Search results for "rhinitis."

showing 10 items of 194 documents

Real-life assessment of chronic rhinosinusitis patients using mobile technology: the mySinusitisCoach project by EUFOREA

2020

Abstract Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient‐reported outcomes by mobile technology offers the possibility to better understand real‐life burden of CRS. Methods This study reports on the cross‐sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major sy…

Aplicacions mòbilsSYMPTOMSSinusititsvisual analogue scale0302 clinical medicineQuality of lifeMedicine and Health SciencesImmunology and AllergyNasal polyps030223 otorhinolaryngologyRhinitisnasal polypreal‐world evidenceASSOCIATION3. Good healthPREVALENCEALLERGIC RHINITISpatient-reported outcome measureCohortOriginal Articlepatient‐reported outcome measureENDOSCOPIC SINUS SURGERYmedicine.medical_specialtyVisual analogue scaleImmunologyMobile health technology03 medical and health sciencesNasal PolypsInternal medicinemedicineotorhinolaryngologic diseasesHumansNASALSinusitisreal-world evidenceDisease burdenMobile health technology; nasal polyp; patient-reported outcome measure; real-world evidence; visual analogue scaleTelecommunication in medicineAsthmabusiness.industryRhinitis Sinusitis and Upper Airway DiseaseFunctional endoscopic sinus surgerymedicine.diseasePrecision medicineSEVERITYCross-Sectional Studies030228 respiratory system3121 General medicine internal medicine and other clinical medicineChronic DiseaseMobile appsQuality of LifeASTHMAHuman medicineORIGINAL ARTICLESVISUAL ANALOG SCALEbusinessTelecomunicació en medicina
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Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach

2013

Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORγ(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mild-moderate asthma. The effect of Budesonide and Formoterol was tested "in vitro" on IL-17A, RORγ(t) and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of …

BudesonideMalePulmonologyIL 13 and AsthmaGene ExpressionAnti-asthmatic AgentBiochemistryPediatricsimmune system diseasesFormoterol FumarateMolecular Cell BiologyAnti-Asthmatic AgentsBudesonideChildCells CulturedMultidisciplinaryImmune System ProteinsQInterleukin-17RFOXP3Forkhead Transcription FactorsNuclear Receptor Subfamily 1 Group F Member 3EthanolaminesMedicineFemaleInterleukin 17medicine.symptommedicine.drugResearch ArticleRhinitis Allergic PerennialAdolescentScienceImmunologyPediatric PulmonologyInflammationAdministration InhalationmedicineHumansAdrenergic beta-2 Receptor AgonistsBiologyAsthmaInflammationbusiness.industryInterleukin-8SputumImmunityProteinsImmunologic Subspecialtiesmedicine.diseaseNasal Lavage FluidAsthmarespiratory tract diseasesCase-Control StudiesImmunologySputumTh17 CellsClinical ImmunologyFormoterolbusinessPulmonary Immunology
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Human dendritic cells transfected with allergen-DNA stimulate specific immunoglobulin G4 but not specific immunoglobulin E production of autologous B…

2007

Atopic/allergic diseases are characterized by T helper 2 (Th2)-dominated immune responses resulting in immunoglobulin E (IgE) production. DNA-based immunotherapies have been shown to shift the immune response towards Th1 in animal models. In further studies we showed that human dendritic cells (DC) transfected with allergen-DNA are able to stimulate autologous CD4(+) T cells from atopic individuals to produce Th1 instead of Th2 cytokines and to activate interferon-gamma (IFN-gamma)-producing CD8(+) T cells. The aim of this study was to analyse whether DC transfected with allergen-DNA are also able to influence immunoglobulin production of B cells from atopic donors. For this purpose, human …

