Search results for "quest"

showing 10 items of 3700 documents

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

2014

Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…

GTPase-activating proteinlipid dropletsrab3 GTP-Binding ProteinsATG16L1DMSO dimethyl sulfoxideFEZ20302 clinical medicineATG autophagy-relatedPhagosomesDAPI 4’ 6-diamidino-2-phenylindoleSQSTM1 sequestosome 1ATG16L1MAP1LC3 microtubule-associated protein 1 light chain 3GFP green fluorescent protein0303 health sciencesGABARAP GABA(A) receptor-associated proteinGTPase-Activating ProteinsCell biologyRAB3GAP1RAB3GAP2RABGAP RAB GTPase activating proteinATG3autophagyCALCOCO2 calcium binding and coiled-coil domain 2Basic Research PaperseV empty vectorATG8ATG5PBS phosphate-buffered salineBiologyPE phosphatidylethanolamineTBC domain TRE2-BUB2-CDC16 domainBAG3GEF guanine nucleotide exchange factor03 medical and health sciencesC. elegans Caenorhabditis elegansAnimalsHumansCaenorhabditis elegansMolecular Biology030304 developmental biologySirolimusDPH 1 6-diphenyl-1 3 5-hexatrieneproteostasisAutophagyBiological TransportCell BiologyFEZ1Bafi bafilomycin A1FEZ fasciculation and elongation protein zetaNBR1 neighbor of BRCA1 gene 1ProteostasissiRNA small interfering RNABSA bovine serum albuminRabLysosomes030217 neurology & neurosurgeryAutophagy
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Parliaments and the Rhetorical Languages of Politics

2005

Gender StudiesHistoryPoliticsSociology and Political ScienceLawPolitical scienceRhetorical questionlcsh:JC11-607lcsh:Women. Feminismlcsh:Political theorylcsh:HQ1101-2030.7Redescriptions: Political Thought, Conceptual History and Feminist Theory
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El conocimiento pedagógico y la periferia del universo educativo

2006

In this work the authors reflect on the dynamics generated between the universe of education and educational theory, as the fruit of the incorporation to that universe of areas and forms which up until then had been external, borderline or marginal to it. After an introduction, the article applies this general perspective to diverse spheres: in the fi rst place, to what the consideration of non-formal and formal education has meant for educational theory; in second place, the same is done with respect to the idea of permanent education; third, it is applied to the repercussions that the real recognition of gender equality in education has on pedagogical discourse; fourth, to what the possib…

Gender equalitylcsh:LC8-6691lcsh:Special aspects of educationEmerging technologiesEducation theoryPerspective (graphical)General Medicinelcsh:Education (General)EpistemologyFormal educationDynamics (music)Rhetorical questionSociologySocial sciencelcsh:L7-991
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Evidence for shared environmental contributions to attention-deficit/hyperactivity traits. A twin study

2019

Background and objectives: Behavior-genetic analyses have shown that measurements of inattention and hyperactivity-impulsivity are genetically-influenced. In view of limited studies on ADHD (Attention deficit hyperactivity disorder) in Spanish samples, this study aims to explore the genetic architecture of ADHD symptoms; inattention and hyperactivity-impulsivity in a Spanish twin schoolchildren sample. Methods: Participants were 258 pairs of adolescent Spanish twins. Symptoms of ADHD, inattention and hyperactivity-impulsivity were assessed by means of a sub-scale of the Strengths and Difficulties Questionnaire. Univariate twin models, according to sex, were run to assess the heritability of…

Gender/gender differencesCultural valuesStrengths and Difficulties QuestionnaireHeritabilitymedicine.diseaseTwin studyGenetic architecture030227 psychiatry03 medical and health sciencesPsychiatry and Mental health0302 clinical medicineBehavior geneticsmedicineAttention deficitAttention deficit hyperactivity disorderMental health030212 general & internal medicineAdhd symptomsPsychologyClinical psychology
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Qualities of mathematical discourses in kindergartens

