Search results for "quantitative"

showing 10 items of 2409 documents

Compartmental analysis of dynamic nuclear medicine data: Models and identifiability

2016

Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the first of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an inverse problem framework. Specifically, here we discuss the identifiability problem for a general n-dimension compartmental system and provide uniqueness results in the case of two-compartment and three-compartment compartmental models. The second paper will utilize this framework in order to show how non-linear regularization schemes can be applied t…

Regularization (mathematics)Quantitative Biology - Quantitative Methods030218 nuclear medicine & medical imagingTheoretical Computer ScienceData modeling03 medical and health sciences0302 clinical medicinecompartmental analysis; identifiability; nuclear medicine dataTRACERFOS: Mathematicscompartmental analysisUniquenessMathematics - Numerical AnalysisMathematical PhysicsQuantitative Methods (q-bio.QM)Mathematicsbusiness.industryApplied MathematicsBiological tissueNumerical Analysis (math.NA)Inverse problemidentifiabilityComputer Science ApplicationsNonlinear systemnuclear medicine dataFOS: Biological sciencesSignal ProcessingIdentifiabilityNuclear medicinebusiness030217 neurology & neurosurgery
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A novel numerical meshless approach for electric potential estimation in transcranial stimulation

2015

In this paper, a first application of the method of fundamental solutions in estimating the electric potential and the spatial current density distribution in the brain due to transcranial stimulation, is presented. The coupled boundary value p roblems for the electric potential are solved in a meshless way, so avoiding the use of grid based numerical methods. A multi-spherical geometry is considered and numerical results are discussed.

Regularized meshless methodMathematical optimizationmethod of fundamental solutionQuantitative Biology::Neurons and CognitionNumerical analysistranscranial electrical stimulationCurrent density distributionGrid basedBoundary valuesPhysics and Astronomy (all)Settore MAT/08 - Analisi NumericaSettore ING-IND/31 - ElettrotecnicaApplied mathematicsMethod of fundamental solutionsMeshfree methodsmeshless methodElectric potentialnumerical approximationMathematics
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University campuses as small-scale models of cities: Quantitative assessment of a low carbon transition path

2019

Abstract The energy efficiency interventions and rehabilitation actions regarding university campuses are characterized by an emblematic impact, representing significant examples of good practices that a given community could adopt, even at the city level. Starting from the idea that campuses may be regarded as small scale models of cities, a quantitative method for estimating to which extent the adoption of a given set of interventions by a municipality could contribute to make such city close to a nearly zero energy profile is proposed. To accomplish this task, the study considers the low carbon transition path of the campus of the University of Palermo and applies a simple method that, i…

Renewable Energy Sustainability and the Environmentbusiness.industryComputer science020209 energyPsychological intervention02 engineering and technologyEnvironmental economicsEnergy policyProcurementPublic transport0202 electrical engineering electronic engineering information engineeringQuantitative assessmentbusinessScale modelStock (geology)Efficient energy useRenewable and Sustainable Energy Reviews
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Determination of acetazolamide in human urine samples by reversed-phase high-performance liquid chromatography in the presence of xanthines.

1992

A simple, rapid and selective high-performance liquid chromatographic assay for the determination of acetazolamide in urine samples is described. After extraction with ethyl acetate, the drug is chromatographed on an HP-Hypersil ODS-C18 column with a mobile phase of acetonitrile-phosphate buffer (pH 3) and ultraviolet detection at 275 nm. The efficiency of the extraction, the linearity and the reproducibility of the method permit the evaluation of acetazolamide urinary excretion a long time after its administration.

ReproducibilityChromatographyChemistryExtraction (chemistry)Ethyl acetateGeneral ChemistryReversed-phase chromatographyUrineHigh-performance liquid chromatographyAcetazolamidechemistry.chemical_compoundXanthinesmedicineHumansAcetazolamideDrug ContaminationQuantitative analysis (chemistry)Chromatography High Pressure Liquidmedicine.drugJournal of chromatography
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Duplexsonographie der normalen Pfortader

2008

In 50 normal subjects flow velocity and direction on the portal vein was measured by ultrasonic duplex system. The measurements revealed at a mean diameter of 9.7 mm, a mean flow velocity of 15.2 +/- 2.6 cm/s, corresponding to a volume flow of 693 +/- 235 ml/min. Postprandially this increased to 880 +/- 269 ml/min. Inter-observer and day to day measurements demonstrated good reproducibility. Thus, this simple non-invasive method is well suited for quantitative assessment of the portal vein system in portal hypertension, thrombosis or after shunt operations.

