Search results for "quest"
showing 10 items of 3700 documents
Dottore, mio figlio non impara a leggere”. I Disturbi Specifici dell’Apprendimento (DSA) e il pediatra di famiglia
2015
Si parla di Disturbo Specifico di Apprendimento (DSA) quando sono presenti delle difficoltà isolate e circoscritte nella lettura (Dislessia) e/o nella scrittura (Disortografia) e/o nel calcolo (Discalculia) nonostante la presenza di adeguate capacità cognitive e opportunità scolastiche. Tali difficoltà hanno carattere evolutivo e persistente, presentandosi con diversa espressività clinica nelle varie fasi dello sviluppo. La prevalenza mondiale del disturbo si attesta tra il 5 e il 15% (DSM 5, 2013). L’incidenza è maggiore nei maschi, con un rapporto M/F stimato intorno a 2:1, 3:1 (DSM 5, 2013). In Italia la stima di prevalenza dei DSA fra i bambini in età scolare oscilla fra il 3 e il 5% (C…
Urethroplasty with dorsal buccal mucosa graft. Is it still the method of choice in long term urethral stenosis?
2017
The aim of our work was to evaluate the long-term changes in symptoms (median 42 months) and to analyze data for any negative predictive factors for the application of the procedure, in patients who underwent to urethroplasty with dorsal buccal mucosa graft. During the period from 2010 to 2015 27 patients were examined. Than they underwent urethroplasty using dorsal buccal mucosa graft (graft of 4 x 2.5 cm). The evaluation of symptoms has been addressed through the application of the IPSS Quality of Life Questionnaire (International Prostatic Symptoms Score) and the evaluation of urinary flow has been carried out by a comparative analysis between the pre- and post-operative uroflowmetry. As…
The hallmark of anonymity. Questions of authorship in the Hippocratic Corpus, specifically regarding the so-called 'Author C'
2020
Since Émile Littrés’ time a particular attention has been devoted to a group of Hippocratic treatises (On Generation/On the Nature of the Child + Book IV of Diseases) showing a significant range of affinities and common elements in language, style, tenor and thought. Studies by Hermann Grensemann (in the 1980s) contributed to further philological analysis of the peculiar traits of the so-called Hippocratic ‘author C’, widening the textual basis to be involved in the investigation (including gynaecological treatises like On Diseases of Women 1-2 as well as parts of Infertile Women). Recently new light has also been shed by Elizabeth Craik (editing 2009 the treatise On Glands) on the historic…
Contribution à l'étude des évolutions contemporaines du droit constitutionnel français
2016
Classiquement consacré à l’étude des institutions politiques, le droit constitutionnel s’est enrichi de l’étude du système normatif, notamment dans ses liens avec les systèmes juridiques régionaux et internationaux, et de la protection des droits et libertés fondamentaux. Les travaux de recherche présentés dans ce mémoire ne portent pas sur l’étude des institutions politiques mais intéressent en revanche les deux autres domaines du droit constitutionnel.S’agissant de l’étude du système normatif, il apparaît qu’il s’ajuste progressivement pour mieux intégrer les contraintes liées au développement du droit international en général et du droit de l’Union européenne et de la Convention européen…
A survey on IVIVC/IVIVR development in the pharmaceutical industry – Past experience and current perspectives
2017
The present work aimed to describe the current status of IVIVC/IVIVR development in the pharmaceutical industry, focusing on the use and perception of specific approaches as well as successful and failed case studies. Two questionnaires have been distributed to 13 EFPIA partners of the Oral Biopharmaceutics Tools Initiative and to the Pharmacokinetics Working Party of the European Medicines Agency in order to capture the perspectives and experiences of industry scientists and agency members, respectively. Responses from ten companies and three European Agencies were received between May 21st 2014 and January 19th 2016. The majority of the companies acknowledged the importance of IVIVC/IVIVR…
Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.
2015
Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerström tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu 1 (OPRM1) gene, using a TaqMan® protocol. …
Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences
2017
Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol. Hence, in the last years, several pre-clinical studies have been performed in order to analyze the effects of the sequestering ACD agents in the prevention of ethano…
The use of dry needling to treat painful shoulder syndrome: a case report
2020
Background. Painful shoulder syndrome is a common condition in society. Most patients experience pain and reduced mobility of the affected limb, which can have an impact on the quality of life. This report presents a case of a patient with pain and reduced range of motion in the left shoulder. Aim of the study. The study aim was to evaluate the efficacy of dry needling in the treatment of painful shoulder syndrome, based on functional measures of pain, disability and range of motion. Case report. A 42-year old patient reported pain in her left shoulder. A series of 6 dry needling sessions were performed, twice a week, for a period of 3 weeks. Prior to, and immediately after, the therapy a s…
Consenso Delphi sobre el diagnóstico y manejo de la dislipidemia en pacientes con enfermedad renal crónica: análisis post-hoc del estudio DIANA
2016
Resumen Antecedentes y objetivos: Este estudio post hoc analizó la percepción de la importancia de la enfermedad renal crónica (ERC) en el cribado de la dislipidemia y en la elección del tratamiento con estatinas entre médicos de Atención Primaria (MAP) y otras especialidades mediante cuestionario Delphi. Métodos: El cuestionario incluyó 4 bloques de preguntas alrededor del paciente dislipémico con alteración del metabolismo hidrocarbonado. Aquí se presentan los resultados relacionados con la consideración de la ERC en el cribado y la elección de la estatina. Resultados: De los 497 expertos incluidos, el 58% eran MAP y el 42%, especialistas (35, el 7%, nefrólogos). Hubo consenso en realizar…
Rejet d'une QPC relative au régime de la revendication des biens issu de l'ordonnance du 18 décembre 2008
2011
International audience; (Com., 15 mars 2011, n° 10-40.073, arrêt n° 374 FS-P+B, Sté Eurosak France c/ M. Verrecchia ès qual., D. 2011. 815, obs. A. Lienhard)