Search results for "score"

showing 10 items of 852 documents

Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and…

2020

Objective Two previous individual participant data meta-analyses (IPDMAs) found that different diagnostic interviews classify different proportions of people as having major depression overall or by symptom levels. We compared the odds of major depression classification across diagnostic interviews among studies that administered the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D). Methods Data accrued for an IPDMA on HADS-D diagnostic accuracy were analysed. We fit binomial generalized linear mixed models to compare odds of major depression classification for the Structured Clinical Interview for DSM (SCID), Composite International Diagnostic Interview (CIDI), and…

MaleDepressive disordersSCHEDULESACCURACYSocio-culturaleHospital Anxiety and Depression ScaleOdds03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingIndividual participant data meta-analysisMedicineHumansMajor depression030212 general & internal medicineVALIDITYDepression (differential diagnoses)Mini-international neuropsychiatric interviewProbabilityPsychiatric Status Rating ScalesDepressive Disorder MajorDepressive disorders Diagnostic interviews Hospital Anxiety and Depression Scale Individual participant data meta-analysis Major depressionbusiness.industryIndividual participant dataOdds ratioCIDIAn individual participant data meta-analysis of 73 primary studies.- Journal of psychosomatic research cilt.129 ss.109892 2020 [Wu Y. Levis B. Sun Y. Krishnan A. He C. Riehm K. Rice D. Azar M. Yan X. Neupane D. et al. -Probability of major depression diagnostic classification based on the SCID CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores]3. Good healthPsychiatry and Mental healthClinical PsychologyHospital Anxiety and Depression ScaleMeta-analysisDiagnostic interviews/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalebusiness030217 neurology & neurosurgeryClinical psychology
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Medical pre-hospital management reduces mortality in severe blunt trauma: a prospective epidemiological study

2011

International audience; INTRODUCTION: Severe blunt trauma is a leading cause of premature death and handicap. However, the benefit for the patient of pre-hospital management by emergency physicians remains controversial because it may delay admission to hospital. This study aimed to compare the impact of medical pre-hospital management performed by SMUR (Service Mobile d'Urgences et de Réanimation) with non-medical pre-hospital management provided by fire brigades (non-SMUR) on 30-day mortality. METHODS: The FIRST (French Intensive care Recorded in Severe Trauma) study is a multicenter cohort study on consecutive patients with severe blunt trauma requiring admission to university hospital i…

MaleEmergency Medical ServicesTime FactorsMESH : AgedMESH : Prospective StudiesPoison controlCritical Care and Intensive Care Medicine0302 clinical medicineInjury Severity ScorePatient AdmissionEmergency medical services[ SHS.INFO ] Humanities and Social Sciences/Library and information sciences030212 general & internal medicineHospital MortalityProspective StudiesProspective cohort studyMESH: Treatment OutcomeMESH: AgedMESH: Middle AgedMortality rate[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologieMESH : Patient AdmissionMESH : AdultMiddle Aged3. Good healthMESH : Wounds and InjuriesIntensive Care UnitsTreatment OutcomeBlunt traumaMESH: Young AdultBlunt traumaMESH: Emergency Medical ServicesInjury Severity ScoreMESH : Injury Severity ScoreFranceMESH: FirefightersMESH : Intensive Care UnitsCohort studyMESH : Time FactorsAdultmedicine.medical_specialtyAdolescentMESH : Male[SHS.INFO]Humanities and Social Sciences/Library and information sciencesMESH: Injury Severity ScoreMESH : Young AdultMESH : Treatment Outcome[SHS.INFO] Humanities and Social Sciences/Library and information sciencesMESH : Hospital Mortality03 medical and health sciencesYoung AdultIntensive careMESH : AdolescentmedicineHumansMESH : Emergency Medical ServicesMESH : Middle AgedMESH: Hospital MortalityIntensive care medicineMESH : FranceAgedMESH: AdolescentMESH: Humansbusiness.industryMESH: Patient AdmissionResearchMESH : HumansMESH: Time Factors030208 emergency & critical care medicineMESH: AdultMESH: MaleMESH: Prospective StudiesMESH: France[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieMESH: Wounds and InjuriesFirefightersEmergency medicineWounds and InjuriesMESH: Intensive Care Units[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieMESH : FirefightersbusinessCritical Care
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Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study

