Search results for "pyridazine"
showing 10 items of 69 documents
Sodium-glucose cotransporter type 2 inhibitors prevent ponatinib-induced endothelial senescence and disfunction: A potential rescue strategy
2021
Background: Ponatinib (PON), a third-generation tyrosine kinase inhibitor (TKI), has proven cardiovascular toxicity, with no known preventing agents usable to limit such side effect. Sodium-glucose cotransporter type 2 (SGLT2) inhibitors are a new class of glucose-lowering agents, featuring favorable cardiac and vascular effects. Aims: We assessed the effects of the SGLT2 inhibitors empagliflozin (EMPA) and dapagliflozin (DAPA) on human aortic endothelial cells (HAECs) and underlying vasculo-protective mechanisms in an in vitro model of PON-induced endothelial toxicity. Methods and results: We exposed HAECs to PON or vehicle (DMSO) in the presence or absence of EMPA (100 and 500 nmol/L) or …
Control of Programmed Cell Death by Distinct Electrical Activity Patterns
2010
Electrical activity and sufficient supply with survival factors play a major role in the control of apoptosis in the developing cortex. Coherent high-frequency neuronal activity, which efficiently releases neurotrophins, is essential for the survival of immature neurons. We studied the influence of neuronal activity on apoptosis in the developing cortex. Dissociated cultures of the newborn mouse cerebral cortex were grown on multielectrode arrays to determine the activity patterns that promote neuronal survival. Cultures were transfected with a plasmid coding for a caspase-3-sensitive fluorescent protein allowing real-time analysis of caspase-3-dependent apoptosis in individual neurons. Ele…
A straightforward copper-free palladium methodology for the selective alkynylation of a wide variety of S-, O-, and N-based mono- and diheterocyclic …
2009
Abstract High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position -2, -3 or -5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1 mol % palladium only, with inexpensive PPh3 and amine base. The ionic liquid solvent allows a straigtforward separation of products and recycling opportunity. Unsuitable substrates and secondary reactions are also reported in order to point out further progress in cross-coupling usin…
From Mononuclear Compounds to [2 × 2] Metallogrids: Ferromagnetically Coupled Systems Built by Nickel(II) and 3,6-Bis(2′-pyridyl)pyridazine (dppn)
2020
Mono-, di-, tri-, and tetranuclear compounds of nickel(II) of formula [Ni(dppn)3](NCS)2·0.5dppn (1), [{Ni(dppn)(NCS)}2(μ-dppn)(μ-NCS)]NCS (2), [Ni3(dppn)2(N3)2(μ-dppn)2(μ-N3)2](ClO4)2·CH3CH2OH·2H2O...
ChemInform Abstract: A Straightforward Copper-Free Palladium Methodology for the Selective Alkynylation of a Wide Variety of S-, O-, and N-Based Mono…
2009
Abstract High-yield alkynylations are successfully achieved by a simple and widely accessible catalytic system for an unprecedented variety of heterocyclic bromides and chlorides in position -2, -3 or -5: pyridine, quinoline, thiophene, furan, thiazole, benzothiazole, pyrimidine, pyridazine, pyrazine, dioxepin halides are efficiently functionalized in short time reactions. This copper-free methodology employs 1 mol % palladium only, with inexpensive PPh3 and amine base. The ionic liquid solvent allows a straigtforward separation of products and recycling opportunity. Unsuitable substrates and secondary reactions are also reported in order to point out further progress in cross-coupling usin…
Synthesis of a bridgehead nitrogen system. Imidazo[1,5-b]pyridazine derivatives
1979
3,4-Dibenzoyl-2-oxobutyrate 4-semicarbazone (6a), ethyl 2,4-dioxo-3-phenacylvalerate 3-semicarbazone (6b) and diethyl phenacyloxalectate 3-semicarbazone (6c) via acid catalysed intramolecular cyclization afforded 2-phenyl-4-R-3H-imidazo[1,5-d]pyridazine-5,7-(6H)diones (8d,e,f). Elemental analyses and spectroscopic data (ir, nmr, ms) were in good agreement with the assigned structures.
CCDC 1977985: Experimental Crystal Structure Determination
2020
Related Article: Mouad Filali, El Mestafa El Hadrami, Rosaria Bruno, Giovanni De Munno, Abdeslem Bentama, Miguel Julve, Salah-Eddine Stiriba|2020|J.Mol.Struct.|1217|128420|doi:10.1016/j.molstruc.2020.128420
CCDC 1561792: Experimental Crystal Structure Determination
2017
Related Article: Tile Gieshoff, Anton Kehl, Dieter Schollmeyer, Kevin D. Moeller, Siegfried R. Waldvogel|2017|J.Am.Chem.Soc.|139|12317|doi:10.1021/jacs.7b07488
CCDC 902867: Experimental Crystal Structure Determination
2013
Related Article: T.F.Mastropietro,N.Marino,D.Armentano,G.De Munno,C.Yuste,F.Lloret,M.Julve|2013|Cryst.Growth Des.|13|270|doi:10.1021/cg301415p
CCDC 1964202: Experimental Crystal Structure Determination
2020
Related Article: Rosaria Bruno, Nadia Marino, Joan Cano, Alejandro Pascual Alvarez, Abdeslem Ben Tama, Francesc Lloret, Miguel Julve, Giovanni De Munno|2020|Cryst.Growth Des.|20|6478|doi:10.1021/acs.cgd.0c00650