Search results for "presentations"

OS1.5 Harnessing soluble LRIG1 for pan-RTK targeting in glioblastoma

2018

INTRODUCTION: The role of receptor tyrosine kinases (RTKs) in glioblastoma is widely acknowledged. However, therapies based on RTK targeting have been continuously unsuccessful in GBM patients, highlighting the complexity of RTK signaling and biology. LRIG1 (Leucine-rich Repeats and ImmunoGlobulin domains protein 1) was identified as an endogenous inhibitor of epidermal growth factor receptor (EGFR) and other RTKs, and was confirmed as a tumor suppressor in various cancer types. We previously identified the soluble form of LRIG1 as a potent inhibitor of GBM growth in vivo, irrespective of EGFR status. Here, we aim to shed light on the molecular mechanisms underlying its anti-cancer activity…

P01.039 Development of signaling questions assessing distress and quality of life in glioma patients - Results of 50 interviews and an expert analysis

2018

BACKGROUND: Due to cognitive or physical limitations, glioma patients might not be able to validly complete self-reporting tools assessing quality of life, distress, and unmet needs. This not only impairs individual patient care and therapy monitoring but also creates bias in studies applying patient reported outcome measures (PROMs). In our study, we searched for signaling questions implementable in patient-doctor consultations in order to optimize the assessment. METHODS: We performed 1) a literature research to find out the most important questions for glioma patients that are also covered by standard questionnaires. 2) After a pretest in n=10 patients, we performed structured interviews…

P-149: Immunogenicity of SARS-CoV-2 vaccine in patients with multiple myeloma

2021

We evaluated the safety and immunogenicity of the BNT162b2 vaccine in 52 patients with multiple myeloma (MM). Median age was 71.3 (range, 39.6-90.8) years. 26 (50%) patients had received active treatment including an immunomodulatory drug (IMiD) (n=21), an anti-CD38 monoclonal antibody (n=11) and/or a proteasome inhibitor (n=4). 21 had received previous treatment interrupted at a median of 27.5 (range, 3.5-169.3) months before first vaccine inoculum. 5 patients had indolent untreated MM. 35 patients had a history of autologous hematopoietic cell transplantation (HSCT) performed at a median of 44.4 (range, 3.5-169.3) months before first vaccine inoculum. The vaccination was well tolerated wi…

Managers’ and consumers’ representations of the closeness to a store : a contribution to retailer strategy

2013

Getting close to the consumer is one major concern in retailing. This research tries to understand the rehabilitation of small food stores in the French retailing context and explores the notion of closeness in all in its dimensions from a retailer as well as a consumer perspective. The research involves data collection from both retail companies and consumers. The qualitative and quantitative analysis show that creating closeness with the customer can be defined as the management of the spatial, temporal, functional and social distance that links a store to its customers. Seven dimensions can be identified: the access closeness, the functional closeness, the process closeness, the relation…

What Will You Do Next? A Cognitive Model for Understanding Others’ Intentions Based on Shared Representations

2013

Goal-directed action selection is the problem of what to do next in order to progress towards goal achievement. This problem is computationally more complex in case of joint action settings where two or more agents coordinate their actions in space and time to bring about a common goal: actions performed by one agent influence the action possibilities of the other agents, and ultimately the goal achievement. While humans apparently effortlessly engage in complex joint actions, a number of questions remain to be solved to achieve similar performances in artificial agents: How agents represent and understand actions being performed by others? How this understanding influences the choice of ag…

What should I do next? Using shared representations to solve interaction problems

2011

Studies on how “the social mind” works reveal that cognitive agents engaged in joint actions actively estimate and influence another’s cognitive variables and form shared representations with them. (How) do shared representations enhance coordination? In this paper, we provide a probabilistic model of joint action that emphasizes how shared representations help solving interaction problems. We focus on two aspects of the model. First, we discuss how shared representations permit to coordinate at the level of cognitive variables (beliefs, intentions, and actions) and determine a coherent unfolding of action execution and predictive processes in the brains of two agents. Second, we discuss th…

Students’ Redesign of Mandatory Assignments in Teacher Education

2017

This article explores specific aspects of literacy practices in teacher education in Norway, building upon data collected within the research project Digital literacy and use of learning resources in teacher education in Norway (DigiGLU). Our main aim is to explore how teachers in different subject courses in teacher education (TE) design mandatory assignments, and how students respond to these designs. After the extensive TE-reform in 2010, in revised plans and documents guiding professional training, mandatory assignments (both form and content) were considered more important for the students’ learning process. In our investigation, the concepts of design for learning and design in learni…

Corps féminin et representations touristiques: le cas des placards publicitaires des vacances en croisière

2013

Immigrant representations in two newspaper articles from the Daily Telegraph

2009

 Tämän tutkimuksen tarkoituksena oli selvittää millaisia representaatioita ja identiteettikategorioita maahanmuuttajille rakennettiin brittiläisen The Daily Telegraph sanomalehden Internet-sivuilla. Aihe oli sovelias tutkimuksen alaiseksi, koska maahanmuuttajan representaatiosta sanomalehdistössä oli vähän tutkimusta. Ilmiötä oli jonkin verran tutkittu suomenkielisissä sanomalehdissä. Tutkimus oli vertaileva ja metodityökaluna käytettiin kriittistä diskurssianalyysia. Tutkimusaineisto koostui kahdesta artikkelista jotka oli julkaistu joulukuussa 2008. Tutkimuksessa vertailtiin Seija Lambergin pro gradussa listattuja kuutta identiteettikategoriaa tässä tutkimuksessa käytetystä aineistosta es…

P178 Remote monitoring as an effective management strategy in inflammatory bowel disease: the lesson from COVID-19 pandemic

2021

Abstract Background During the COVID-19 outbreaks many IBD clinics in Italy adopted a remote monitoring approach both to ensure an adequate follow-up of patients with inflammatory bowel disease (IBD) and respect the rules of social distancing, while access to hospital was restricted. Aim of the study was to perform a survey on IBD patients submitted to remote monitoring in our tertiary referral center in order to assess adherence and patients’ perceptions and satisfaction as well as their opinions for future monitoring. Changes in disease activity and Quality of Life were also evaluated. Methods Consecutive patients with IBD scheduled for follow-up visits were switched to remote monitoring …