2022

Publisher Copyright: © 2022 The Authors Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially …

MaleEmploymentperinnölliset tauditskitsofrenia515 Psychologytyöllistyminen3121 Internal medicinebehavioral disciplines and activities3124 Neurology and psychiatryperinnöllinen alttiusEducationCohort Studiestyömarkkina-asemaPsychiatry and Mental healthkoulutustasoPolygenic risk scoreRisk FactorsEarningsSocial income transfersmental disordersSchizophreniaEducational StatusHumansBiological PsychiatryJournal of Psychiatric Research
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Pasireotide treatment reduces cardiometabolic risk in Cushing’s disease patients: an Italian, multicenter study

2018

Purpose: Patients with Cushing’s disease (CD) experience metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index (VAI) has been proposed as a marker of visceral adipose tissue dysfunction (ATD) and of the related cardiometabolic risk. We aimed to evaluate the impact of 12-month pasireotide treatment on cardiometabolic risk in CD patients. Methods: This is a multicentre, prospective, and observational study. Sixteen CD patients, referred to the Endocrine Units of the University Hospitals of Messina, Napoli, Padova, and Palermo (Italy), successfully treated with pasireotide for 12 month have been enrolled. In all patients, we assessed anthro…

MaleEndocrinology Diabetes and MetabolismCardiometabolic risk Cushing’s disease hypercortisolism pasireotide visceral adiposity indexLongitudinal StudieDisease030204 cardiovascular system & hematologySettore MED/13 - Endocrinologiachemistry.chemical_compound0302 clinical medicineEndocrinologyRisk FactorsMedicineLongitudinal StudiesProspective StudiesAdiposityFramingham Risk ScoreCushing’s diseaseCushing’s diseaseMiddle AgedPasireotideDiabetes and MetabolismHeart DiseaseItalyAtherosclerosiObesity AbdominalFemaleSomatostatinHumanAdultmedicine.medical_specialtyWaistHeart DiseasesHypercortisolism030209 endocrinology & metabolismIntra-Abdominal Fat03 medical and health sciencesMetabolic DiseasesInternal medicineDiabetes mellitusCardiometabolic risk; Cushing’s disease; Hypercortisolism; Pasireotide; Visceral adiposity index; Endocrinology Diabetes and Metabolism; EndocrinologyHumansPituitary ACTH Hypersecretionbusiness.industryRisk FactorCushing's diseaseAnthropometryAtherosclerosismedicine.diseasePasireotideCardiometabolic riskMetabolic DiseaseVisceral adiposity indexProspective StudiechemistryObservational studybusiness
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Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases

2021

Supplemental digital content is available in the text.

MaleEpidemiologyPhysical fitnessType 2 diabetesDiseaseLogistic regressionTYPE 2 DIABETESOrthopedics and Sports Medicine315 Sport and fitness sciencesPREDICTORSChildkohorttitutkimusFinlandAged 80 and oversairastavuusHERITABILITYGenetic PleiotropyriskitekijätMiddle AgedCardiovascular DiseasesChild PreschoolCohortComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFemaleSMOKINGgeneettiset tekijätfyysinen aktiivisuusAdultGenetic Markerskuolleisuusmedicine.medical_specialtyAdolescentGenotypePhysical Therapy Sports Therapy and RehabilitationEXERCISEpitkittäistutkimusLower riskRisk AssessmentYoung AdultMetabolic DiseasesInternal medicineClinical Decision RulesBENEFITSmedicineHumansAgedbusiness.industryRISK SCORESCardiometabolic Risk FactorsInfantOdds ratiomedicine.diseaseGENEBODY-MASS INDEXLogistic ModelsCase-Control StudiesLinear Modelssydän- ja verisuonitauditbusinessBody mass indexGenome-Wide Association Study
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Extended right colectomy, left colectomy, or segmental left colectomy for splenic flexure carcinomas: a European multicenter propensity score matchin…

