Search results for "relationship"

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands

2013

Abstract Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines. The lead compound was synthesized by means of a short and effective two-step synthesis using Pd-catalyzed direct arylation. The compound stabilizes several quadruplex DNA sequences including a human telomeric DNA and one from the promoter of the HSP90 gene, although the structure–activity relationships of the series are not obviously related to the quadruplex binding.

Theorising love in sociological thought: Classical contributions to a sociology of love

2017

This article sets out to explore the contributions of classical social thinkers to a sociological understanding of love. It builds on the premise that despite its major relevance and consequential importance in shaping both individual lives and the social world, until recently love was a heavily undertheorised topic in the sociological tradition. Moreover, the body of disparate sociological reflections that have been made on the social nature of love has been largely forgotten in the discipline’s intellectual legacy. The article then proceeds in unearthing the classics’ contributions to a sociology of love. It starts with Max Weber’s view that love promises to be a means of sensual salvati…

Face-to-Face with the Doctor Online: Phenomenological Analysis of Patient Experience of Teleconsultation.

2022

The global crisis of the COVID-19 pandemic has considerably accelerated the adoption of teleconsultation—a form of consultation between patient and health care professional that occurs via videoconferencing platforms. For this reason, it is important to investigate the way in which this form of interaction modifies the nature of the clinical encounter and the extent to which this modification impacts the healing process. For this purpose, I will refer to insights into the clinical encounter as a face-to-face encounter drawn from the phenomenology of medicine (R. Zaner, K. Toombs, E. Pellegrino). I will also take into account a criticism that has been expressed by various contemporary phenom…

A structural insight into the P1 S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

2016

Abstract N′-substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected selectivity of these inhibitors of M1 alanine aminopeptidases (APNs) versus M17 leucine aminopeptidase (LAP). The diaminophosphonic acids were obtained via aziridines in an improved synthetic procedure that was further expanded for the phosphinic pseudodipeptide system. The inhibitory activity, measured for three M1 and one M17 metalloaminopeptidases of different sources (bacterial, human and porcine), revealed several potent compounds (e.g., K i  = 65 nM of 1u for Hs APN). Two structures of an M1 representative (APN from Neisser…

Deep center luminescence versus surface preparation of ZnSe single crystals

2001

A close relationship between the photoluminescence emissions labeled Y and S, related to dislocations and extended structural defects, and the preparation of the surface state of ZnSe single crystals before PL (photoluminescence) measurements has been established. The samples were obtained by solid-phase recrystallization under different pressure conditions. An easy method for achieving good quality surfaces with a very significant reduction of such Y and S PL emissions is proposed.

Power saturation of ESR signal in ammonium tartrate exposed to 60Co gamma-ray photons, electrons and protons.

2006

Abstract Marrale, M., Brai, M., Triolo, A., Bartolotta, A. and D'Oca, M. C. Power Saturation of ESR Signal in Ammonium Tartrate Exposed to 60Co γ-Ray Photons, Electrons and Protons. Radiat. Res. 166, 802–809 (2006). In this paper we present an investigation of the electron spin resonance (ESR) line shape of ammonium tartrate (AT) dosimeters exposed to radiation with different linear energy transfer (LET). We exposed our dosimeters to γ-ray photons (60Co), 7 MeV and 14 MeV initial energy electrons, and 19.3 MeV initial energy protons. The differences in the power saturation behavior of ESR spectra of AT irradiated with photons, electrons and protons could be correlated to the effective LET o…

Sensitivity of alanine dosimeters with gadolinium exposed to 6 MV photons at clinical doses.

2011

In this study we analyzed the ESR signal of alanine dosimeters with gadolinium exposed to 6 MV linear accelerator photons. We observed that the addition of gadolinium brings about an improvement in the sensitivity to photons because of its high atomic number. The experimental data indicated that the addition of gadolinium increases the sensitivity of the alanine to 6 MV photons. This enhancement was better observed at high gadolinium concentrations for which the tissue equivalence is heavily reduced. However, information about the irradiation setup and of the radiation beam features allows one to correct for this difference. Monte Carlo simulations were carried out to obtain information on …

Effect of attitudes toward Physical Education on motives to sport practice outside school hours

2016

[Resumen] La literatura especializada destaca la relación entre la participación de los adolescentes en actividades físicas y diversos beneficios físicos y psicosociales. Sin embargo, la actividad física de los adolescentes está por debajo de lo necesario para disfrutar de una buena salud física y psicológica. Existe consenso en que la Educación Física puede ayudar a los adolescentes a implicarse en actividades físicas y promover estilos de vida saludables. Por ello, el objetivo de este trabajo ha sido analizar la relación entre las actitudes hacia la Educación Física y los motivos para la práctica deportiva fuera del horario escolar. Han participado 428 alumnos de Educación Secundaria y 1º…

Spurious Singularities in Quasipotential Amplitudes

1973

Modeling electron dynamics coupled to continuum states in finite volumes with absorbing boundaries

2015

arXiv:1409.1689v1