Search results for "predictive value"

showing 10 items of 927 documents

Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.

2005

Mutations in the Ki-ras and TP53 genes are the most frequently observed genetic alterations in colorectal cancer (CRC). Ki-ras mutations are mostly found in codons 12 and 13, and less in codon 61. The majority of the TP53 mutations occur in the core domain which contains the sequence-specific DNA binding activity of the protein, and they results in loss of DNA binding. Few centres have sufficient patients to collect detailed information in the large numbers required to determine the impact of individual ki-ras and TP53 genotypes on outcome. Moreover, it has been reported that specific genetic alterations, and not any mutation, might play a different biological role in cancer progression. Fo…

Colorectal cancerBiologymedicine.disease_causeBioinformaticsProto-Oncogene Proteins p21(ras)Predictive Value of TestsProto-Oncogene ProteinsGenotypemedicineneoplasmsSurvival rateMutationCancerHematologyPrognosismedicine.diseasePrimary tumorProto-Oncogene Proteins p21(ras)Survival RateOncologyMeta-analysisMutationras ProteinsCancer researchFluorouracilTumor Suppressor Protein p53Colorectal Neoplasms
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Early prediction of coma recovery after cardiac arrest with blinded pupillometry

2017

Objectives Prognostication studies on comatose cardiac arrest (CA) patients are limited by lack of blinding, potentially causing overestimation of outcome predictors and self-fulfilling prophecy. Using a blinded approach, we analysed the value of quantitative automated pupillometry to predict neurological recovery after CA. Methods We examined a prospective cohort of 103 comatose adult patients who were unconscious 48 hours after CA and underwent repeated measurements of quantitative pupillary light reflex (PLR) using the Neurolight-Algiscan® device. Clinical examination, electroencephalography (EEG), somatosensory evoked potentials (SSEP) and serum neuron specific enolase (NSE) were perfor…

Comamedicine.diagnostic_test030208 emergency & critical care medicineElectroencephalography03 medical and health sciences0302 clinical medicineNeurologySomatosensory evoked potentialAnesthesiaPredictive value of testsSeverity of illnessmedicineNeurology (clinical)Pupillary light reflexmedicine.symptomProspective cohort studyPsychology030217 neurology & neurosurgeryPupillometryAnnals of Neurology
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Determination of optimal fluoroscopic angulations for aorto-coronary ostial interventions from coronary computed tomography angiography.

2020

Abstract Background An optimal aorto-coronary angiographic projection, characterized by an orthogonal visualization of the proximal coronary artery, is crucial for interventional success. We determined the distribution of optimal C-arm positions and assessed their feasibility by invasive coronary angiography. Methods Orthogonal aorto-coronary ostial angulations were determined in 310 CT data sets. In 100 patients undergoing subsequent invasive angiography, we assessed if the CT-predicted angulations were achievable by the C-arm system. If the predicted projection was not achievable due to mechanical constraints of the C-arm system, the most close, achievable angulation was determined. Patie…

Computed Tomography Angiography030204 cardiovascular system & hematologyBody weightCoronary Angiography030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinePredictive Value of TestsMedicineHumansRadiology Nuclear Medicine and imagingComputed tomography angiographymedicine.diagnostic_testbusiness.industryCoronary computed tomography angiographyInvasive coronary angiographyCoronary ostiumOstiummedicine.anatomical_structureFluoroscopyAngiographycardiovascular systemCardiology and Cardiovascular MedicinebusinessNuclear medicineTomography X-Ray ComputedArteryJournal of cardiovascular computed tomography
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A kernel support vector machine based technique for Crohn’s disease classification in human patients

2017

In this paper a new technique for classification of patients affected by Crohn’s disease (CD) is proposed. The proposed technique is based on a Kernel Support Vector Machine (KSVM) and it adopts a Stratified K-Fold Cross-Validation strategy to enhance the KSVM classifier reliability. Traditional manual classification methods require radiological expertise and they usually are very time-consuming. Accordingly to three expert radiologists, a dataset composed of 300 patients has been selected for KSVM training and validation. Each patient was codified by 22 extracted qualitative features and classified as Positive or Negative as the related histological specimen result showed the CD. The eff…

Computer sciencebusiness.industryKernel support vector machineHuman patientK-fold cross-validation020206 networking & telecommunicationsPattern recognition02 engineering and technologyPredictive value030218 nuclear medicine & medical imagingSupport vector machine03 medical and health sciences0302 clinical medicine0202 electrical engineering electronic engineering information engineeringClassification methodsCrohn disease classificationArtificial intelligencebusinessClassifier (UML)
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Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary …

