6533b86ffe1ef96bd12cddf8

RESEARCH PRODUCT

Exogenous and endogenous provocation of psoriasis. A contribution to the Koebner phenomenon.

Rosemarie KrappB. MorschesN. HoedeH. Holzmann

subject

AdultMaleTime FactorsAdolescentProvocation testKoebner phenomenonEndogenyDermatologymedicine.disease_causeInfectionsFoodborne DiseasesPostoperative ComplicationsPsoriasisPhysical StimulationSkin ManifestationsInfluenza HumanCyclic AMPMedicinePsychological stressHumansPsoriasisChildSkinSkin manifestationsbusiness.industryVaccinationGeneral MedicineDehydroepiandrosteroneSyndromeMiddle Agedmedicine.diseaseStimulation ChemicalMycosesImmunologyWounds and InjuriesFemaleIrritationbusinessStress Psychological

description

Previous literature reports as well as own investigations concerning exogenously and endogenously induced Koebner-reactions in psoriatics are presented. The time interval between irritation and the Koebner-reaction is emphasized. It is proposed, that the intensity of the psoriatic reaction is mediated by circulating DHEA-deficiency. Hypothetical models are presented which allow to explain the different developmental rates of psoriatic lesions in relation to the type of irritation, the area affected and the subsequent proliferative responses.

yearjournalcountryeditionlanguage
1974-01-01Archiv fur dermatologische Forschung
10.1007/bf00595275https://pubmed.ncbi.nlm.nih.gov/4362930