2020

Background: The surgical resection of the splenic flexure carcinoma (SFC) is challenging and the optimal surgical procedure for SFCs remains a matter of debate. The present study aimed to compare in a multicenter European sample of patients the short- and long-term outcomes of extended right (ERC) vs. left (LC) vs. segmental left colectomy (SLC) for SFCs. Methods: This retrospective multicenter study analyzed the surgical and oncological outcomes of SFC patients undergoing elective curative intent surgery between 2000 and 2018. Descriptive and exploratory analyses were first conducted on the whole sample. Outcomes of the different procedures (ERC vs. LC vs. SLC) were then compared using pro…

MaleExtended right colectomy0302 clinical medicinePostoperative ComplicationsColectomyComputingMilieux_MISCELLANEOUSSplenic fexure carcinomaAged 80 and overddc:617Middle Aged3. Good healthTreatment OutcomeElective Surgical Procedures030220 oncology & carcinogenesisColonic Neoplasms030211 gastroenterology & hepatologyExtended right colectomyFemaleLeft colectomyColon TransverseAdultmedicine.medical_specialtyOperative TimeSegmental left colectomyDisease-Free SurvivalResection03 medical and health sciencesPostoperative complicationsExtended right colectomy; Left colectomy; Postoperative complications; Propensity score matching; Segmental left colectomy; Splenic flexure carcinomaInternal medicinePropensity score matchingmedicineCarcinomaHumansPropensity ScoreAgedRetrospective StudiesSplenic flexurebusiness.industrySplenic flexure carcinomaLeft colectomyCarcinoma[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyHepatologyLength of Staymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologySurgeryPostoperative complicationPropensity score matchingSurgeryLaparoscopyLymph NodesbusinessAbdominal surgery
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Genetic linkage of autosomal dominant progressive supranuclear palsy to 1q31.1

2005

Progressive supranuclear palsy (PSP) is a disorder of unknown pathogenesis. Familial clusters of PSP have been reported related to mutations of protein tau. We report the linkage of a large Spanish family with typical autosomal dominant PSP to a new locus in chromosome 1. Four members of this family had typical PSP, confirmed by neuropathology in one case. At least five ancestors had similar disease. Other members of the family have incomplete phenotypes. The power of the linkage analysis was increased by detecting presymptomatic individuals with 18F-fluoro-dopa and 18F-deoxyglucose positron emission tomography. We screened the human genome with 340 polymorphic markers and we enriched the a…

MaleGenetic LinkageTau proteinLocus (genetics)NeuropathologyProgressive supranuclear palsyGenetic linkagemedicineHumansAgedBrain ChemistryGeneticsbiologyPutamenChromosomeDNAMiddle Agedmedicine.diseaseeye diseasesDihydroxyphenylalaninePedigreeChromosome 17 (human)GlucosePhenotypeNeurologyChromosomes Human Pair 1Genetic markerPositron-Emission Tomographybiology.proteinFemaleSupranuclear Palsy ProgressiveNeurology (clinical)Caudate NucleusLod ScoreRadiopharmaceuticalsAnnals of Neurology
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A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

2008

As part of the International Multi-centre ADHD Gene (IMAGE) project we have completed an affected sibling pair study of 142 narrowly defined DSM-IV combined type ADHD proband-sibling pairs. We found suggestive linkage on chromosomes 9 and 16 with non-parametric multipoint peak LOD scores of 2.13 and 3.1 respectively. There have been several previous ADHD linkage scans. The UCLA study (Fisher et al. 2002; Ogdie et al. 2004; Ogdie et al. 2003), the Dutch study (Bakker et al. 2003), the German study (Hebebrand et al. 2006) and the MGH Study (Faraone et al., submitted) applied the affected sib pair (ASP) strategy; the Columbian study used extended pedigrees ascertained from a population isolate…

