Search results for "respiratory syncytial virus"

showing 10 items of 36 documents

The incidence of influenza-associated hospitalizations in children in Germany

2002

Since new vaccines and anti-viral drugs for influenza have become available, collation of actual and country-specific epidemiological data is essential. Since respiratory syncytial virus (RSV) is a well known paediatric airway pathogen and some epidemiological data exist already, a comparison between influenza and RSV seems warranted. From July 1996 to June 2001 the naso-pharyngeal aspirates (NPA) of children from birth to 16 years of age, admitted to one of the two paediatric hospitals in Kiel, Germany, were investigated by a nine-valent multiplex reverse transcriptase PCR assay. NPA were investigated in 60·8% of 3469 children admitted with an acute respiratory tract infection. Community-a…

DNA BacterialMalemedicine.medical_specialtyPediatricsAdolescentHeart DiseasesEpidemiologyPopulationOrthomyxoviridaeRespiratory Syncytial Virus InfectionsRisk FactorsGermanyNasopharynxInfluenza HumanEpidemiologymedicineHumansChildeducationAcute respiratory tract infectionAsthmaeducation.field_of_studybiologyReverse Transcriptase Polymerase Chain Reactionbusiness.industryIncidenceIncidence (epidemiology)Infant NewbornInfantvirus diseasesmedicine.diseasebiology.organism_classificationAsthmaHospitalizationVaccinationInfectious DiseasesChild PreschoolFemaleViral diseasebusinessResearch ArticleEpidemiology and Infection
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Evaluation of a multiplex reverse transcriptase PCR ELISA for the detection of nine respiratory tract pathogens.

2003

A multiplex reverse transcription (RT) polymerase chain reaction combined with a microwell hybridization assay (m-RT-PCR-ELISA) was previously developed to detect nine different microorganisms: enterovirus (EV), influenza virus type A (IVA) and type B (IVB), respiratory syncytial virus (RSV), parainfluenzavirus type 1 (PIV1) and type 3 (PIV3), adenovirus (AV), Mycoplasma pneumoniae (Mpn), Chlamydia pneumoniae (Cpn) in a single test. These organisms do not usually colonize the respiratory tract of humans, but, if present, it may be assumed they are involved in respiratory disease.The m-RT-PCR-ELISA was tested on (i) culture supernatants of unknown contents, (ii) by determining the analytical…

Enzyme-Linked Immunosorbent AssayBiologymedicine.disease_causeSensitivity and SpecificityRespirovirusMicrobiologyAdenoviridaeVirologyMultiplex polymerase chain reactionmedicineHumansMultiplexRespiratory Tract InfectionsEnterovirusObserver VariationRespiratory tract infectionsReverse Transcriptase Polymerase Chain ReactionReproducibility of ResultsVirologyReverse transcriptaseRespiratory Syncytial VirusesReverse transcription polymerase chain reactionInfluenza B virusInfectious Diseasesmedicine.anatomical_structureRespiratory syncytial virus (RSV)Influenza A virusDNA ViralEnterovirusRespiratory tractJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology
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A population-based study relevant to seasonal variations in causes of death in children undergoing surgery for congenital cardiac malformations

2007

AbstractAimsOur objectives were, first, to study seasonal distribution of perioperative deaths within 30 days after surgery, and late death, in children undergoing surgery for congenitally malformed hearts, and second, to study the causes of late death.MethodsWe analysed a retrospective cohort of 1,753 children with congenital cardiac malformations born and undergoing surgery in the period from 1990 through 2002 with a special focus on the causes of late death. The data was obtained from the registry of congenital cardiac malformations at Rikshospitalet, Oslo, and the Norwegian Medical Birth Registry. The mean follow-up from birth was 8.1 years, with a range from zero to 15.2 years.ResultsD…

Heart Defects CongenitalMalePediatricsmedicine.medical_specialtyTime FactorsAdolescentrespiratory syncytial virussudden deathSudden deathCohort StudiesPostoperative Complicationsrespiratory infectionCause of DeathVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760medicineHumansChildDown's syndromeRetrospective StudiesVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771Norwaybusiness.industryInfant NewbornInfantRespiratory infectionGeneral MedicinemortalityPeer reviewSurvival RatePopulation based studyChild PreschoolPediatrics Perinatology and Child HealthFemaleSeasonsCardiology and Cardiovascular MedicineCongenital cardiac malformationsbusinessCardiology in the Young
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SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Identification of bronchiolitis profiles in Italian children through the application of latent class analysis