2009

This was a prospective, multicenter study designed to evaluate the utility of MDCT in the diagnosis of coronary artery disease (CAD) in patients scheduled for elective coronary angiography (CA) using different MDCT systems from different manufacturers. Twenty national sites prospectively enrolled 367 patients between July 2004 and June 2006. Computed tomography (CT) was performed using a standardized/optimized scan protocol for each type of MDCT system (> or =16 slices) and compared with quantitative CA performed within 2 weeks of MDCT. A total of 284 patients (81%) were studied by 16-slice MDCT systems, while 66 patients (19%) by 64-slice MDCT scanners. The primary analysis was on-site/off…

Coronary angiographyAdultDiagnostic ImagingMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary Angiographydiagnosis/radiographyCoronary artery diseasemethodsCoronary artery disease16- and 64-slice MDCT imaging coronary angiographySettore MED/36 - Diagnostica per Immagini e RadioterapiaPredictive Value of TestsCoronary Angiography/*methods Coronary Artery Disease/*diagnosis/*radiography Diagnostic Imaging/methods80 and overCardiac CTMedicineHumansRadiology Nuclear Medicine and imagingIn patientcardiovascular diseasesProspective StudiesProspective cohort studyTomographyNeuroradiologyAgedAged 80 and overmedicine.diagnostic_testbusiness.industryMultidetector CTNon invasiveReproducibility of ResultsInterventional radiologyGeneral MedicineAdult Aged Aged; 80 and over Coronary Angiography; methods Coronary Artery Disease; diagnosis/radiography Diagnostic Imaging; methods Female Humans Italy Male Middle Aged Predictive Value of Tests Prospective Studies Reproducibility of Results Tomography; X-Ray Computed; methodsMiddle Agedmedicine.diseasePredictive valueSettore MED/11 - Malattie Dell'Apparato CardiovascolareX-Ray Computedcoronary angiographyCTCardiac CT; Coronary artery disease; Multidetector CTItalyFemaleRadiologycoronary angiographybusinessTomography X-Ray Computed
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Prognostic outcome of routine clinical noninvasive Multidetector row Computed Tomography Coronary Angiography in Patients with suspected coronary art…

2011

The aim of the study was to assess the prognostic value of multidetector-row CT coronary angiography (MDCT-CA) in patients with suspected coronary artery disease (CAD) in a routine clinical context.A total of 125 patients (82 men, age 57.4±10.3 years) with suspected CAD underwent MDCT-CA. All patients were assessed for cardiovascular risk factors, symptoms and coronary calcium score. A 2-year follow-up study for the occurrence of major adverse cardiac events was performed.According to the Morise pretest score, 76 patients (60.8%) were at intermediate risk. Patients with suspected CAD presented the following prognostic outcome (p0.0001): in 41 patients with normal coronary arteries at MDCT-C…

Coronary angiographyMaleMalattia aterosclerotica coronaricamedicine.medical_specialtyContext (language use)Coronary Artery DiseaseCoronary AngiographySensitivity and SpecificityCoronary artery diseasePredictive Value of TestsInternal medicinemedicineImage Processing Computer-AssistedHumansRadiology Nuclear Medicine and imagingIn patientValore prognosticocardiovascular diseasesCoronary artery disease Prognostic value Coronary angiography Multidetector row computed tomographyNeuroradiologymedicine.diagnostic_testbusiness.industryFollow up studiesInterventional radiologyGeneral MedicineMultidetector row computed tomographyMiddle Agedmedicine.diseasePrognosisPredictive value of testsAngiografia coronaricacardiovascular systemCardiologyFemaleRadiologyTomografia computerizzata multistratobusinessTomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E RadioterapiaPrognostic value
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The German CPU Registry: Dyspnea independently predicts negative short-term outcome in patients admitted to German Chest Pain Units.

2015

While dyspnea is a common symptom in patients admitted to Chest Pain Units (CPUs) little is known about the impact of dyspnea on their outcome. The purpose of this study was to evaluate the impact of dyspnea on the short-term outcome of CPU patients.We analyzed data from a total of 9169 patients admitted to one of the 38 participating CPUs in this registry between December 2008 and January 2013. Only patients who underwent coronary angiography for suspected ACS were included. 2601 patients (28.4%) presented with dyspnea.Patients with dyspnea at admission were older and frequently had a wide range of comorbidities compared to patients without dyspnea. Heart failure symptoms in particular wer…

