Search results for "quantitative"
showing 10 items of 2409 documents
Adaptive linear rank tests for eQTL studies
2012
Expression quantitative trait loci (eQTL) studies are performed to identify single-nucleotide polymorphisms that modify average expression values of genes, proteins, or metabolites, depending on the genotype. As expression values are often not normally distributed, statistical methods for eQTL studies should be valid and powerful in these situations. Adaptive tests are promising alternatives to standard approaches, such as the analysis of variance or the Kruskal-Wallis test. In a two-stage procedure, skewness and tail length of the distributions are estimated and used to select one of several linear rank tests. In this study, we compare two adaptive tests that were proposed in the literatur…
Immune networks: multitasking capabilities near saturation
2013
Pattern-diluted associative networks were introduced recently as models for the immune system, with nodes representing T-lymphocytes and stored patterns representing signalling protocols between T- and B-lymphocytes. It was shown earlier that in the regime of extreme pattern dilution, a system with $N_T$ T-lymphocytes can manage a number $N_B!=!\order(N_T^\delta)$ of B-lymphocytes simultaneously, with $\delta!<!1$. Here we study this model in the extensive load regime $N_B!=!\alpha N_T$, with also a high degree of pattern dilution, in agreement with immunological findings. We use graph theory and statistical mechanical analysis based on replica methods to show that in the finite-connectivit…
Wardowski conditions to the coincidence problem
2015
In this article we first discuss the existence and uniqueness of a solution for the coincidence problem: Find p ∈ X such that Tp = Sp, where X is a nonempty set, Y is a complete metric space, and T, S:X → Y are two mappings satisfying a Wardowski type condition of contractivity. Later on, we will state the convergence of the Picard-Juncgk iteration process to the above coincidence problem as well as a rate of convergence for this iteration scheme. Finally, we shall apply our results to study the existence and uniqueness of a solution as well as the convergence of the Picard-Juncgk iteration process toward the solution of a second order differential equation. Ministerio de Economía y Competi…
Stability of a stochastic SIR system
2005
Abstract We propose a stochastic SIR model with or without distributed time delay and we study the stability of disease-free equilibrium. The numerical simulation of the stochastic SIR model shows that the introduction of noise modifies the threshold of system for an epidemic to occur and the threshold stochastic value is found.
Splitting the dynamics of large biochemical interaction networks
2003
This article is inscribed in the general motivation of understanding the dynamics on biochemical networks including metabolic and genetic interactions. Our approach is continuous modeling by differential equations. We address the problem of the huge size of those systems. We present a mathematical tool for reducing the size of the model, master-slave synchronization, and fit it to the biochemical context.
Distribution of oxygen partial pressure in a two-dimensional tissue supplied by capillary meshes and concurrent and countercurrent systems
1969
Abstract For the calculations of oxygen partial pressure in a two-dimensional tissue model supplied by a capillary network (inhomogeneously perfused tissue), two differential equations are given that describe the process in the tissue and capillaries. The differential equations are coupled by the boundary conditions. Results obtained by using the method of successive displacements are given for the two-dimensional problem. This method exhibits a satisfactory convergence. The accuracy of the results is about ±5% based on the initial concentration. The results for the network model are compared with those for equivalent concurrent and countercurrent systems. Equivalence means in this connecti…
Multivariate GARCH estimation via a Bregman-proximal trust-region method
2011
The estimation of multivariate GARCH time series models is a difficult task mainly due to the significant overparameterization exhibited by the problem and usually referred to as the "curse of dimensionality". For example, in the case of the VEC family, the number of parameters involved in the model grows as a polynomial of order four on the dimensionality of the problem. Moreover, these parameters are subjected to convoluted nonlinear constraints necessary to ensure, for instance, the existence of stationary solutions and the positive semidefinite character of the conditional covariance matrices used in the model design. So far, this problem has been addressed in the literature only in low…
Calibration of optimal execution of financial transactions in the presence of transient market impact
2012
Trading large volumes of a financial asset in order driven markets requires the use of algorithmic execution dividing the volume in many transactions in order to minimize costs due to market impact. A proper design of an optimal execution strategy strongly depends on a careful modeling of market impact, i.e. how the price reacts to trades. In this paper we consider a recently introduced market impact model (Bouchaud et al., 2004), which has the property of describing both the volume and the temporal dependence of price change due to trading. We show how this model can be used to describe price impact also in aggregated trade time or in real time. We then solve analytically and calibrate wit…
On a set of data for the membrane potential in a neuron
2006
We consider a set of data where the membrane potential in a pyramidal neuron is measured almost continuously in time, under varying experimental conditions. We use nonparametric estimates for the diffusion coefficient and the drift in view to contribute to the discussion which type of diffusion process is suitable to model the membrane potential in a neuron (more exactly: in a particular type of neuron under particular experimental conditions).
Immune networks: Multi-tasking capabilities at medium load
2013
Associative network models featuring multi-tasking properties have been introduced recently and studied in the low load regime, where the number $P$ of simultaneously retrievable patterns scales with the number $N$ of nodes as $P\sim \log N$. In addition to their relevance in artificial intelligence, these models are increasingly important in immunology, where stored patterns represent strategies to fight pathogens and nodes represent lymphocyte clones. They allow us to understand the crucial ability of the immune system to respond simultaneously to multiple distinct antigen invasions. Here we develop further the statistical mechanical analysis of such systems, by studying the medium load r…