MaleGenetics and epigenetic pathways of disease [NCMLS 6]GENOMEWIDE SCANMedizin2804 Cellular and Molecular NeuroscienceCHILDRENComorbidityNeuroinformatics [DCN 3]Severity of Illness IndexDevelopmental psychology2738 Psychiatry and Mental Health0302 clinical medicinePerception and Action [DCN 1]HETEROGENEITYIsraelChildGeneticsObserver Variation0303 health sciencesATTENTION-DEFICIT/HYPERACTIVITY DISORDERPSYCHIATRIC-DISORDERSDOPAMINE TRANSPORTER GENEASSOCIATION10058 Department of Child and Adolescent PsychiatryEuropePsychiatry and Mental healthFemalePsychologyChromosomes Human Pair 9linkageFunctional Neurogenomics [DCN 2]GenotypeDEFICIT HYPERACTIVITY DISORDER610 Medicine & healthPolymorphism Single NucleotideMental health [NCEBP 9]Genetic determinismWhite PeopleGenomic disorders and inherited multi-system disorders [IGMD 3]03 medical and health sciencesCellular and Molecular NeuroscienceCognitive neurosciences [UMCN 3.2]Genetic linkage1312 Molecular BiologymedicineSNPAttention deficit hyperactivity disorderHumansADHDSiblingMolecular Biology030304 developmental biologyLinkage (software)SiblingsChromosomemedicine.diseaseSib pairsUnited Statesaffected sib pairsGenetic defects of metabolism [UMCN 5.1]Attention Deficit Disorder with HyperactivityCONDUCT DISORDERLod ScoreDISEQUILIBRIUM030217 neurology & neurosurgeryChromosomes Human Pair 16
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Acromesomelic dysplasia Maroteaux type maps to human chromosome 9.

1998

SummaryAcromesomelic dysplasias are skeletal disorders that disproportionately affect the middle and distal segments of the appendicular skeleton. We report genetic mapping studies in four families with acromesomelic dysplasia Maroteaux type (AMDM), an autosomal recessive osteochondrodysplasia. A peak LOD score of 5.1 at recombination fraction 0 was obtained with fully informative markers on human chromosome 9. In three of the four families, the affected offspring are products of consanguineous marriages; if it is assumed that these affected offspring are homozygous by descent for the region containing the AMDM locus, a 6.9-cM AMDM candidate interval can be defined by markers D9S1853 and D9…

MaleGenotypeGenetic LinkageLocus (genetics)Chromosome 9ConsanguinityBiologyOsteochondrodysplasiasGenetic determinismBone and BonesConsanguinityGene mappingmedicineGeneticsHumansGenetics(clinical)OsteochondrodysplasiaGenetics (clinical)GeneticsChromosome 9Chromosome Mappingmedicine.diseaseOsteochondrodysplasiaPedigreeRadiographyMappingAcromesomelic dysplasia Maroteaux typeFemaleChromosome 20Lod ScoreChromosomes Human Pair 9Acromesomelic dysplasiaResearch ArticleMicrosatellite Repeats
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Genetic endowments, parental resources and adult health: Evidence from the Young Finns Study

2017

This paper uses longitudinal survey data linked to administrative registers to examine socioeconomic gradients in health, particularly whether the effects of genetic endowments interact with the socioeconomic resources of the parental household. We find that genetic risk scores contribute to adult health measured by biomarkers. This result is consistent with the findings from genome-wide association studies. Socioeconomic gradients in health differ based on biomarker and resource measures. Family education is negatively related to obesity and the waist-hip ratio, and family income is negatively related to low-density lipoprotein cholesterol and triglyceride levels. Parental resources do not…

MaleGerontologyHealth (social science)Social Determinants of HealthHealth StatusbiomarkkeritGenome-wide association studyBody Mass Index0302 clinical medicineSurveys and QuestionnairesLongitudinal Studies030212 general & internal medicine050207 economicsFinlandgenetic risk scores05 social sciencesta3142riskitekijätIncomeFemaleSportsAdultparental resourcesgenetiikkaResource (biology)Kansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational healthympäristötekijätFamily income03 medical and health sciencesHistory and Philosophy of Science0502 economics and businessFood QualitymedicineHumansSocioeconomic statussosioekonomiset tekijätTriglyceridesAdult healthGenetic associationta511business.industryta1184Cholesterol HDLadult healthbiomarkersCholesterol LDLmedicine.diseaseObesityperhetaustaSocioeconomic Factorsmarkkeritgenome-wide association studiesSurvey data collectionterveyserotbusinessGenome-Wide Association StudyDemographySocial Science & Medicine
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