Search results for "report"

showing 10 items of 2364 documents

IP 3 signalling regulates exogenous RNA i in C aenorhabditis elegans

2015

RNA interference (RNAi) is a widespread and widely exploited phenomenon. Here, we show that changing inositol 1,4,5-trisphosphate (IP3) signalling alters RNAi sensitivity in Caenorhabditis elegans. Reducing IP3 signalling enhances sensitivity to RNAi in a broad range of genes and tissues. Conversely up-regulating IP3 signalling decreases sensitivity. Tissue-specific rescue experiments suggest IP3 functions in the intestine. We also exploit IP3 signalling mutants to further enhance the sensitivity of RNAi hypersensitive strains. These results demonstrate that conserved cell signalling pathways can modify RNAi responses, implying that RNAi responses may be influenced by an animal's physiology…

inorganic chemicalscalcium signallingCell signalingMutantInositol 145-TrisphosphateBiologyModels BiologicalBiochemistryRNA interferenceRNA interferenceImage Processing Computer-AssistedGeneticsAnimalsIntestinal MucosaCaenorhabditis elegansMolecular BiologyCaenorhabditis elegansRNA Double-StrandedCalcium signalingenhanced RNAiScientific Reportsfungiinositol 145‐trisphosphateRNAbiology.organism_classificationC. elegansCell biologySignallingMicroscopy FluorescenceSignal transductionSignal TransductionEMBO reports
researchProduct

Crystal structure of hydrocortisone 17-butyrate

2014

In the title compound, C25H36O6, the two central cyclohexane rings exhibit a chair conformation. The terminal cyclohexene and cyclopentane rings are in half-chair and envelope conformations (with the C atom bearing the methyl substituent as the flap), respectively. The methyl group of the butyrate chain is disordered over two orientations, with a refined occupancy ratio of 0.742 (6):0.258 (6). Intramolecular O—H...O and C—H...O hydrogen bonds are observed. In the crystal, molecules are linked by O—H...O hydrogen bonds into chains running parallel to theaaxis.

inorganic chemicalscrystal structureCrystallographyHydrogen bondCyclohexane conformationeducationGeneral ChemistryButyrateCrystal structureCondensed Matter PhysicsBioinformaticsData ReportshumanitiesCrystalchemistry.chemical_compoundCrystallographychemistryQD901-999Atomhydrogen bondshydro­cortisone derivativehydrocortisone derivativeGeneral Materials Sciencepharmacological activityMethyl groupActa Crystallographica Section E
researchProduct

Reporting Intellectual Capital in Health Care organizations: Specifics, lessons learned, and future research perspectives

2011

This article analyzes the concept of intellectual capital (IC) in the health sector sphere by studying thecase of a major nonprofi t research organization in this sector, which has for some time been publishingIC reports. In the last few years, health care organizations have been the object of great attention in theimplementation and transfer of managerial models and tools; however, there is still a lack of attentionpaid to the strategic management of IC as a fundamental resource for supporting and enhancing performanceimprovement dynamics. The main aim of this article is to examine the IC reporting model usedby the Center of Molecular Medicine (CMM), a Swedish health organization which is …

intellectual capital (IC)case studyhealth sectorIC report
researchProduct

The application of intellectual capital reports in local authorities: analysis and empirical evidence

2011

This paper aims to investigate intellectual capital management in a public organisation as the Chambers of Commerce; in particular, whether and to what extent intellectual capital contributes to overall accountability and what role intellectual capital plays as a management tool. In order to answer these questions, the paper examines a case study, the Chamber of Commerce of Verbania Cusio Ossola that, at present, is one of the few in Italy, which prepares an intellectual capital report, by dedicating to it a special section in its social budget, where IC is reported. The paper also describes the intellectual capital report used in the Chamber of Commerce, the information supplied and the ro…

intellectual capital reportsInformation Systems and Managementbusiness.industryIndividual capitalStrategy and ManagementEconomic capitallocal authoritiesAccountingContext (language use)Intellectual capitalIntellectual capital managementFinancial capitalManagement of Technology and InnovationAccountabilityINTELLECTUAL CAPITAL REPORTEconomicsMarketingEmpirical evidencebusiness
researchProduct

