Search results for "scaffold"

4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules

2020

Abstract The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review of literature revealed how such kind of fused heterocycles, coming from natural or synthetic source, are associated with a wide range of biological activities. This review is mainly directed towards the 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle in which all the possible combinations of nitrogen, sulfur and oxygen atoms are present.

Tetraethynylethene molecular scaffolding: Nonlinear optical, redox, and amphiphilic properties of donor functionalized polytriacetylene and expanded …

1997

Improving vascularization of engineered bone through the generation of pro-angiogenic effects in co-culture systems

2014

One of the major problems with bone tissue engineering is the development of a rapid vascularization after implantation to supply the growing osteoblast cells with the nutrients to grow and survive as well as to remove waste products. It has been demonstrated that capillary-like structures produced in vitro will anastomose rapidly after implantation and become functioning blood vessels. For this reason, in recent years many studies have examined a variety of human osteoblast and endothelial cell co-culture systems in order to distribute osteoblasts on all parts of the bone scaffold and at the same time provide conditions for the endothelial cells to migrate to form a network of capillary-li…

Tissue engineering: how to build a heart

2015

Decellularization and recellularization of hearts from newly dead donors is the latest fashion in cardiac tissue engineering. The first paper came out in 2008 in Nature Medicine (Ott et al., 2008), and news has been recently published in Nature again in July 2013 (Maher, 2013). Brendan Maher in this paper summarizes and comments on the latest important results on decellularization of a human heart and explains the steps that are necessary to build a heart from a decellularized organ. Two sources may be used to obtain a decellularized heart: human and pig heart. Another issue to resolve is the time of decellularization, since the detergents used may also destroy the architecture of the organ…

Preparation and characterization of a biologic scaffold from esophageal mucosa

2013

Biologic scaffolds composed of extracellular matrix (ECM) are commonly used to facilitate a constructive remodeling response in several types of tissue, including the esophagus. Surgical manipulation of the esophagus is often complicated by stricture, but preclinical and clinical studies have shown that the use of an ECM scaffold can mitigate stricture and promote a constructive outcome after resection of full circumference esophageal mucosa. Recognizing the potential benefits of ECM derived from homologous tissue (i.e., site-specific ECM), the objective of the present study was to prepare, characterize, and assess the in-vivo remodeling properties of ECM from porcine esophageal mucosa. The…

Scaffolding Effect of Vascular Distension on Peripheral Lung Mechanics

2013

Tissue engineered vascular grafts based on poly-lactic acid blends

2013

A great deal of research has been pursued in the last decade with the goal of developing blood vessel substitutes. Tissue engineering has emerged as a promising approach to address the shortcomings of current options. One of the major tasks in this research field is the possibility to tune the biodegradability of the implantable devices (scaffolds). After implantation, the scaffold has to be replaced by extra cellular matrix; with this respect, it is crucial that this replacement takes place with appropriate dynamics and a well-defined timescale. In this work tissue-engineered vascular graft were produced, utilizing several PLLA/PLA blends (100/0, 90/10, 75/25 wt/wt) in order to tune their …

Macroporous Scaffolds Based on Chitosan and Bioactive Molecules†

2007

Chitosan-based macroporous scaffolds for tissue engineering applications are developed by cryogelation in aqueous media. The cryogels obtained are modified using a new RGD-containing peptide developed in this laboratory. A RGD-containing peptide is chemically attached to the surface of the cryogels to improve cell adhesion to the 3D-structure chitosan-based scaffolds. The synthesis, physico-chemical, and biological evaluations of the system are described, and the optimization of the formulations is carried out by varying the reaction parameters. Fibroblasts and endothelial cells are used in cell cultures to determine cell behavior and the cytocompatibility of the macroporous cryogels. Cell …

Preparation and characterization of PLLA-HA scaffolds for bone tissue engineering

2013

In this work, the possibility to produce composite - Poly-L-lactic acid (PLLA) and Hydroxyapatite (HA) - porous scaffolds via Thermally Induced Phase Separation for bone tissue engineering applications was investigated. Several PLLA/HA ratios were tested (70/30, 50/50, 30/70 and 20/80 wt/wt) and the as-obtained scaffolds were characterized via Scanning Electron Microscopy (SEM), Wide Angle X-Ray Diffraction (WAXD) and compression test. The results showed that the presence of HA does not influence the phase separation process. Morphological analysis revealed an open structure with interconnected pores and HA embedded in the polymer matrix. This evidence was confirmed by WAXD analysis; where …

A COMPOSITE PLLA SCAFFOLD FOR REGENERATION OF COMPLEX TISSUES

2010

A composite biodegradable scaffold incorporating an integrated network of synthetic blood vessels was designed and prepared, in line with the requirements of a scaffold effectively supporting the regeneration of highly vascularized tissues. In other words, this composite scaffold should allow the regeneration of complex injured tissue (e.g. dermis) and, at the same time, favour the development of a vascular network on its inner, i.e. a 3D polymeric scaffolds embedding synthetic blood vessel-like structures for nutrient supply and metabolite removal. PLLA assures a high degree of biocompatibility and a low level of inflammation response upon implantation, while the embedded tubular vessel-li…