Search results for "raft"

Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach

2021

(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. (2) Methods: DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochemical yields of various…

Optimal airline seat inventory control for multi‐leg flights

2004

Airline seat inventory control is about “selling the right seats to the right people at the right time”. In this paper, the problem of determining optimal booking policy for multiple fare classes in a pool of identical seats for multi‐leg flights is considered. During the time prior to departure of a multi‐leg flight, decisions must be made concerning the allocation of reserved seats to passengers requesting space on the full or partial spans of the flight. It will be noted that in the case of multi‐leg flights the long‐haul passengers are often unable to obtain seats because the shorter‐haul passengers block them. For large commercial airlines, efficiently setting and updating seat allocat…

Varieties of Codes and Kraft Inequality

2007

Decipherability conditions for codes are investigated by using the approach of Guzman, who introduced in [7] the notion of variety of codes and established a connection between classes of codes and varieties of monoids. The class of Uniquely Decipherable (UD) codes is a special case of variety of codes, corresponding to the variety of all monoids. It is well known that the Kraft inequality is a necessary condition for UD codes, but it is not sufficient, in the sense that there exist codes that are not UD and that satisfy the Kraft inequality. The main result of the present paper states that, given a variety V of codes, if all the elements of V satisfy the Kraft inequality, then V is the var…

Varieties of Codes and Kraft Inequality

2005

Decipherability conditions for codes are investigated by using the approach of Guzman, who introduced in [7] the notion of variety of codes and established a connection between classes of codes and varieties of monoids. The class of Uniquely Decipherable (UD) codes is a special case of variety of codes, corresponding to the variety of all monoids. It is well known that the Kraft inequality is a necessary condition for UD codes, but it is not sufficient, in the sense that there exist codes that are not UD and that satisfy the Kraft inequality. The main result of the present paper states that, given a variety $\mathcal{V}$ of codes, if all the elements of $\mathcal{V}$ satisfy the Kraft inequ…

An empirically grounded agent based model for modeling directs, conflict detection and resolution operations in air traffic management

2017

We present an agent based model of the Air Traffic Management socio-technical complex system that aims at modeling the interactions between aircrafts and air traffic controllers at a tactical level. The core of the model is given by the conflict detection and resolution module and by the directs module. Directs are flight shortcuts that are given by air controllers to speed up the passage of an aircraft within a certain airspace and therefore to facilitate airline operations. Conflicts resolution between flight trajectories can arise during the en-route phase of each flight due to both not detailed flight trajectory planning or unforeseen events that perturb the planned flight plan. Our mod…

In-situ forming gel-like depot of a polyaspartamide-polylactide copolymer for once a week administration of Sulpiride

2015

Abstract Objectives An in-situ forming gel-like depot, prepared by using an appropriate polyaspartamide-polylactide graft copolymer, has been employed to release in a sustained way sulpiride. Methods α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide-g-polylactic acid (PHEA-g-PLA) has been used as a polymer component. Its physicochemical properties make possible to dissolve it in N-methyl-2-pyrrolidone, with the obtainment of a solution able to form a gel-like depot once injected into a physiological medium. Cell compatibility of PHEA-g-PLA depot has been investigated, using murine dermal fibroblasts as cell model. 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazo…

Injectable in situ forming microgels of hyaluronic acid-g-polylactic acid for methylprednisolone release

2013

Abstract A hydrophobic derivative of hyaluronic acid (HA), obtained by grafting polylactic acid (PLA) to the polysaccharide, has been exploited to produce injectable in situ forming microgels. First of all, self assembling properties of HA-g-PLA copolymer have been evaluated by determining the critical aggregation concentration (CAC) value, then this copolymer has been dissolved in a mixture water/NMP 5:2 v/v with a concentration greater than CAC. When solutions at 1% or 2% w/v were injected into Dulbecco phosphate buffer solution (DPBS) pH 7.4, microgels promptly are formed. Their stability in DPBS pH 7.4 in the absence or in the presence of hyaluronidase and cell compatibility have been e…

Dual-Source Computed Tomography (DSCT) Angiography for the Visualization of Coronary Artery Bypass Grafts (CABG)

2007

Trace gas composition in the Asian summer monsoon anticyclone: a case study based on aircraft observations and model simulations

2017

We present in situ measurements of the trace gas composition of the upper tropospheric (UT) Asian summer monsoon anticyclone (ASMA) performed with the High Altitude and Long Range Research Aircraft (HALO) in the frame of the Earth System Model Validation (ESMVal) campaign. Air masses with enhanced O3 mixing ratios were encountered after entering the ASMA at its southern edge at about 150 hPa on 18 September 2012. This is in contrast to the presumption that the anticyclone's interior is dominated by recently uplifted air with low O3 in the monsoon season. We also observed enhanced CO and HCl in the ASMA, which are tracers for boundary layer pollution and tropopause layer (TL) air or stratosp…

Approximation of Measurement Results of “Emergency” Signal Reception Probability

2017

Abstract The intended aim of this article is to present approximation results of the exemplary measurements of EMERGENCY signal reception probability. The probability is under-stood as a distance function between the aircraft and a ground-based system under established conditions. The measurements were approximated using the properties of logistic functions. This probability, as a distance function, enables to determine the range of the EMERGENCY signal for a pre-set confidence level.