CD4-Positive T-LymphocytesHypersensitivity ImmediateAllergyImmunologyCD8-Positive T-Lymphocytesmedicine.disease_causeImmunoglobulin ELymphocyte ActivationTransfectionAllergenImmune systemmedicineImmunology and AllergyHumansCells CulturedCell ProliferationPlant ProteinsRhinitisB-LymphocytesCD40biologyTransfectionOriginal ArticlesDendritic CellsAllergensImmunoglobulin ETh1 Cellsmedicine.diseaseCoculture TechniquesImmunoglobulin GImmunologybiology.proteinCytokinesAntibodyCD8T-Lymphocytes Cytotoxic
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Assessment of the Control of Allergic Rhinitis and Asthma Test (CARAT) using MASK-air

2021

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Caratmedicine.medical_specialtybusiness.industryMEDLINESettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.diseaseRhinitis AllergicAsthmaTest (assessment)Internal medicineHumansImmunology and AllergyMedicinebusinessRhinitisAsthmaThe Journal of Allergy and Clinical Immunology: In Practice
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Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and/or asthma: a GA(2)LEN taskforce position paper

2010

The GA(2)LEN taskforce on Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) published in 2009 a position paper concerning PROS and HRQoL assessment in clinical trials on allergy. Because of the specificity of this topic in asthma and rhinitis, specific recommendations are needed. The aim of this position paper is to define PROs and their meaning in asthma and rhinitis research, explore the available tools to provide criteria for a proper choice, identify patient-related factor which could influence PROs assessment, define specific recommendations for assessment, analysis and results spreading, underline the unexplored areas and unmet needs. PROs assessment is gaini…

Clinical Trials as TopicRhinitis Allergic PerennialHealth Planning GuidelinesRhinitis Allergic SeasonalAsthmahumanitiesOutcome Assessment (Health Care)Treatment OutcomeResearch DesignRhinitis Allergic Perennial; Humans; Rhinitis Allergic Seasonal; Health Planning Guidelines; Treatment Outcome; Clinical Trials as Topic; Quality of Life; Asthma; Outcome Assessment (Health Care); Research DesignHealth Planning GuidelineOutcome Assessment Health CareQuality of LifeHumansRinite Alérgica SazonalAsmaRhinitiQualidade de VidaHuman
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Non-specific bronchial hyper-responsiveness in children with allergic rhinitis: relationship with the atopic status

2003

An increased prevalence of bronchial hyper-responsiveness (BHR) has been demonstrated in children from a general population, and in non-asthmatic adults with allergic rhinitis. Thus, also children with allergic rhinitis are expected to be at higher risk of BHR. We evaluated the prevalence of BHR in a sample of non-asthmatic children with allergic rhinitis by means of the methacholine (Mch) bronchial challenge, and by monitorizing the airway patency using the daily peak expiratory flow variability (PEFv). Fifty-one children (ranged 6-15 years of age) with allergic rhinitis, ascertained by skin prick test to inhalant allergens, underwent a 14-day peak expiratory flow monitoring, and a Mch bro…

Cross-Sectional StudieHypersensitivity ImmediateMaleRhinitis Allergic PerennialAdolescentRespiratory Function Tests; Peak Expiratory Flow Rate; Airway Resistance; Vital Capacity; Bronchial Provocation Tests; Humans; Predictive Value of Tests; Child; Forced Expiratory Volume; Child Welfare; Cross-Sectional Studies; Rhinitis Allergic Perennial; Immunoglobulin E; Hypersensitivity Immediate; Bronchial Hyperreactivity; Statistics as Topic; Adolescent; Male; Biological Markers; Female; PrevalenceAirway ResistanceVital CapacityStatistics as TopicChild WelfarePeak Expiratory Flow RatePredictive Value of TestImmunoglobulin EBronchial Provocation TestForced Expiratory VolumeBiological MarkerPrevalenceFemaleBronchial HyperreactivityChildRespiratory Function TestHuman
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Association of Blattella germanica sensitization with atopic diseases in pediatric allergic patients

2011

The extent to which the sensitization to the German cockroach Blattella germanica (BG) affects onset/presence of rhinoconjunctivitis (RC) in children is unknown.

