Search results for "replica"
showing 10 items of 576 documents
Spin glasses: Experimental facts, theoretical concepts, and open questions
1986
This review summarizes recent developments in the theory of spin glasses, as well as pertinent experimental data. The most characteristic properties of spin glass systems are described, and related phenomena in other glassy systems (dielectric and orientational glasses) are mentioned. The Edwards-Anderson model of spin glasses and its treatment within the replica method and mean-field theory are outlined, and concepts such as "frustration," "broken replica symmetry," "broken ergodicity," etc., are discussed. The dynamic approach to describing the spin glass transition is emphasized. Monte Carlo simulations of spin glasses and the insight gained by them are described. Other topics discussed …
Bridging the Gap Between Atomistic and Coarse-Grained Models of Polymers: Status and Perspectives
2000
Recent developments that increase the time and distance scales accessible in the simulations of specific polymers are reviewed. Several different techniques are similar in that they replace a model expressed in fully atomistic detail with a coarse-grained model of the same polymer, atomistic → coarse-grained (and beyond!), thereby increasing the time and distance scales accessible within the expenditure of reasonable computational resources. The bridge represented by the right-pointing arrow can be constructed via different procedures, which are reviewed here. The review also considers the status of methods which reverse this arrow, atomistic ← coarse-grained. This “reverse-mapping” recover…
To make innovations such as replication mainstream, publish them in mainstream journals.
2019
AbstractIt was a pleasure to read Zwaan et al.'s wise and balanced target article. Here, I use it as a shining example for bolstering the argument that to make innovations such as replication mainstream, it seems advisable to move the debates from social media to respected “mainstream” psychology journals. Only then will mainstream psychologists be reached and, we hope, convinced.
Entry of Human Parechovirus 1
2001
ABSTRACT Human parechovirus 1 (HPEV-1) is a prototype member of parechoviruses, a recently established picornavirus genus. Although there is preliminary evidence that HPEV-1 recognizes α V integrins as cellular receptors, our understanding of early events during HPEV-1 infection is still very limited. The aim of this study was to clarify the entry mechanisms of HPEV-1, including the attachment of the virus onto the host cell surface and subsequent internalization. In blocking experiments with monoclonal antibodies against different receptor candidates, antibodies against α V and β 3 integrin subunits, in particular in combination, appeared to be the most efficient ones in preventing the HPE…
Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
2002
ABSTRACT The genome of the hepatitis C virus (HCV) is a plus-strand RNA molecule that carries a single long open reading frame. It is flanked at either end by highly conserved nontranslated regions (NTRs) that mediate crucial steps in the viral life cycle. The 3′ NTR of HCV has a tripartite structure composed of an about 40-nucleotide variable region, a poly(U/UC) tract that has a heterogeneous length, and a highly conserved 98-nucleotide 3′-terminal sequence designated the X tail or 3′X. Conflicting data as to the role the sequences in the 3′ NTR play in RNA replication have been reported. By using the HCV replicon system, which is based on the self-replication of subgenomic HCV RNAs in hu…
Cost of host radiation in an RNA virus.
2000
Abstract Although host radiation allows a parasite to expand its ecological niche, traits governing the infection of multiple host types can decrease fitness in the original or alternate host environments. Reasons for this reduction in fitness include slower replication due to added genetic material or modifications, fitness trade-offs across host environments, and weaker selection resulting from simultaneous adaptation to multiple habitats. We examined the consequences of host radiation using vesicular stomatitis virus (VSV) and mammalian host cells in tissue culture. Replicate populations of VSV were allowed to evolve for 100 generations on the original host (BHK cells), on either of two …
Pot la psicologia rescatar-se a si mateixa?. Incentius, biaix i replicabilitat
2018
En els últims anys la Psicologia està patint internament i externa una crisi important de credibilitat, a la qual tampoc han estat alienes altres ciències, com ara la Medicina o la Biologia. Diversos projectes de ciència de col·laboració suggereixen que una gran part dels resultats de la investigació són difícils de reproduir. Això ve acompanyat d’un conjunt de simulacions i anàlisis quantitatives que situen la quantitat de falsos positius per damunt del 50% del total de dades publicades en la literatura psicològica actual. En aquest breu treball realitzarem una anàlisi actualitzada de la situació i intentarem identificar les causes psicològiques que hi han contribuït. Entre aquestes destaq…
Mutagenesis scanning uncovers evolutionary constraints on tobacco etch Potyvirus membrane-associated 6K2 protein
2019
RNA virus high mutation rate is a double-edged sword. At the one side, most mutations jeopardize proteins functions; at the other side, mutations are needed to fuel adaptation. The relevant question then is the ratio between beneficial and deleterious mutations. To evaluate this ratio, we created a mutant library of the 6K2 gene of tobacco etch potyvirus that contains every possible single-nucleotide substitution. 6K2 protein anchors the virus replication complex to the network of endoplasmic reticulum membranes. The library was inoculated into the natural host Nicotiana tabacum, allowing competition among all these mutants and selection of those that are potentially viable. We identified 1…
Investigating Measures of Achievement Motivation(s)
2010
After a long debate there is now growing agreement that implicit and explicit achievement motivation can be seen as distinct constructs. One of their major differences lies in their predictive validity, which supposedly differs depending on the setting. Empirical evidence exists to the effect that different explicit measures based on different theoretical concepts build one construct. For implicit measures, however, such evidence is lacking. Thus, scores on three implicit and three explicit achievement motivation measures, an intelligence test, and a Big 5 questionnaire were obtained (N = 150) as well as two criteria. The explicit achievement motivation measures were classified as being ba…
DNA damage-induced cell death by apoptosis
2006
Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis. During the last ten years, specific DNA lesions that trigger apoptosis have been identified. These include O6-methylguanine, base N-alkylations, bulky DNA adducts, DNA cross-links and DNA double-strand breaks (DSBs). Repair of these lesions are important in preventing apoptosis. An exception is O6-methylguanine-thymine lesions, which require mismatch repair for triggering apoptosis. Apoptosis induced by many chemical genotoxins is the consequence of blockage of DNA replication, which leads to collapse of replication forks and DSB formation. These DSBs are thought to be crucial downstream apoptosis-tr…