Search results for "response"

Acute Cardiovascular Responses after a Single Bout of Blood Flow Restriction Training.

2018

Different types of exercise might produce reductions in blood pressure (BP). One physiological mechanism that could explain the lowering adaptation effect on BP after an exercise program is an improved in baroreflex control of muscle sympathetic nerve activity. Consequently, exploring the different methods of training and their post-exercise hypotension (PEH) becomes of interest for healthcare providers. Recently, it has been suggested that blood flow restriction training (BFR) can generate PEH. The aim of this study was to determine the acute response on cardiovascular variables after low intensity resistance training with BFR in normotensive subjects. Twenty-four male (24.38±3.88 years) p…

The many lives of Hsp10: From Early Pregnancy Factor to Potential Antitumoral Agent. New Proteomic Data and a Review of the Literature Focusing on It…

2008

Does Bacillus thuringiensis Affect the Stress and Immune Responses of Rhynchophorus ferrugineus Larvae, Females, and Males in the Same Way?

2022

Simple Summary Rhynchophorus ferrugineus is a destructive quarantine pest of palm trees, now widely distributed. Although broad-spectrum insecticides are often used to protect palm against R. ferrugineus, there is increasing concern about their effects on the environment and human health, especially where palm trees are located in urban areas. As an environmentally friendly entomopathogen, Bacillus thuringiensis (Bt) has been widely used to prevent other pest infestations. Although Bt products are the most sold bio-insecticides, there are still many interesting features to be investigated in the relationship of Bt and its hosts. We investigated the effect of Bt on larvae, females, and males…

Imūnā atbildes reakcija uz vakcināciju pret vīrushepatītu B hemodialīzes pacientiem

2018

Pamatojums: Hemodialīzes (HD) pacientiem ir paaugstināts ar asinīm pārnesamām infekciju risks, piemēram, vīrushepatīta B infekcija (HBV). Pacientiem ar terminālu nieru mazspēju bieži ir imūnsistēmas nomākums, kas rezultējās ar nepietiekamu imūnās atbildes reakciju pret HBV vakcināciju. Adekvāta imunoloģiska atbilde it tad, ja anti-HBs-antivielu titrs >10 mSV/ml. Lai gan atbildes reakcija vispārējā populācijā ir aptuveni 95%, HD pacientiem tā ir robežās no 50-80%. Mērķis: noteikt HBV infekcijas izplatību, identificēt imūno atbildes reakciju HD pacientiem uz HBV vakcināciju un izvērtēt tās ietekmējošus klīniskus un laboratoriskus faktorus. Materiāli un metodes: Tika analizēta HBV izplatība HD…

Modeling cost-effectiveness and health gains of a “universal” versus “prioritized” hepatitis C virus treatment policy in a real-life cohort

2017

We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus–infected patients: policy 1, “universal,” treat all patients, regardless of fibrosis stage; policy 2, treat only “prioritized” patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virus–infected patients in care). Specifically, 8,125 patients naive to DAA treatment, without clinical, sociodemographic, or insurance restrictions, were us…

A Novel Approach to Identify Candidate Prognostic Factors for Hepatitis C Treatment Response Integrating Clinical and Viral Genetic Data

2015

The combined therapy of pegylated interferon (IFN) plus ribavirin (RBV) has been for a long time the standard treatment for patients infected with hepatitis C virus (HCV). In the case of genotype 1, only 38%–48% of patients have a positive response to the combined treatment. In previous studies, viral genetic information has been occasionally included as a predictor. Here, we consider viral genetic variation in addition to 11 clinical and 19 viral populations and evolutionary parameters to identify candidate baseline prognostic factors that could be involved in the treatment outcome. We obtained potential prognostic models for HCV subtypes la and lb in combination as well as separately. We …

Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms

2010

Background— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target. Methods and Results— We compared the effect of CETP single-nucleotide polymorphisms …

Hippocampal event-related potentials to tone-CS during classical conditioning of the rabbit nictitating membrane response

2004

Acceptance and commitment therapy for insomnia as a group intervention : predictors of treatment response

2014

JYVÄSKYLÄN YLIOPISTO Psykologian laitos NAAMANKA, ELINA & SUUTARI, VILLE: Ryhmämuotoinen hyväksymis- ja omistautumisterapia unettomuudesta kärsiville - hoitotulosta ennustavat tekijät Pro gradu-tutkielma, 33 s., 3 liittes. Ohjaajat: Jukka Kaartinen, Raimo Lappalainen Psykologia Toukokuu 2014 Tutkimuksessa tarkasteltiin unettomuudesta kärsiville suunnatun ryhmämuotoisen hyväksymis- ja omistautumisterapian (HOT) onnistuneeseen hoitotulokseen vaikuttavia tekijöitä. Tarkastelun kohteena olivat tutkittavien demografiset muuttujat, psykologinen ja fyysinen hyvinvointi, unettomuuden haittaavuus, HOT:n prosessit sekä persoonallisuustekijät. Näiden muuttujien ennustavuutta hoitotulokseen tarkastelti…

A systematic review of the literature on the human genetic variations in response to vaccination

2012

BACKGROUND: Vaccinomics is a term that refers to the investigation of heterogeneity of host genetic markers at the individual or population level that may result in variations of humoral, cell-mediated, and/or innate immune responses to vaccines. Studying genetic heterogeneity of human response to vaccines is supposed to both afford a better understanding of the way vaccine works, and help in developing future vaccines that are protective. With this premise in mind, we performed a systematic review of the literature on the studies concerning the association between human genetic variations in response to vaccination. METHODS: A detailed literature search on the case-control and cohort studi…