Search results for "proPO"

A new bipartite matching approach for record linkage: the case of two big Italian databases

2022

In recent years, university student mobility in Italy has worsened the north-south economic divide. Therefore, studying this phenomenon and its determinants is necessary to provide helpful information to support socio-economic policies. Thus, this paper aims at integrating two big databases about university students in Italy: the first one is provided by the Ministry of University and Research, concerning the university careers of student cohorts; the second one is provided by the AlmaLaurea consortium, concerning the university experiences of graduates and their success in the labour market. Both databases contain socio-demographic information that complements each other. The proposed meth…

An exploration of reciprocity between female athletes and their coach in elite junior swimming: a shared reality theory perspective

2021

Based on the proposition that the relationship between a coach and athlete is at its best when both parties contribute to enhancing its quality, the present study sought to investigate if Shared Reality Theory could provide new insights on the topic. Specifically, the purpose of the present study was to explore: (a) how a shared reality is established, or fails to be established, over the course of the sporting partnership between athletes and their coach; and (b) how the presence of a shared reality (or not) in the coach-athlete relationship is related to the experienced quality of the relationship between athletes and their coach, as recorded over time. Narrative inquiry, embedded within …

What keeps young adults in permanent poverty? A comparative analysis using ECHP

2009

Abstract Previous studies suggest that there are strong differences in the rates of youth poverty across European countries. Rather surprisingly, it is found to be high in Scandinavian countries, and relatively speaking, lower in Mediterranean and Anglo-Saxon countries. This somewhat unexpected finding prompts the question whether the incidence of poverty is an appropriate measure of youth disadvantage. Instead of considering poverty rates we consider the length of recorded poverty spells, taking into account explicitly the temporal sequencing of the episodes of poverty. Using the European Community Household Panel, individuals are classified into different groups of poverty permanence, eac…

2016

Abstract Public Service Platforms (PSPs) are a new type of technology platform. They are based in the philosophy of New Public Management (NPM) and support public services for citizens in quasi-markets. This article increases our understanding of the business models behind these PSPs in terms of their Value Propositions, structures, networks, and financing. We interviewed representatives from 14 PSP providers in four public sectors in Sweden: education, healthcare, elder care, and public pensions. We identified a “Traditional view” with its focus on public agencies and neutral information and an “Emerging view” that includes dialogues, user evaluations, long-term perspectives on choice, pro…

Sorafenib in advanced hepatocellular carcinoma

2008

none 25 BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Seconda…

Survival analysis of proposed BCLC-B subgroups in hepatocellular carcinoma patients

2013

Background & Aims The BCLC-staging system is used to facilitate treatment decisions in patients with hepatocellular carcinoma (HCC). Owing to the observed clinical heterogeneity of the intermediate stage BCLC-B, a subclassification was proposed taking Child–Pugh score and extended criteria for transplantation into account. Analysis of the prognostic significance of a proposed subclassification of the BCLC-B score in a European cohort of HCC patients. Methods Eight hundred and eighty four consecutive HCC patients were retrospectively analysed. Patients with stage BCLC-B were grouped according to the proposed subclassification. Baseline patient and tumour characteristics, therapy and overall …

Improved prediction of survival by a risk factor-integrated inflammatory score in Sorafenib treated hepatocellular carcinoma

2017

Background and aims Inflammation affects progression of hepatocellular carcinoma (HCC). We therefore postulate that systemic inflammatory markers could help to predict prognosis in HCC patients receiving sorafenib therapy. Methods Overall survival (OS) of HCC patients receiving palliative sorafenib treatment was correlated with the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein to albumin ratio (CAR), Glasgow prognostic score (GPS) and the modified GPS (mGPS) along with clinicopathological parameters. Predictors of OS were assessed by multivariable Cox regression and receiver operating characteristics and area under the curve (ROC-AUC) analyses.…

Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2.

2020

Background & Aims: Limited data on treatment of elderly patients with hepatocellular carcinoma (HCC) increase the unmet need. REACH and REACH-2 were global phase III studies of ramucirumab in patients with HCC after prior sorafenib, where patients with alpha-fetoprotein (AFP) ≥400 ng/mL showed an overall ssurvival (OS) benefit for ramucirumab. These post-hoc analyses examined efficacy and safety of ramucirumab in patients with HCC and baseline AFP ≥ 400 ng/mL by three prespecified age subgroups (<65, ≥65 to <75 and ≥75 years). Methods: Individual patient data were pooled from REACH (baseline AFP ≥400 ng/mL) and REACH-2. Kaplan-Meier and Cox proportional hazards regression methods …

The Criterion of “Consistent and Systematic Manner” in Free Movement Law

2017

The conflict between the four freedoms and national regulation is not merely about colliding interests but also of colliding values and thus has, potentially, constitutional implications. The conflict has often been phrased as one between national sovereignty and European integration, but is far more than this. It is about marked liberalism and market regulation, the latter constituting the very fundament upon which the European welfare states rest. In settling conflicts between the two constitutional orders—the ordo-liberal and the welfare-state constitutions—the Court of Justice of the European Union (CJEU) applies the proportionality principle. However, the proportionality principle is a…

CCDC 706487: Experimental Crystal Structure Determination

2009

Related Article: G.Podoprygorina, M.Bolte, V.Bohmer|2009|Org.Biomol.Chem.|7|1592|doi:10.1039/b819710e