La resistenza di interfaccia calcestruzzo poroso-terreni a grana fina per il consolidamento di pendii mediante trincee drenanti profonde

2022

Le trincee drenanti profonde rappresentano uno dei metodi più efficaci per la mitigazione del rischio da frana, in pendii con falda idrica. Esse sono realizzate mediante pannelli o pali secanti. Il riempimento è costituito di calcestruzzo poroso o materiale granulare. Se le trincee sono adeguatamente “innestate” nel terreno stabile e il materiale di riempimento ha sufficiente resistenza e rigidezza come il calcestruzzo poroso, si ha ulteriore in-cremento di resistenza a taglio per effetto shear keys, oltre a quello derivante dalla riduzione delle pressioni in-terstiziali. L’incremento di resistenza è dovuto sia alla resistenza all’interfaccia calcestruzzo–terreni sia a quella intrinseca del…

interface shear strengthPervious concreteSettore ICAR/07 - Geotecnicashear keys effect. Pervious concrete for deep trench drains used to stabilise slopes must simultaneously satisfy many requirements namely adequate hydraulic conductiv-ity adequate shear strength a few days after pour-ing capacity to act as a protective filter for soils in which the drain is installed good resistance to clog-ging and adequate residual hydraulic conductivity. The pervious concrete with appropriated mix-design can effectively satisfy all the abovementioned requirements. If the trenches depth is such that they intersect the sliding surface and if the trenches are adequate-ly "socket" in the layers of stable soil there is a fur-ther increase in shear strength due to the shear keys effect. This latter is in addition to the increase in shear strength resulting from the reduction of inter-stitial pressures that remains the principal scope of the draining trenches. Obviously the increase of shear strength due to the shear keys effect occurs if the trenches are filled with material that have enough strength and stiffness such as the porous concrete. In this case the beneficial effects of the draining trenches on stability are also due to the resistance at the concrete interface of the trench - soils and to the intrinsic resistance of the concrete at the area of the trench intersected by the sliding surface taken into consideration.The increase in resistance due to the shear keys effect can be very significant in relation to the thickness and interspace of the trenches. Results reported in the paper demonstrated that the interface fine grained soil-pervious concrete is higher than the residual shear strength of the soil.
researchProduct

Evolución de la información integrada en el mundo: análisis de sus primeras etapas de formulación

2017

La Información Integrada (IR), ha sido planteada como la concreción de toda la información de las organizaciones en un único documento, el cual debe ser preparado desde una perspectiva de sostenibilidad, y cuyo objetivo debe orientarse a informar acerca de la creación de valor por parte de las organizaciones (Eccles & Krzus, 2010). El objetivo de la IR es cubrir las crecientes demandas de transparencia e inclusión, por parte de todos los stakeholders de las organizaciones. Bajo el concepto de IR, se propone que los contenidos antes desplegados en distintos informes corporativos, ahora, no sólo se presenten juntos, sino que además sean pensados y producidos de manera integrada (Jensen & Berg…

international integrated reporting council (iirc)reportingdebido procesoinformación integradacomment letterslobbyingconectividadinternational integrated reporting frameworkexpert knowledgeniveles de divulgación de información integradainformación no financieraprograma piloto del IIRCcontabilidad
researchProduct

Alcohol Abuse Mediates the Association between Baseline T/C Ratio and Anger Expression in Intimate Partner Violence Perpetrators.

2015

The imbalance between testosterone (T) and cortisol (C) levels has been proposed as a possible marker of risk for intimate partner violence (IPV). Moreover, it could be related to a high probability of adopting risky behaviors such as alcohol abuse which, in turn, promotes the onset of IPV. This study tested the potential mediating effect of alcohol consumption on the relationship between baseline T/C ratio and anger expression in IPV perpetrators and non-violent controls. Alcohol consumption was higher in the former than controls. A high baseline T/C ratio was only associated with high anger expression in IPV perpetrators, and this association was mediated by high alcohol consumption. Thus…

intimate partner violencelcsh:BF1-990educationAlcohol abusePoison controlAlcoholDevelopmentSuicide preventionbehavioral disciplines and activitiesBehavioral Neurosciencechemistry.chemical_compoundInjury preventionmental disordersGeneticsmedicinetestosterone/cortisol ratioGeneral PsychologyEcology Evolution Behavior and SystematicsRecidivismalcoholanger expressionBrief ReportHuman factors and ergonomicssocial sciencesmedicine.diseaselcsh:PsychologychemistryDomestic violencePsychologySocial psychologyClinical psychologyBehavioral sciences (Basel, Switzerland)
researchProduct

