Search results for "regulation"

Effects of Difficulty in Handling Emotions and Social Interactions on Nomophobia: Examining the Mediating Role of Feelings of Loneliness

2022

Abstract This study was addressed to assess nomophobia in an Italian sample (N = 456, 53.1% men, Mage = 31.8, SD = 11.1), also providing a deeper knowledge about how it is distributed across demographics, as well as identifying its best predictors. The main goal was to investigate the direct and indirect effects of difficulty in emotion regulation and social interaction anxiety on nomophobia through loneliness. Our findings indicated that loneliness explained the effect of the expressive suppression strategy (fully) and social interaction anxiety (partially) on nomophobia, whereas it was not a significant mediator when the cognitive reappraisal strategy was taken into account. Our study sug…

The regulation of emotions: Gender differences

2021

IntroductionEmotional regulation, understood as the emotional ability to repair emotional states, is a skill closely linked to adaptation during aging. People who are capable to manage their emotions have greater control over moods, applying adaptive regulation strategies that allow them to maintain positive moods and modify or regulate negative ones. It has been observed that gender can be a relevant variable related to emotional regulation. In this sense, it is considered that women may be more skillful than men to emotional regulation strategies, benefiting from more successful emotional management strategies.ObjectivesVerify if there are differences in the ability of emotional regulatio…

A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability qu…

2021

Abstract Background The failure to regulate emotions, namely emotional dysregulation (ED), is a relevant construct in adolescent psychiatry, in terms of prognostic and developmental implications. We developed and validated a novel self-report questionnaire for the assessment of ED, the RIPoSt-Y, both in clinical and non-clinical samples. Methods Items selection and subscales construction were conducted on healthy controls (n=374), while test-retest reliability was evaluated in a subsample (n=72); internal consistency was examined both in the control group and in two clinical samples, respectively including patients with Bipolar Spectrum Disorders (BSD; n=44) and ADHD (n=34). Construct, conc…

The effect of resonance frequency breathing when used as a preparatory exercise in music psychotherapy : A single-case experimental study of a client…

2017

This study aimed at evaluating the possible benefits of starting Integrative Improvisational Music Therapy (IIMT) sessions with 10 min of Resonance Frequency Breathing (RFB), a type of slow breathing known to be beneficial for stress reduction and emotional regulation. A client diagnosed with anxiety disorder and social phobia attended 12 IIMT sessions. Using an alternating treatments design, RFB was systematically alternated with a control intervention (vibroacoustic therapy, VAT). Therapy processes were assessed through the Session Evaluation Questionnaire (SEQ) and the continuous measurement of heart rate variability (HRV), a biomarker of autonomic nervous system response. RFB was consis…

COVID-19 and tuberculosis - threats and opportunities

2020

Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mR…

1999

Alveolar macrophages (AM) play a decisive role in the immunologic defense system of the lung and in inflammatory pulmonary pathomechanisms. AM and blood monocytes (BM) were exposed to chrysotile B, soot FR 101, and Printex 90 (P 90). We evaluated the reactive oxygen intermediate (ROI) release of AM and BM after particle exposure. ROI release was measured by chemiluminescence. Thirty-minute exposure caused a significant (up to 2.5-fold) increase in ROI release of AM (100 micrograms/10(6) cells) compared with control experiments (p0.01). Identical exposure conditions for BM resulted in a similar reaction pattern (maximum 2.2-fold increase in ROI release; p0.05). After a 90-min particle exposu…

Interleukin-2 receptor gene expression by bronchoalveolar lavage lymphocytes in pulmonary sarcoidosis.

1989

Current concepts of the immunopathogenesis of sarcoidosis favor a central role of activated, interleukin-2 (IL-2) producing helper T-cells at sites of inflammation. Normally, activated T-cells release IL-2 and express IL-2 receptors (IL-2R). IL-2R+ cells, however, are not uniformly found in patients with clinically active disease. To determine whether the lack of IL-2R+ cells is caused by a dysregulation of the IL-2R gene or by the mode of T-cell activation in pulmonary sarcoidosis, we quantified IL-2 and IL-2R m-RNA transcripts, IL-2 release, and IL-2R surface protein in peripheral blood lymphocytes of patients with sarcoidosis and normal control subjects before and after in vitro stimulat…

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways.

2010

Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect of aclidinium, a new long-acting muscarinic antagonist, on MUC5AC expression in human airway epithelial cells. MUC5AC mRNA (RT-PCR) and protein expression (ELISA and immunohistochemistry) were studied in human bronchial tissue and differentiated human airway epithelial cells activated with carbachol (100 μM) or cigarette smoke extract in the absence or presence of aclidinium. Carbachol increased MUC5AC mRNA and protein expression in human bronchus and cultured epithelial cells. Aclidinium inhibited the carbachol-induced MUC…

TLR4 Up-regulation and Reduced Foxp3 Expression in Mechanically Ventilated Smokers with Obstructive Chronic Bronchitis

2013

Background: Chronic bronchitis (CB) is a risk factor in chronic obstructive pulmonary disease (COPD) for accelerated lung function decline and increased mortality. The lung and systemic inflammatory and immunological profile of COPD patients with CB which acutely experience respiratory failure upon a disease exacerbation is unknown. Methods: In this study, we explored the expression of Foxp3 by western blot analysis, TLR4 by immunocytochemistry and the concentrations of IP-10 and IL-8 by ELISA in the mini-bronchoalveolar lavages (mini-BAL) and in the peripheral blood of patients with respiratory failure requiring intubation and mechanical ventilation. The recruited subjects were separated i…

Authors' response to: epithelial mesenchymal transition (EMT) in small airways of COPD patient.

2013

We understand the reservations highlighted by Sohal and Walters in their letter in response to our recent work published.1 In their letter, Sohal and Walters argue that E-cadherin and ZO-1 are absent in our immunohistochemistry analysis of small bronchi of smokers and COPD patients, and that if disappeared completely epithelium would fall apart.1 In our study, we detected downregulation of E-cadherin and ZO-1 as well as a change of intercellular and apical distribution to diffuse cytoplasmic redistribution (figure 3B; in our work published in Thorax on 7 January 2013),2 but not …