ReproducibilityMaterials sciencebusiness.industryPortal veinGeneral Medicinemedicine.diseaseThrombosisFlow velocitymedicineDuplex sonographyQuantitative assessmentPortal hypertensionNuclear medicinebusinessShunt (electrical)DMW - Deutsche Medizinische Wochenschrift
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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La RSE dansles entreprises de la région BFC,des pratiques paradoxales

2022

Cette étude statistique s’intéresse aux pratiques de RSE des entreprises de petite taille de la région Bourgogne Franche Comté (BFC), étant donné que ces dernières sont quasi délaissées par la recherche scientifique au profit des grandes entreprises comme démontré par Oueghlissi (2013). Le choix de la région BFC s’explique par l’accès facilité au terrain et le fait que la RSE est à ce jour peu explorée d’un point de vue académique dans cette région. Elle met en avant plusieurs paradoxes que nous présentons dans cette étude.

Responsabilité sociétale de l’entreprise RSEAnalyse quantitativeStatistiques descriptives[QFIN] Quantitative Finance [q-fin]
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Factors affecting Finnish consumers' intention to receive SMS marketing: a conceptual model and an empirical study

2008

The study examines factors that affect consumers' intentions to participate in mobile marketing and explores the relationship between consumers' intentions to participate in mobile marketing and their experience with mobile marketing. The authors develop and test a research model with a sample of 4062 mobile phone users. The empirical model highlights that Perceived Utility (PU), context, credibility and Perceived Social Utility (PSU) are the main contributors to consumers' intentions to participate in mobile-marketing initiatives. The paper provides several contributions to both theory and practice.

Return on marketing investmentDigital marketingbusiness.industryAdvertisingQuantitative marketing researchGeneral Business Management and AccountingComputer Science ApplicationsEmpirical researchMobile phoneCredibilityMarketingbusinessMarketing researchRelationship marketingInternational Journal of Electronic Business
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The Opportunities of Relationship Marketing: Aspect of the Eu Digital Market

2016

The purpose of research is to analyse and evaluate opportunities of using relationship marketing in online trading. The objectives of research are to analyse scientific literature on the topic, to conduct a relationship marketing research, to make the internet trade industry analysis, to evaluate opportunities of using relationship marketing in online trading. The methods of research are: theoretical analysis of scientific literature, experts’ survey and its statistical analysis. In the course of time it becomes necessary to have long-term relationships between businesses and consumers. Many companies want not only to sell their products to the consumer just once, but also to make up a new …

Return on marketing investmentDigital marketingbusiness.industryMarketing effectiveness05 social sciencesArts & HumanitiesQuantitative marketing researchMarketing strategyMarketing managementBusiness marketing0502 economics and business050211 marketingBusinessMarketingMarketing research050203 business & managementEuropean Integration Studies: Research and Topicalities
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Marketing communication metrics for social media

2011

The objective of this paper is to develop a conceptual framework for measuring the effectiveness of social media marketing communications. Specifically, we study whether the existing marketing communications performance metrics are still valid in the changing digitalised communications landscape, or whether it is time to rethink them, or even to devise entirely new metrics. Recent advances in information technology and marketing bring a need to re-examine measurement models. We combine two important research topics and set directions for potential future research. Metrics to measure marketing communications performance have developed towards a customer orientation. There is no broadly accep…

Return on marketing investmentKnowledge managementmarkkinoinnin tehokkuuden mittaaminenComputer sciencesocial media marketingQuantitative marketing researchmarkkinointiviestintäMarketing scienceMarketing managementsosiaaliset verkostotqualitative metricsmarketing communications marketing performanceMarketingMarketing researchRelationship marketingMarketingfinancial metricsDigital marketingbusiness.industryperformance measurementquantitative metricsMarketing strategyComputer Science Applicationssocial networks.laadullinen mittaaminenbusinessInternational Journal of Technology Marketing
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