2020

AbstractBackgroundBronchiolitis is the primary infection of the lower respiratory tract in children under 2 years of age. Although it is generally considered a single nosological entity, recent studies suggested remarkable clinical heterogeneity. To date, no studies have identified classes of children with bronchiolitis within the Italian population. This study aimed to identify discrete profiles of Italian children hospitalized with bronchiolitis using a clustering approach and to compare findings with those obtained in international cohorts.MethodsThis was a retrospective single-centre study conducted on children aged ≤2 years hospitalised with bronchiolitis (n = 401) at the Department of…

MalePediatricsmedicine.medical_specialtyBreastfeedingRespiratory syncytial virusLatent class analysi03 medical and health sciencesSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineLatent class analysis030225 pediatricsmedicineHumans030212 general & internal medicineBronchiolitiChildrenRetrospective StudiesRespiratory distressEpidemic seasonbusiness.industryResearchlcsh:RJ1-570InfantApnealcsh:PediatricsGeneral Medicinemedicine.diseaseLatent class modelItalyBronchiolitisEtiologyBronchiolitisGeneral pediatricsFemalemedicine.symptombusinessChild HospitalizedItalian Journal of Pediatrics
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Paediatric intensive care admissions for respiratory syncytial virus bronchiolitis in France: results of a retrospective survey and evaluation of the…

2012

SUMMARYThe purpose of this study was to describe the characteristics of patients with bronchiolitis admitted to a paediatric intensive care unit (PICU), and to evaluate a national registry of hospitalizations (Programme de Médicalisation des Systèmes d'Information; PMSI) as a potential source of epidemiological data. Of the 49 French PICUs invited to take part in a retrospective survey of children aged <2 years who were hospitalized during the 2005–2006 epidemic season, 24 agreed to participate. Overall, 467 children were enrolled: 75% were aged <2 months, 76% had positive respiratory syncytial virus (RSV) tests, 34·9% required non-invasive ventilation, 36·6% were mechanically ventila…

MalePediatricsmedicine.medical_specialtyDatabases FactualEpidemiologymedicine.medical_treatment[ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/PediatricsRespiratory Syncytial Virus InfectionsIntensive Care Units Pediatric03 medical and health sciencesDatabases0302 clinical medicine030225 pediatricsEpidemiologymedicineBronchiolitis ViralHumans030212 general & internal medicineViralFactualRetrospective StudiesMechanical ventilationPediatric[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatricsbusiness.industryMortality rateRespirationRespiratory diseaseInfant NewbornInfantReproducibility of ResultsRetrospective cohort studymedicine.diseaseNewbornRespiration Artificial3. Good healthRespiratory Syncytial VirusesHospitalizationIntensive Care UnitsInfectious DiseasesBronchopulmonary dysplasiaBronchiolitisArtificialBreathingBronchiolitisFemaleFrancebusiness
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Nosocomial infection: A risk factor for a complicated course in children with respiratory syncytial virus infection – Results from a prospective mult…

2008

BACKGROUND: Nosocomially acquired respiratory syncytial virus infections (RSV-NI) may cause serious problems in hospitalized paediatric patients. Hitherto, prospectively collected representative data on RSV-NI from multicenter studies in Germany are limited. METHODS: The DMS RSV Ped database was designed for the prospective multicenter documentation and analysis of clinically relevant aspects of the management of inpatients with RSV-infection. The study covered six consecutive seasons (1999-2005); the surveillance took place in 14 paediatric hospitals in Germany. RESULTS: Of the 1568 prospectively documented RSV-infections, 6% (n=90) were NI and 94% (n=1478) were community acquired (CA). A …