2020

AbstractIn this study we investigated qualities of the mathematical discourse in four kindergarten classes in which kindergarten teachers and 5-year-old children engaged in mathematical learning activities. We analysed differences in the mathematical discourses in two experimental kindergarten classes and two control kindergarten classes, in a research and development project. The overarching research question guiding our study was as follows: what characterises the mathematical discourse unfolding in kindergarten classes? In our study we drew on the theoretical framework Mathematical Discourse in Instruction coined by Adler and Ronda, as we quantified the collected qualitative data. Our an…

General MathematicsDiscourse analysisTeaching methodMathematics educationMathematical learningQualitative propertyMathematical discourseMathematics instructionPsychologyControl (linguistics)VDP::Matematikk og Naturvitenskap: 400::Matematikk: 410Research questionEducationZDM
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What seems to be the problem?—A study of connections between national contexts and regional e-health strategies

2015

Abstract Motivation Different e-health strategies may produce different long-term results, so it is of general interest to look into strategies behind e-health approaches, and what factors that influence strategy-formation. Problem statement Previous studies into process improvements in the e-health area has suggested that approaches and strategies are very dependent on national contexts. This study explores this issue, by sampling two national regions in Europe, the St. Gallen region and canton in Switzerland, and the Agder region comprised of the two Agder-counties, in Norway. The research questions revolve around the extent to which the context influences e-health innovation in two diffe…

General interestbusiness.industryProcess (engineering)Health PolicyBiomedical EngineeringProblem statementContext (language use)Public relationsResearch communityResearch questionsSociologyMarketingService innovationbusinessLevel of analysisHealth Policy and Technology
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Knowledge, Attitudes, and Smoking Behaviours among Physicians Specializing in Public Health: A Multicentre Study

2014

Background. Healthcare professionals have an important role to play both as advisers—influencing smoking cessation—and as role models. However, many of them continue to smoke. The aims of this study were to examine smoking prevalence, knowledge, attitudes, and behaviours among four cohorts physicians specializing in public health, according to the Global Health Profession Students Survey (GHPSS) approach.Materials and Methods. A multicentre cross-sectional study was carried out in 24 Italian schools of public health. The survey was conducted between January and April 2012 and it was carried out a census of students in the selected schools for each years of course (from first to fourth year …

Genetics and Molecular Biology (all)MaleHealth Knowledge Attitudes PracticeMEDICAL-STUDENTSImmunology and Microbiology (all)Cross-sectional studymedicine.medical_treatmentlcsh:MedicinecurriculumSettore MED/42 - Igiene Generale E ApplicataBiochemistryGHPSS questionnairehealth behaviorPROFESSIONS STUDENT SURVEY; TOBACCO USE; MEDICAL-STUDENTS; CESSATION; DEPENDENCE; SCHOOLS; GHPSSDEPENDENCESurveys and QuestionnairesGlobal healthSurveys and Questionnairesmoking behaviourMedicine (all)SmokingAttendanceTOBACCO USEGeneral MedicineMiddle Agedcohort analysismulticentre studyTest (assessment)femalesmoking; prevention.; public healthPublic Healthhealth care personneGHPSSResearch ArticleHumanCohort studyAdultmedicine.medical_specialtyArticle SubjectAttitude of Health PersonneleducationBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all); Medicine (all)General Biochemistry Genetics and Molecular BiologySCHOOLScohort analysis; controlled study; cross-sectional study; curriculum; female; GHPSS questionnaire; health behavior; health care personnemedicineHumanscross-sectional studycontrolled studyCurriculumBiochemistry Genetics and Molecular Biology (all)General Immunology and Microbiologybusiness.industryPublic healthlcsh:RFamily medicineSmoking cessationSmoking CessationPROFESSIONS STUDENT SURVEYCESSATIONbusinessBioMed Research International
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Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: A multicenter case-control study in Italy

2018

Background Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as hypertension, cholesterol, ever smoker, BMI> 25, diabetes, has not been deeply studied. Design Case-control study. Methods Patients with first AMI and controls from four tertiary referral Italian centers were screened for enrolment. Dietary information was collected through a questionnaire and a MD adherence score was calculated. Physical activity and smoking habits were also registered. The Synergy Index was calculated according to Rothman…