Coronary angiographyMalemedicine.medical_specialtyAcute coronary syndromeChest PainMedizinComorbidityChest painCoronary AngiographyRisk AssessmentPredictive Value of TestsRisk FactorsInternal medicineGermanymedicineHumansIn patientRegistriesAcute Coronary SyndromeMortalityAgedHeart Failurebusiness.industryAge Factorsmedicine.diseasePrognosisComorbidityrespiratory tract diseases3. Good healthDyspneaHeart failurePredictive value of testsPhysical therapyFemalemedicine.symptomCardiology and Cardiovascular MedicineRisk assessmentbusinessInternational journal of cardiology
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Improving diagnostic accuracy of MDCT coronary angiography in patients with mild heart rhythm irregularities using ECG editing

2006

OBJECTIVE. The objective of our study was to compare diagnostic accuracy of MDCT coronary angiography in a population of patients with mild heart rhythm irregularities before and after editing the ECG. SUBJECTS AND METHODS. Thirty-eight patients who underwent MDCT coronary angiography and conventional coronary angiography were enrolled in the study. The inclusion criterion was the presence of mild heart rhythm irregularities (i.e., premature beats; atrial fibrillation; mistriggering; or low heart rate, defined as 40 beats per minute or less) during the scan. All patients underwent MDCT with the following parameters: 16 detectors; collimation, 0.75 mm; gantry rotation time, 375 msec; 120 kV;…

Coronary angiographyMalemedicine.medical_specialtyCardiac Complexes PrematurePopulationContrast MediaDiagnostic accuracyCoronary AngiographySensitivity and SpecificityElectrocardiographyPredictive Value of TestsInternal medicineHeart rateAtrial FibrillationmedicineBradycardiaHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesProspective Studieseducationeducation.field_of_studymedicine.diagnostic_testCardiac cyclebusiness.industryAtrial fibrillationGeneral Medicinearteriography coronary angiography ECG editing heart rhythm MDCT angiographyMiddle Agedmedicine.diseaseIopamidolHeart Rhythmcardiovascular systemCardiologyFemaleRadiologybusinessTomography X-Ray ComputedElectrocardiography
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Prognostic value of Morise clinical score, calcium score and computed tomography coronary angiography in patients with suspected or known coronary ar…

2011

Our aim was to determine the prognostic value of computed tomography coronary angiography (CTCA), coronary artery calcium scoring (CACS) and Morise clinical score in patients with known or suspected coronary artery disease (CAD). A total of 722 patients (480 men; 62.7 +/- 10.9 years) who were referred for further cardiac evaluation underwent CACS and contrast-enhanced CTCA to evaluate the presence and severity of CAD. Of these, 511 (71%) patients were without previous history of CAD. Patients were stratified according to the Morise clinical score (low, intermediate, high), to CACS (0-10, 11-100, 101-400, 401-1,000, > 1,000) and to CTCA (absence of CAD, nonsignificant CAD, obstructive CAD…

Coronary angiographyMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary AngiographyMorise scoreRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexComputed tomography coronary angiographyCoronary artery diseaseSDG 3 - Good Health and Well-beingPredictive Value of TestsRisk FactorsInternal medicineSeverity of illnessmedicineHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesSurvival analysisNeuroradiologyAgedRetrospective Studiesmedicine.diagnostic_testbusiness.industryCalcinosisRetrospective cohort studyInterventional radiologyGeneral MedicineMiddle Agedmedicine.diseasePrognosisSurvival AnalysisCalcium scoreComputed tomography coronary angiography Prognostic value Prognosis Calcium score Morise scorePredictive value of testsCardiologyFemaleRadiologySettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessTomography X-Ray ComputedPrognostic valueCARDIAC CTAlgorithmsFollow-Up Studies
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Right coronary artery arising from pulmonary trunk: assessment with conventional coronary angiography and multislice computed tomography coronary ang…

2009

We present a case of a 59-year-old man who was admitted to the hospital because of atypical chest pain and dyspnea. Conventional coronary angiography showed an anomalous origin of the right coronary artery from the pulmonary trunk. The patient underwent multislice computed tomography in order to clarify the origin and course of the anomalous vessel. The aim of this report is to emphasize the role of multislice computed tomography as an accurate noninvasive imaging tool in the evaluation of coronary artery anomalies.

Coronary angiographyRight coronary arteryMalemedicine.medical_specialtyCoronary Vessel AnomaliesContrast MediaPulmonary ArteryCoronary AngiographyIopamidolAngina PectorisPredictive Value of Testsmedicine.arterymedicineHumansPulmonary Trunkbusiness.industryGeneral MedicineMultislice computed tomographyMiddle AgedIopamidolmedicine.anatomical_structureDyspneaRight coronary arteryPredictive value of testsPulmonary arteryRadiologyCardiology and Cardiovascular MedicinebusinessTomography X-Ray ComputedArterymedicine.drugJournal of cardiovascular medicine (Hagerstown, Md.)
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