem muscle specimens was analyzed using MZ 1.3, a hypervariable minisatellite probe, as well as locus-specific minisatellite probes (g3, MS1 and MS43). After storage at -25 degrees C for 10 months, DNA from all the samples was partially (approximately 21% of total DNA) degraded even when autopsy was performed 1 day postmortem. However, more than 90% of DNA samples up to at least 3 days postmortem were suitable to obtain good restriction fragment length polymorphism (RFLP) patterns. When small strips of specimen were stored for 8 days at room temperature in moist chambers, approximately 42% of total DNA was degraded. Only 30% of these DNA samples still showed goo…

AdultMaleTime FactorsAdolescentBiologyDNA SatellitePostmortem ChangesPathology and Forensic Medicinechemistry.chemical_compoundDeath SuddenQualitative analysisHumansChildAgedMultiple TraumaHybridization probeMusclesDNAMiddle AgedDNA extractionMolecular biologyMolecular WeightMinisatellitechemistryDNA profilingAccidents AviationPostmortem ChangesFemaleRestriction fragment length polymorphismAnatomyBurnsDNA ProbesDNAPolymorphism Restriction Fragment LengthZeitschrift f�r Rechtsmedizin
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Investigating centre of mass stabilisation as the goal of posture and movement coordination during human whole body reaching

2000

In the light of experimental results showing significant forward centre of mass (CoM) displacements within the base of support, this study investigated if whole body reaching movements can be executed whilst keeping the CoM fixed in the horizontal axis. Using kinematic simulation techniques, angular configurations were recreated from experimental data imposing two constraints: a constant horizontal position of the CoM and an identical trajectory of the hand to grasp an object. The comparison between recorded and simulated trials showed that stabilisation of the CoM was associated with greater backward hip displacements, which became more marked with increasing object distance. This was in c…

AdultMaleTime FactorsAdolescentGeneral Computer ScienceMovementPostureKinematicsPressuremedicineHumansTorqueComputer SimulationPostural BalanceJoint (geology)SimulationMathematicsHipMovement (music)Body WeightHandGeodesyBiomechanical Phenomenamedicine.anatomical_structureTorqueHorizontal position representationTrajectoryFemaleJointsAnkleConstant (mathematics)MathematicsPsychomotor PerformanceBiotechnologyBiological Cybernetics
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Exogenous and endogenous provocation of psoriasis. A contribution to the Koebner phenomenon.

1974

Previous literature reports as well as own investigations concerning exogenously and endogenously induced Koebner-reactions in psoriatics are presented. The time interval between irritation and the Koebner-reaction is emphasized. It is proposed, that the intensity of the psoriatic reaction is mediated by circulating DHEA-deficiency. Hypothetical models are presented which allow to explain the different developmental rates of psoriatic lesions in relation to the type of irritation, the area affected and the subsequent proliferative responses.

AdultMaleTime FactorsAdolescentProvocation testKoebner phenomenonEndogenyDermatologymedicine.disease_causeInfectionsFoodborne DiseasesPostoperative ComplicationsPsoriasisPhysical StimulationSkin ManifestationsInfluenza HumanCyclic AMPMedicinePsychological stressHumansPsoriasisChildSkinSkin manifestationsbusiness.industryVaccinationGeneral MedicineDehydroepiandrosteroneSyndromeMiddle Agedmedicine.diseaseStimulation ChemicalMycosesImmunologyWounds and InjuriesFemaleIrritationbusinessStress PsychologicalArchiv fur dermatologische Forschung
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Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men

2004

The aim of the present study was to evaluate whether olive oils high in phenolic compounds influence the oxidative/antioxidative status in humans. Healthy men (n = 12) participated in a double-blind, randomized, crossover study in which 3 olive oils with low (LPC), moderate (MPC), and high (HPC) phenolic content were given as raw doses (25 mL/d) for 4 consecutive days preceded by 10-d washout periods. Volunteers followed a strict very low-antioxidant diet the 3 d before and during the intervention periods. Short-term consumption of olive oils decreased plasma oxidized LDL (oxLDL), 8-oxo-dG in mitochondrial DNA and urine, malondialdehyde in urine (P < 0.05 for linear trend), and increased HD…

AdultMaleTime FactorsMedicine (miscellaneous)Urinemedicine.disease_causeDNA MitochondrialAntioxidantschemistry.chemical_compoundDouble-Blind MethodPhenolsMalondialdehydemedicineHumansPlant OilsPhenolsFood scienceOlive OilGlutathione PeroxidaseNutrition and DieteticsCross-Over StudiesDose-Response Relationship DrugCholesterolCholesterol HDLDeoxyguanosineMalondialdehydePostprandial PeriodDietLipoproteins LDLDose–response relationshipVegetable oilPostprandialchemistryBiochemistry8-Hydroxy-2'-DeoxyguanosineOxidation-ReductionOxidative stress
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Relationship between isokinetic performance and ballistic movement

1983

The present experiments were carried out to assess the relationship between the mechanical behaviour of the leg extensor muscles in 12 male athletes during activities of a ballistic type and torque production, during: (1) torque production during isokinetic contraction: (2) ballistic type activities (vertical jumps from statis position = SJ, with counter-movement equal CMJ and after a fall from different heights equal DJ) and (3) a new anaerobic test (Bosco 1983a). This consisted of performing continuous jump work for a certain period of time (e.g., 60 s). Both ballistic activities and anaerobic power tests demonstrated the highest relationship with peak torques when this was developed resp…

AdultMaleTime FactorsPhysiologyMovementAccelerationPostureConcentricmedicine.disease_causeJumpingIsometric ContractionPhysiology (medical)medicineHumansEccentricTorqueOrthopedics and Sports MedicinePhysicsLegAltitudeWork (physics)Public Health Environmental and Occupational HealthBallistic movementGeneral MedicineMechanicsBiomechanical PhenomenaClassical mechanicsmedicine.anatomical_structureJumpAnaerobic exerciseMuscle ContractionSportsEuropean Journal of Applied Physiology and Occupational Physiology
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Forensic microbiology applications: A systematic review.

2019

Abstract According to the Human Microbiome Project (HMP), a healthy human body contains ten times more microbes than human cells. Microbial communities colonize different organs of the body, playing fundamental roles both in human health and disease. Despite the vast scientific knowledge of the role of microbial communities in a living body, little is known at present about microbial changes occurring after death, thus leading many authors to investigate the composition of the thanatomicrobiome and its potential applications in the forensic field. The aim of the following review is to provide a general overview of the advances of postmortem microbiology research, mainly focusing on the role…

AdultMaleTime FactorsTime FactorPostmortem bacterial floraBiologyPostmortem microbiologyLiving bodyPathology and Forensic MedicineMicrobiologyHuman healthBody FluidSettore MED/43 - Medicina LegaleCause of DeathHumansForensic microbiologyForensic microbiology; Postmortem bacterial flora; Postmortem microbiology; Thanatomicrobiome; 2734; Issues Ethics and Legal AspectsDead bodyAgedSkinMicrobiotaBrainHeartForensic MedicineMiddle AgedIsolation (microbiology)Databases BibliographicBody FluidsIssues ethics and legal aspectsThanatomicrobiomePostmortem ChangesFemaleDigestive SystemHumanHuman Microbiome ProjectLegal medicine (Tokyo, Japan)
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