MalePediatricsmedicine.medical_specialtyDatabases FactualHeart diseasemedicine.medical_treatmentRespiratory Syncytial Virus InfectionsSeverity of Illness IndexRisk FactorsGermanyNasopharynxSeverity of illnessmedicineHumansProspective StudiesRisk factorProspective cohort studyMechanical ventilationCross Infectionbusiness.industryRespiratory diseaseInfant NewbornPublic Health Environmental and Occupational HealthInfantHospitals Pediatricmedicine.diseaseRespiratory Syncytial VirusesCommunity-Acquired InfectionsPopulation SurveillanceRegression AnalysisFemaleViral diseaseComplicationbusinessInfant PrematureInternational Journal of Hygiene and Environmental Health
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Respiratory syncytial virus infection in a Sicilian pediatric population: Risk factors, epidemiology, and severity

2008

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTIs) in young children worldwide. This study evaluated the epidemiological and clinical patterns of RSV infection in infants hospitalized for LRTIs in Sicily. Over a 7-month period (October 1, 2005 to April 30, 2006), all children 6 months old, with a gestational age (GA) of >36 weeks, with a birth weight of >2.50 g, with previous hospitalizations due to LRTI, with smokers in the household, and with a history of breast-feeding (p < 0.05 for each). RSV infection was associated with a higher likelihood to be admitted to neonatal intensive care units and to longer hospitalization…

MalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtySettore MED/17 - Malattie InfettiveBirth weightRespiratory Syncytial Virus InfectionsTobacco smokeVirusSettore MED/38 - Pediatria Generale E SpecialisticaRisk FactorsIntensive careEpidemiologymedicineHumansBreast-feeding Hospitalization Infants Risk factors RSV infection Severity Trend seasonalImmunology and AllergyRespiratory systemSicilyRespiratory tract infectionsbusiness.industryInfant NewbornInfantGestational ageGeneral MedicineLogistic ModelsRespiratory Syncytial Virus HumanFemalebusinessAllergy and Asthma Proceedings
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Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association bet…

2002

This study was designed to collect data on the prevalence of respiratory syncytial virus (RSV) infection in Italy in infants hospitalized for lower respiratory tract infections, and to evaluate which of the recognized risk factors might be associated with disease severity. Thirty-two centers throughout Italy participated in the study. Over a 6-month period (November 1,1999 to April 30, 2000), we evaluated all children2 years of age hospitalized for lower respiratory tract infections. All subjects were tested for RSV within 24 hr of hospitalization by using an immuno-enzymatic diagnostic test (Abbott Testpack, RSV). Logistic regression was used to identify the factors that might be associate…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyBirth weightGestational AgeRespiratory Syncytial Virus InfectionsSeverity of Illness IndexRisk FactorsLower respiratory tract infectionInternal medicinePrevalencemedicineHumansRisk factorRespiratory Tract InfectionsRespiratory tract infectionsbusiness.industryRespiratory diseasePneumovirusmedicine.diseasePneumoniaItalyBronchiolitisAcute DiseasePediatrics Perinatology and Child HealthImmunologyFemaleTobacco Smoke PollutionBirth OrderbusinessPediatric Pulmonology
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Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis—A Prospective Cohort Study

2016

Objective The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. Methods In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, and picornavirus. Stools were examined for adenovirus, rotavirus, norovirus, and enterovirus.…

MalevirusesBacteremiamedicine.disease_causeLate Onset DisordersAdenovirus Infections HumanCohort StudiesFeces0302 clinical medicineRotavirusGermanyNasopharynxBlood culture030212 general & internal medicineProspective StudiesCoronavirusCaliciviridae InfectionsParamyxoviridae InfectionsNeonatal sepsismedicine.diagnostic_testReverse Transcriptase Polymerase Chain ReactionObstetrics and Gynecologyvirus diseasesVirus DiseasesOriginal ArticleFemaleNeonatal SepsisCoronavirus InfectionsEnzyme-Linked Immunosorbent AssayvirusRespiratory Syncytial Virus InfectionsRotavirus InfectionsSepsis03 medical and health sciences030225 pediatricsIntensive Care Units NeonatalInfluenza HumanmedicineEnterovirus InfectionsHumanslate-onset bacterial sepsisPicornaviridae Infectionsbusiness.industryInfant Newbornmedicine.diseaseVirologyneonatal intensive care unitinfectionBlood CultureBacteremiaPediatrics Perinatology and Child HealthImmunologyNorovirusEnterovirusbusinessMultiplex Polymerase Chain ReactionAmerican Journal of Perinatology
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