Inwentaryzacja w aspekcie koncepcji rzetelnego i jasnego obrazu

2017

Cel – Zaprezentowanie inwentaryzacji jako podstawowego instrumentu weryfikacji zasobów majątku i kapitałów w celu prezentacji rzetelnego i jasnego obrazu sytuacji majątkowej i finansowej jednostki. Metodologia badania – Analiza literatury przedmiotu i przepisów prawnych (krajowych i międzynarodowych). Wynik – Wykazano, iż inwentaryzacja stanowi podstawowe narzędzie weryfikacji składników aktywów i pasywów przed ich ujęciem w sprawozdaniu finansowym. Sprzyja realizacji koncepcji rzetelnego i wiernego obrazu (true and fair view) w rachunkowości. Oryginalność/wartość – Wskazanie na przydatność inwentaryzacji w realizacji koncepcji wiernego i rzetelnego obrazu (true and fair view) na każdym eta…

inwentaryzacjainventoryfinancial reportingconcept of true and fair viewrachunkowośćkoncepcja rzetelnego i jasnego obrazuaccountingsprawozdanie finansoweZeszyty Naukowe Uniwersytet Szczeciński. Finanse, Rynki Finansowe, Ubezpieczenia
researchProduct

Validity of long-term and short-term recall of occupational sitting time in Finnish and Chinese office workers

2020

Background As sedentary behavior is a global health issue, there is a need for methods of self-reported sitting assessment. The accuracy and reliability of these methods should also be tested in various populations and different cultural contexts. This study examined the validity of long-term and short-term recall of occupational sitting time in Finnish and Chinese subgroups. Methods Two cohort groups of office-based workers (58.6% female, age range 22–67 years) participated: a Finnish group (FIN, n = 34) and a Chinese group (CHI, n = 36). Long-term (past 3-month sitting) and short-term (daily sitting assessed on 5 consecutive days) single-item measures were used to assess self-reported occ…

istuminensitting timemittauslaitteetquestionnairemittausvaliditeettiaccelerometrytoimistotyödaily recallistumatyöself-reporttoimistotyöntekijät
researchProduct

Varhaisnuorten emootiot suoriutumistilanteissa : taitotasoltaan erilaisten kuudesluokkalaisten perustunteiden tunnistaminen objektiivisesti ja subjek…

2017

Tässä tutkimuksessa on tarkasteltu varhaisnuorten tunteiden tunnistamista suoriutumistilanteissa. Subjektiivisesti ja objektiivisesti mitattujen tunteiden vastaavuuksia tarkasteltiin ottaen huomioon tehtävien vaikeustaso ja esittämisjärjestys, oppilaan kognitiivinen kykytaso, ylivilkkauden pulmat sekä tunteiden huippuhetket ja aallonpohjat. Tutkimus on toteutettu osana syksyllä 2013 käynnistynyttä TIKAPUU – Alakoulusta yläkouluun – tutkimushanketta, johon osallistuu 55 koululuokkaa kahdesta Keski-Suomen kunnasta. Tutkimuksen aineisto (n = 154) koostuu yksilötutkimuksiin osallistuneista nuorista, joiden kasvonilmeitä mitattiin FaceReader-ohjelman avulla heidän tehdessään yleisen päättelyn te…

itsearviointimittaaminenself-identification of emotionsfacial expressionsearly youthvarhaisnuoretomien tunteiden tunnistaminenself-reportsuoriutuminenpsykofysiologiatunteetachievement emotionsFaceReader-ohjelmailmeet
researchProduct