Search results for "programme"
showing 10 items of 874 documents
Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner
2017
Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector functions, which are required for parasite control during leishmaniasis. The aim of this study was to elucidate the impact of the PD-1/PD-L axis in a human primary in vitro infection model of Leishmania major (Lm). Blocking the PD-1/PD-L interaction with nivolumab increased T-cell proliferation and release of the proinflammatory cytokines TNFα and IFNγ during the cocultivation of Lm…
The Strategy of Harm Reduction in Work with People Addicted to Drugs and Alcohol
2016
The policy of EU Member States, the United States, South America and Australia is heading towards the restructuring of the support system for addicts by implementing actions meant to limit the health and social damages resulting from the use of psychoactive substances. Many countries offer access to low-threshold programmes whereby the participant is not forced to maintain abstinence or submit to the excessive rules and obligations of a rehabilitation center. Harm reduction is a philosophy based on pragmatic and realistic goals of working with addicts and users. It assumes that each change, even the smallest, is important and should be supported. Harm reduction programmes usually function i…
La place du français dans les programmes éducatifs plurilingues en Espagne
2014
Améliorer les compétences de communication en langues étrangères est devenu l’un des éléments clé de la politique éducative de l’Europe, en réponse à l’énorme défi de la mondialisation et à l’acquisition nécessaire de nouvelles compétences professionnelles. Les programmes plurilingues en langue étrangère ont ainsi acquis une place de plus en plus importante dans notre réalité éducative. Cet article présente une réflexion sur la situation actuelle de ces programmes et montre les obstacles à franchir pour l’enseignement du français comme deuxième langue étrangère avec l’arrivée de la LOMCE (Loi Organique pour l’Amélioration de la Qualité de l’Éducation).
Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
2015
ABSTRACT Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apopto…
Uddannelse som social kunstform?
2018
Malet med denne artikel er at undersoge nogle af de kunstneriske og paedagogiske dilemmaer, der kan opsta, nar man anvender praksisstyret aktionsforskning i udviklingen af egen undervisning i og gennem de kunstneriske fag ved et universitet. Ved at fokusere pa vanskelige situationer onsker artiklen at diskutere, hvad der sker, nar laerere og studerende sammen udforsker egne roller i de utydeligt afgraensede mellemrum og spaendinger mellem praksisformerne undervisning, forskning og kunst. I forste del av artiklen praesenteres didaktiske, kunstneriske og metodiske aspekter af forskningsprojektet Art as Education/Education as Art, hvor min kollega og jeg i efteraret 2016 sammen gennemforte en …
Emerging Joint Expertise? Multiagency Collaboration Described in Local Integration Programmes in Finland
2016
Multiagency collaboration is seen as an essential way of working to promote the two-way integration of newcomers and a receiving society. The term multiagency collaboration underlines the diversity of actors in cooperation. Cross-sectorial networks are mentioned in higher strategies as well as in the local programmes or plans for action. But how is multiagency work structured at the local level? This article looks at the examples of multiagency collaboration in the written documents of local integration programmes in the Finnish context. The examples are chosen from different areas. It seems that collaboration is widely emphasized as a goal or a working method. Whereas expertise in integrat…
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Enablers and Constraints of STEM Programme Implementation: an External Change Agent Perspective from a National STEM Programme in Finland
2021
AbstractAn international need exists for effective programmes that will enhance learners’ interest in studies and careers related to science, technology, engineering and mathematics, i.e. STEM. When considering the impact of STEM programmes, it is important to identify what can enable or constrain effective programme implementation. As such, enablers can be systematically supported and constraints tackled to maximise a programme’s impact. This study considers a nationwide STEM programme in Finland that involved 450 teachers and their learning communities. The study followed an interpretative paradigm, collecting data through semi-structured interviews and analysed with data-driven thematic …
Desarrollo, territorio y capital social. Un análisis a partir de dinámicas relacionales en el desarrollo rural
2013
Si bien parece ampliamente aceptada la idea de que una de las principales fuentes de capital social son las redes sociales, llama mucho la atención la escasez de estudios que utilizan el Análisis de Redes Sociales (ARS) para profundizar en el análisis y medición del capital social. Esto es especialmente significativo si tenemos en cuenta la ingente cantidad de publicaciones que existen sobre este concepto. El propósito de este trabajo es llevar a cabo una aproximación al potencial del análisis de redes sociales (ARS) para analizar la presencia y formas de capital, en concreto, en el marco de las agrupaciones para el desarrollo rural (Grupos LEADER), y en su valor complementario a otras técn…
Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats
2007
Adolescent brain development seems to be important for the maturation of brain structures and behaviour. Intermittent binge ethanol drinking is common among adolescents, and this type of drinking can induce brain damage. Because we have demonstrated that chronic ethanol treatment induces inflammatory processes in the brain, we investigate whether intermittent ethanol intoxication enhances cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in adolescent rats, and whether these mediators induce brain damage and cause permanent cognitive dysfunctions. Adolescent rats were exposed to ethanol (3.0 g/kg) for two consecutive days at 48-h intervals over 14 days. Levels of COX-2, iN…