Genetics and Molecular Biology (all)MaleMultivariate analysisMediterranean dietTertiary Care CenterMyocardial Infarctionlcsh:MedicineBlood PressureMediterranean030204 cardiovascular system & hematologyPathology and Laboratory MedicineDiet MediterraneanVascular MedicineBiochemistryGeographical locationsTertiary Care CentersHabitschemistry.chemical_compoundEndocrinology0302 clinical medicineRisk FactorsSurveys and QuestionnairesMedicine and Health SciencesSmoking HabitsSurveys and Questionnaire030212 general & internal medicineMyocardial infarctionlcsh:ScienceMultidisciplinarySmokingMiddle AgedEuropeHyperlipidemiaItalyResearch DesignSettore MED/42HypertensionFemaleCase-Control StudieHumanResearch Articlemedicine.medical_specialtyAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient ComplianceReferralEndocrine DisordersSmoking habitHypercholesterolemiaCardiologyResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicineDiabetes mellitusInternal medicineDiabetes MellitusAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient Compliance; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)medicineHumansEuropean UnionNutritionAgedBehaviorCholesterolbusiness.industryRisk Factorlcsh:RCase-control studyBiology and Life SciencesFeeding Behaviormedicine.diseaseDietAgricultural and Biological Sciences (all)chemistryMetabolic DisordersCase-Control StudiesPatient Compliancelcsh:QPeople and placesbusinessPLOS ONE
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Factors influencing psychological well-being in patients with Parkinson's disease.

2017

Background Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. Objectives To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. Methods This article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relatio…

Genetics and Molecular Biology (all)MaleParkinson's diseaseEmotionsPoison controlSocial Scienceslcsh:MedicinePathology and Laboratory MedicineBiochemistrySeverity of Illness IndexAged; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)0302 clinical medicineMathematical and Statistical TechniquesQuality of lifeSurveys and QuestionnairesMedicine and Health SciencesMedicinePsychologySurveys and Questionnaire030212 general & internal medicinelcsh:ScienceDepression (differential diagnoses)FatigueMultidisciplinaryMovement DisordersDepressionNeurodegenerative DiseasesParkinson DiseaseMiddle AgedPsychiatric Status Rating ScalehumanitiesNeurologyItalyPhysical SciencesFemaleStatistics (Mathematics)Clinical psychologyResearch ArticleHumanResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicineSeverity of illnessInjury preventionMental Health and PsychiatryHumansStatistical MethodsAgedPsychiatric Status Rating Scalesparkinson's disease quality of lifeAnalysis of VarianceBiochemistry Genetics and Molecular Biology (all)business.industryMood Disorderslcsh:RBeck Depression InventoryBiology and Life Sciencesmedicine.diseaseHealth CareAgricultural and Biological Sciences (all)Psychological well-beingAged; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Quality of Life; Severity of Illness Index; Surveys and QuestionnairesQuality of Lifelcsh:QbusinessSleep Disorders030217 neurology & neurosurgeryMathematicsPLoS ONE
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Inter-Relations among Motivation, Self-Perceived Use of Strategies and Academic Achievement in Science: A Study with Spanish Secondary School Students

2020

The relationship between motivation and the use of learning strategies is a focus of research in order to improve students&rsquo

Geography Planning and DevelopmentStepwise regression analysisMetacognitionTJ807-830Academic achievementManagement Monitoring Policy and LawTD194-195050105 experimental psychologyMotivació en l'educacióRenewable energy sourcesMeaningful learningmotivationAprenentatgeMathematics educationComputingMilieux_COMPUTERSANDEDUCATIONSelf perceived0501 psychology and cognitive sciencesResource managementGE1-350learning strategiesEnvironmental effects of industries and plantsRenewable Energy Sustainability and the Environment05 social sciencesscience learning achievement050301 educationCognitionBuilding and ConstructionLearning sciencesEnvironmental sciencesMSLQ questionnaireEducació secundàriasecondary school studentsPsychology0503 educationSustainability
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