Cross-Sectional StudieHypersensitivity ImmediateMaleRhinitis Allergic PerennialSkin TestAdolescentAnimalQuestionnaireRisk FactorInfantBlattellidaeAsthmaInterviews as TopicAnimals; Questionnaires; Conjunctivitis Allergic; Skin Tests; Humans; Asthma; Child; Italy; Child Preschool; Infant; Cross-Sectional Studies; Rhinitis Allergic Perennial; Risk Factors; Blattellidae; Hypersensitivity Immediate; Interviews as Topic; Adolescent; Male; Female; PrevalenceItalyChild PreschoolPrevalenceFemaleChildConjunctivitis AllergicHuman
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Proportional Venn diagram and determinants of allergic respiratory diseases in Italian adolescents

2011

Large variations in prevalence of atopy and allergic diseases are reported worldwide in children, but in epidemiological studies the use of skin prick tests (SPT) and spirometry along with questionnaires is not common in the Mediterranean Area. The present work was aimed at evaluating the prevalence of current asthma (CA), rhinoconjunctivitis (RC), and eczema (E), with atopy and respiratory function, and the role of risk factors for allergic respiratory diseases. A total of 2150 Italian schoolchildren were cross-sectionally investigated through respiratory questionnaire, SPT, and spirometry. A proportional Venn diagram quantified the distribution of CA, RC, and E, stratifying for allergic s…

Cross-Sectional StudieHypersensitivity ImmediateMaleSkin TestAdolescentQuestionnaireRisk FactorEczemaAsthmaItalySpirometryPrevalenceRespiratory Function Tests; Questionnaires; Conjunctivitis Allergic; Skin Tests; Humans; Asthma; Rhinitis; Child; Eczema; Italy; Cross-Sectional Studies; Spirometry; Risk Factors; Hypersensitivity Immediate; Adolescent; Female; Male; PrevalenceFemaleChildRhinitiRespiratory Function TestConjunctivitis AllergicHuman
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Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus monteluk…

2004

BACKGROUND: Corticosteroids are considered to be particularly effective in reducing nasal congestion and are therefore recommended as first-line treatment in allergic rhinitis patients with moderate to severe and/or persistent symptoms. OBJECTIVE: We compared the clinical efficacy of fluticasone propionate aqueous nasal spray (FPANS) 200 microg given once daily, administered in mono-therapy or combined therapy with a H1 receptor antagonist (cetirizine, CTZ) or with a leukotriene antagonist (montelukast, MSK), and the combined therapy of CTZ plus MSK in the treatment of patients affected by allergic rhinitis to Parietaria during natural pollen exposure. In addition, we examined the effect of…

CyclopropanesMaleAllergySettore MED/09 - Medicina Internamedicine.medical_treatmentseasonal allergic rhinitisAcetatesGastroenterologyImmunology and AllergyMedicineChildFluticasonepollen seasonRandomized placebo-controlled trialBlood Proteinsrespiratory systemEosinophil Granule ProteinsMiddle AgedCetirizineAnesthesiamontelukastHistamine H1 AntagonistsQuinolineseosinophil cationic proteinDrug Therapy CombinationFemaleeosinophilsmedicine.symptommedicine.drugAdultmedicine.medical_specialtyAdolescentImmunologyNasal congestionSulfidesPlaceboFluticasone propionateDrug Administration ScheduleRibonucleasesDouble-Blind MethodInternal medicineHumansRandomized placebo-controlled trial; fluticasone; cetirizine; montelukast; seasonal allergic rhinitisGlucocorticoidsMontelukastAdministration IntranasalAnalysis of Variancerhinorrheafluticasone propionatebusiness.industrynasal lavageRhinitis Allergic Seasonalmedicine.diseaseCetirizineAndrostadienesParietariaNasal sprayFluticasoneLeukotriene AntagonistsNasal administrationbusinessClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
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Knowledge of the literature is crucial for meta-analyses

2014

Desensitization ImmunologicManagement scienceImmunologyHumansRhinitis Allergic SeasonalImmunology and AllergyPsychologyJournal of Allergy and Clinical Immunology
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